w 7 has been researched along with Torsade de Pointes in 5 studies
W 7: RN given refers to parent cpd; structure; calmodulin antagonist
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the effects of W-7, a calmodulin inhibitor, on transmural dispersion of repolarization (TDR), early after depolarization (EAD) and torsade de pointes (TdP) induction after administration of d-sotalol in isolated rabbit heart." | 7.73 | [Calmodulin antagonist inhibits torsade de pointes induced by d-sotalol in an isolated rabbit heart model]. ( Bai, R; Li, Y; Liu, N; Pu, J; Wang, L; Zhang, CT, 2005) |
| "To evaluate the effects of W-7, a calmodulin inhibitor, on transmural dispersion of repolarization (TDR), early after depolarization (EAD) and torsade de pointes (TdP) induction after administration of d-sotalol in isolated rabbit heart." | 3.73 | [Calmodulin antagonist inhibits torsade de pointes induced by d-sotalol in an isolated rabbit heart model]. ( Bai, R; Li, Y; Liu, N; Pu, J; Wang, L; Zhang, CT, 2005) |
| "The ventricular arrhythmia torsade de pointes (TdP) occurs after QT interval prolongation and is associated with sudden cardiac death." | 1.30 | Systemic administration of calmodulin antagonist W-7 or protein kinase A inhibitor H-8 prevents torsade de pointes in rabbits. ( Anderson, ME; Mazur, A; Roden, DM, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kijtawornrat, A | 1 |
| Ziolo, MT | 1 |
| Nishijima, Y | 1 |
| Roche, BM | 1 |
| Hamlin, RL | 1 |
| Pu, J | 1 |
| Zhang, CT | 1 |
| Bai, R | 1 |
| Liu, N | 1 |
| Li, Y | 1 |
| Wang, L | 1 |
| Lu, HR | 1 |
| Vlaminckx, E | 1 |
| Van de Water, A | 1 |
| Gallacher, DJ | 1 |
| Mazur, A | 1 |
| Roden, DM | 2 |
| Anderson, ME | 2 |
| Gbadebo, TD | 1 |
| Trimble, RW | 1 |
| Khoo, MS | 1 |
| Temple, J | 1 |
5 other studies available for w 7 and Torsade de Pointes
| Article | Year |
|---|---|
Effects of sarcolemmal Ca(2+) entry, ryanodine function, and kinase inhibitors on a rabbit model of heart failure.
Topics: Animals; Anti-Arrhythmia Agents; Benzylamines; Disease Models, Animal; Heart Failure; Isoquinolines; | 2010 |
[Calmodulin antagonist inhibits torsade de pointes induced by d-sotalol in an isolated rabbit heart model].
Topics: Animals; Calmodulin; Enzyme Inhibitors; Female; In Vitro Techniques; Rabbits; Sotalol; Sulfonamides; | 2005 |
Calmodulin antagonist W-7 prevents sparfloxacin-induced early afterdepolarizations (EADs) in isolated rabbit purkinje fibers: importance of beat-to-beat instability of the repolarization.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Electrophysiologic Techniques, Cardiac; Enzym | 2006 |
Systemic administration of calmodulin antagonist W-7 or protein kinase A inhibitor H-8 prevents torsade de pointes in rabbits.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1999 |
Calmodulin inhibitor W-7 unmasks a novel electrocardiographic parameter that predicts initiation of torsade de pointes.
Topics: Animals; Arrhythmias, Cardiac; Calmodulin; Disease Models, Animal; Electrocardiography; Enzyme Inhib | 2002 |