w 7 has been researched along with Muscle Contraction in 44 studies
W 7: RN given refers to parent cpd; structure; calmodulin antagonist
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Effects of N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), chlorpromazine, prenylamine and N2-dansyl-L-arginine-4-t-butylpiperidine amide on vascular smooth muscle contraction were compared by using helically cut strips of rabbit aorta." | 3.66 | Effects of various calmodulin antagonists on contraction of rabbit aortic strips. ( Asano, M; Hidaka, H; Suzuki, Y, 1982) |
| "Isovitexin was devoid of activity on duodenums." | 1.34 | The spasmolytic effect of Aloysia citriodora, Palau (South American cedrón) is partially due to its vitexin but not isovitexin on rat duodenums. ( Conforti, P; Consolini, AE; Ragone, MI; Sella, M; Volonté, MG, 2007) |
| "1." | 1.28 | W-7, a calmodulin antagonist, and contracture of malignant hyperthermia susceptible skeletal muscle. ( Holland, M; Lee, JC; Williams, JH, 1992) |
| " The influence of bepridil on the dose-response curves of mesenteric arterial strips for CaCl2, norepinephrine and serotonin differed from the influence seen with nifedipine, another Ca++ blocker." | 1.27 | Effects on calmodulin of bepridil, an antianginal agent. ( Hidaka, H; Ishikawa, T; Itoh, H, 1984) |
| " This compound shifted the dose-response curve for CaCl2 to the right, in a competitive manner." | 1.27 | Modulation of calmodulin function and of Ca2+-induced smooth muscle contraction by the calmodulin antagonist, HT-74. ( Hidaka, H; Ishikawa, T; Ito, M; Itoh, H; Kawamatsu, Y; Saitoh, M; Shin, T; Sugihara, H; Tanaka, T; Umekawa, H, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (47.73) | 18.7374 |
| 1990's | 17 (38.64) | 18.2507 |
| 2000's | 4 (9.09) | 29.6817 |
| 2010's | 1 (2.27) | 24.3611 |
| 2020's | 1 (2.27) | 2.80 |
| Authors | Studies |
|---|---|
| Borovikov, YS | 1 |
| Andreeva, DD | 1 |
| Avrova, SV | 1 |
| Sirenko, VV | 1 |
| Simonyan, AO | 1 |
| Redwood, CS | 1 |
| Karpicheva, OE | 1 |
| Strittmatter, F | 1 |
| Gratzke, C | 1 |
| Weinhold, P | 1 |
| Steib, CJ | 1 |
| Hartmann, AC | 1 |
| Schlenker, B | 1 |
| Andersson, KE | 1 |
| Hedlund, P | 1 |
| Stief, CG | 1 |
| Hennenberg, M | 1 |
| An, SS | 1 |
| Laudadio, RE | 1 |
| Lai, J | 1 |
| Rogers, RA | 1 |
| Fredberg, JJ | 1 |
| Terada, S | 1 |
| Muraoka, I | 1 |
| Tabata, I | 1 |
| Adhikari, BB | 1 |
| Wang, K | 1 |
| Ragone, MI | 1 |
| Sella, M | 1 |
| Conforti, P | 1 |
| Volonté, MG | 1 |
| Consolini, AE | 1 |
| Itoh, H | 3 |
| Ishikawa, T | 4 |
| Hidaka, H | 12 |
| Tanaka, T | 5 |
| Kajita, T | 1 |
| Taniguchi, N | 1 |
| Mita, H | 1 |
| Mishima, T | 1 |
| Yui, Y | 1 |
| Shida, T | 1 |
| Sheaves, RM | 1 |
| Yamakado, T | 1 |
| Nishikawa, M | 1 |
| Azuma, H | 1 |
| Kreye, VA | 1 |
| Rüegg, JC | 1 |
| Hofmann, F | 1 |
| Asano, M | 3 |
| Suzuki, Y | 1 |
| Cantabrana, B | 1 |
| Perez Vallina, JR | 1 |
| Menéndez, L | 1 |
| Hidalgo, A | 1 |
| Houenou, LJ | 1 |
| Sahuqué, MV | 1 |
| Villageois, AP | 1 |
| Yu, P | 1 |
| Harnett, KM | 1 |
| Biancani, P | 3 |
| De Petris, G | 1 |
| Behar, J | 1 |
| Nakazawa, K | 1 |
| Higo, K | 1 |
| Abe, K | 1 |
| Tanaka, Y | 1 |
| Saito, H | 1 |
| Matsuki, N | 1 |
| Honda, K | 1 |
| Takano, Y | 1 |
| Kamiya, H | 1 |
| Etgen, GJ | 1 |
| Fryburg, DA | 1 |
| Gibbs, EM | 1 |
| Amobi, NI | 1 |
| Smith, IC | 1 |
| Gadano, AC | 1 |
| Sogni, P | 1 |
| Heller, J | 1 |
| Moreau, R | 1 |
| Bories, PN | 1 |
| Lebrec, D | 1 |
| Holland, M | 1 |
| Williams, JH | 1 |
| Lee, JC | 1 |
| Frampton, JE | 1 |
| Orchard, CH | 1 |
| Bitar, KN | 3 |
