waixenicin-a and Adenocarcinoma

waixenicin-a has been researched along with Adenocarcinoma* in 2 studies

Other Studies

2 other study(ies) available for waixenicin-a and Adenocarcinoma

Article	Year
Inhibition of TRPM7 suppresses cell proliferation of colon adenocarcinoma in vitro and induces hypomagnesemia in vivo without affecting azoxymethane-induced early colon cancer in mice. Cell communication and signaling : CCS, 2017, 08-15, Volume: 15, Issue:1 Magnesium (Mg. To establish a possible link between systemic magnesium (Mg. We find that TRPM7 drives colon cancer cell proliferation in human HT-29 and expresses in normal primary mouse colon epithelia. This is linked to TRPM7's dominant role as Mg. Early stage colon cancer proceeds independent of systemic Mg Topics: Acetates; Adenocarcinoma; Animals; Azoxymethane; Calcium; Cell Proliferation; Cells, Cultured; Colonic Neoplasms; Diterpenes; HT29 Cells; Humans; Intestinal Absorption; Magnesium Deficiency; Male; Mice; Mice, Inbred C57BL; TRPM Cation Channels	2017
The role of waixenicin A as transient receptor potential melastatin 7 blocker. Basic & clinical pharmacology & toxicology, 2013, Volume: 112, Issue:2 Transient receptor potential melastatin 7 (TRPM7) plays a role in a number of physiological and pharmacological functions in variety of cells. The aim of this study was to clarify the role for TRPM7 channels and the effect of waixenicin A on the pacemaking activity of interstitial cells of Cajal (ICCs) and on the cell viability of the human gastric and breast adenocarcinoma cell lines, AGS and MCF-7, respectively. Waixenicin A decreased the amplitude of pacemaker potentials in cultured ICC clusters and inhibited TRPM7 currents, but had no effect on Ca(2+) -activated Cl(-) conductance (ANO1). Furthermore, waixenicin A was found to inhibit the growth and survival of AGS and MCF-7 cells. These findings indicate that TRPM7 channel modulates intestinal motility and regulates the pathophysiology of human gastric and breast adenocarcinoma cells. These findings suggest that TRPM7 channel be considered a potential target for the treatment of gut motor disorders and gastric and breast cancer. Topics: Acetates; Adenocarcinoma; Animals; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Diterpenes; Female; Gastrointestinal Motility; Humans; Interstitial Cells of Cajal; Male; Membrane Potentials; Mice; Mice, Inbred BALB C; Protein Serine-Threonine Kinases; Stomach Neoplasms; TRPM Cation Channels	2013

Article

Year

Inhibition of TRPM7 suppresses cell proliferation of colon adenocarcinoma in vitro and induces hypomagnesemia in vivo without affecting azoxymethane-induced early colon cancer in mice.

Cell communication and signaling : CCS, 2017, 08-15, Volume: 15, Issue:1

Magnesium (Mg. To establish a possible link between systemic magnesium (Mg. We find that TRPM7 drives colon cancer cell proliferation in human HT-29 and expresses in normal primary mouse colon epithelia. This is linked to TRPM7's dominant role as Mg. Early stage colon cancer proceeds independent of systemic Mg

Topics: Acetates; Adenocarcinoma; Animals; Azoxymethane; Calcium; Cell Proliferation; Cells, Cultured; Colonic Neoplasms; Diterpenes; HT29 Cells; Humans; Intestinal Absorption; Magnesium Deficiency; Male; Mice; Mice, Inbred C57BL; TRPM Cation Channels

2017

The role of waixenicin A as transient receptor potential melastatin 7 blocker.

Basic & clinical pharmacology & toxicology, 2013, Volume: 112, Issue:2

Transient receptor potential melastatin 7 (TRPM7) plays a role in a number of physiological and pharmacological functions in variety of cells. The aim of this study was to clarify the role for TRPM7 channels and the effect of waixenicin A on the pacemaking activity of interstitial cells of Cajal (ICCs) and on the cell viability of the human gastric and breast adenocarcinoma cell lines, AGS and MCF-7, respectively. Waixenicin A decreased the amplitude of pacemaker potentials in cultured ICC clusters and inhibited TRPM7 currents, but had no effect on Ca(2+) -activated Cl(-) conductance (ANO1). Furthermore, waixenicin A was found to inhibit the growth and survival of AGS and MCF-7 cells. These findings indicate that TRPM7 channel modulates intestinal motility and regulates the pathophysiology of human gastric and breast adenocarcinoma cells. These findings suggest that TRPM7 channel be considered a potential target for the treatment of gut motor disorders and gastric and breast cancer.

Topics: Acetates; Adenocarcinoma; Animals; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Diterpenes; Female; Gastrointestinal Motility; Humans; Interstitial Cells of Cajal; Male; Membrane Potentials; Mice; Mice, Inbred BALB C; Protein Serine-Threonine Kinases; Stomach Neoplasms; TRPM Cation Channels

2013