| Kaminski, MS | 1 |
| Hailat, N | 1 |
| Cease, KB | 1 |
| Strahler, JR | 1 |
| Matsui, T | 1 |
| Sugawa, M | 1 |
| Johshita, H | 1 |
| Takuwa, Y | 1 |
| Asano, T | 1 |
| Youn, JH | 1 |
| Gulve, EA | 1 |
| Holloszy, JO | 1 |
| Hillemeier, C | 2 |
| Balazovich, KJ | 1 |
| Marshall, JM | 1 |
| Tokumitsu, H | 1 |
| Nakajima, S | 1 |
| Kurokawa, K | 1 |
| Imamura, N | 1 |
| Ueda, M | 1 |
| Gibson, A | 1 |
| Shaw, CR | 1 |
| Wermelskirchen, D | 1 |
| Koch, P | 1 |
| Wilhelm, D | 1 |
| Nebel, U | 1 |
| Leidig, A | 1 |
| Wilffert, B | 1 |
| Peters, T | 1 |
| Ruzycky, AL | 1 |
| Morgan, KG | 1 |
| Ogawa, Y | 1 |
| Kurebayashi, N | 1 |
| Umekawa, H | 1 |
| Saitoh, M | 1 |
| Shin, T | 1 |
| Ito, M | 1 |
| Kawamatsu, Y | 1 |
| Sugihara, H | 1 |
| Inagaki, M | 1 |
| Mitani, Y | 1 |
| Moreland, S | 1 |
| Little, DK | 1 |
| Moreland, RS | 1 |
| LeGrue, SJ | 1 |
| Turner, R | 1 |
| Weisbrodt, N | 1 |
| Dedman, JR | 1 |
| Ashoori, F | 1 |
| Tomita, T | 1 |
2 reviews available for w 7 and Muscle Contraction
| Article | Year |
|---|---|
Calmodulin: a multifunctional protein for the control of cellular activity and homeostasis. A review of its physico-chemical properties and pharmacological manipulation.
Topics: Animals; Calcium-Transporting ATPases; Calmodulin-Binding Proteins; Carrier Proteins; Enzyme Activat | 1982 |
[Molecular pharmacology on intracellular calcium messenger system].
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actomyosin; Binding Sites; Calcium; Calcium Channel B | 1986 |
42 other studies available for w 7 and Muscle Contraction
| Article | Year |
|---|---|
Molecular Mechanisms of the Deregulation of Muscle Contraction Induced by the R90P Mutation in Tpm3.12 and the Weakening of This Effect by BDM and W7.
Topics: Actins; Animals; Calcium; Muscle Contraction; Muscle Fibers, Skeletal; Mutation; Myofibrils; Myosins | 2021 |
Thromboxane A2 induces contraction of human prostate smooth muscle by Rho kinase- and calmodulin-dependent mechanisms.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Aged; Amides; Calcium; Calmoduli | 2011 |
Stiffness changes in cultured airway smooth muscle cells.
Topics: Actin Cytoskeleton; Actins; Animals; Bronchoconstrictor Agents; Calmodulin; Cells, Cultured; Cytoske | 2002 |
Changes in [Ca2+]i induced by several glucose transport-enhancing stimuli in rat epitrochlearis muscle.
Topics: Aminacrine; Animals; Biological Transport; Caffeine; Calcium; Dantrolene; Fura-2; Glucose; Hypoxia; | 2003 |
Interplay of troponin- and Myosin-based pathways of calcium activation in skeletal and cardiac muscle: the use of W7 as an inhibitor of thin filament activation.
Topics: Animals; Calcium; Diacetyl; Dose-Response Relationship, Drug; Elasticity; Heart; Mice; Muscle Contra | 2004 |
The spasmolytic effect of Aloysia citriodora, Palau (South American cedrón) is partially due to its vitexin but not isovitexin on rat duodenums.
Topics: Acetylcholine; Animals; Apigenin; Calcium Chloride; Dose-Response Relationship, Drug; Duodenum; Enzy | 2007 |
Effects on calmodulin of bepridil, an antianginal agent.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Anti-Arrhythmia Agents; Bepridil; Calmodulin; Cattle; | 1984 |
Naphthalenesulfonamides as calmodulin antagonists.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Ca(2+) Mg(2+)-ATPase; Calcium-Transporting ATPases; Ca | 1983 |
Inhibition of slow-reacting substance release by calmodulin blocker.
Topics: Autacoids; Calcimycin; Calmodulin; Diltiazem; Humans; Leukocytes; Mites; Muscle Contraction; Muscle, | 1984 |
Pharmacological properties of platelet strips.
Topics: Adenosine Diphosphate; Alprostadil; Angiotensin II; Aorta; Blood Platelets; Humans; In Vitro Techniq | 1983 |
Effect of calcium-antagonist and calmodulin-antagonist drugs on calmodulin-dependent contractions of chemically skinned vascular smooth muscle from rabbit renal arteries.
Topics: Animals; Calcium Channel Blockers; Calcium-Binding Proteins; Calmodulin; Female; Male; Muscle Contra | 1983 |
Effects of various calmodulin antagonists on contraction of rabbit aortic strips.
Topics: Animals; Aorta, Thoracic; Calcium-Binding Proteins; Calmodulin; Chlorpromazine; Diamines; Female; In | 1982 |
Biopharmacological assessment of calmodulin function: utility of calmodulin antagonist naphthalenesulfonamide.
Topics: Animals; Calcium-Binding Proteins; Calmodulin; Chlorpromazine; Diamines; In Vitro Techniques; Muscle | 1981 |
Activity-structure relationship of calmodulin antagonists, Naphthalenesulfonamide derivatives.
Topics: Animals; Aorta, Thoracic; Binding, Competitive; Calcium-Binding Proteins; Calmodulin; Female; In Vit | 1981 |
Spasmolytic and calmodulin inhibitory effect of non-steroidal anti-inflammatory drugs in vitro.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Calmodulin; C | 1995 |
Calcium influxes and calmodulin modulate the expression and physicochemical properties of acetylcholinesterase molecular forms during development in vivo.
Topics: Acetylcholinesterase; Action Potentials; Animals; Calcimycin; Calcium; Calmodulin; Chick Embryo; Dec | 1993 |
Interaction between signal transduction pathways contributing to gallbladder tonic contraction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calmodulin; Cats; Diglycerides; Fem | 1993 |
Blockade by calmodulin inhibitors of Ca2+ channels in smooth muscle from rat vas deferens.
Topics: Animals; Barium; Calcium; Calcium Channel Blockers; Calmodulin; Imidazoles; In Vitro Techniques; Mal | 1993 |
Involvement of protein kinase C in muscarinic agonist-induced contractions of guinea pig ileal longitudinal muscle.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Carbachol; Diglycerides; Guinea Pig | 1996 |
Nitric oxide stimulates skeletal muscle glucose transport through a calcium/contraction- and phosphatidylinositol-3-kinase-independent pathway.
Topics: 3-O-Methylglucose; Androstadienes; Animals; Calcium; Dantrolene; Dibutyryl Cyclic GMP; Enzyme Inhibi | 1997 |
Caffeine- and noradrenaline-induced contractions of human vas deferens: contrasting effects of procaine, ryanodine and W-7.
Topics: Anesthetics, Local; Caffeine; Calcium; Calmodulin; Humans; In Vitro Techniques; Male; Muscle Contrac | 1998 |
Vascular nitric oxide production during the development of two experimental models of portal hypertension.
Topics: Animals; Aorta, Thoracic; Disease Models, Animal; Guanidines; Hypertension, Portal; In Vitro Techniq | 1999 |
W-7, a calmodulin antagonist, and contracture of malignant hyperthermia susceptible skeletal muscle.
Topics: Animals; Caffeine; Calcium; Calmodulin; Dantrolene; Drug Synergism; Halothane; Intercellular Signali | 1992 |
The effect of a calmodulin inhibitor on intracellular [Ca2+] and contraction in isolated rat ventricular myocytes.
Topics: Actin Cytoskeleton; Animals; Caffeine; Calcium; Calmodulin; Cells, Cultured; Heart; Hydrogen-Ion Con | 1992 |
Hsp27 is a mediator of sustained smooth muscle contraction in response to bombesin.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Anal Canal; Animals; Antibodies, Monoclonal; Bombesin | 1991 |
Activation of the protein kinase C-mediated contractile system in canine basilar artery undergoing chronic vasospasm.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Basilar Artery; Chronic Disease; Dinoprost; | 1991 |
Calcium stimulates glucose transport in skeletal muscle by a pathway independent of contraction.
Topics: 3-O-Methylglucose; Adenosine Triphosphate; Aminacrine; Animals; Biological Transport, Active; Caffei | 1991 |
Regulation of smooth muscle contraction in rabbit internal anal sphincter by protein kinase C and Ins(1,4,5)P3.
Topics: Anal Canal; Animals; Brain; Calcimycin; Cell Membrane Permeability; In Vitro Techniques; Inositol 1, | 1991 |
Intracellular pathways for contraction in gastroesophageal smooth muscle cells.
Topics: Acetylcholine; Animals; Benzimidazoles; Calmodulin; Cats; Esophagus; Female; Gastric Fundus; In Vitr | 1991 |
[Calmodulin dependent regulation of smooth muscle contraction].
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Azepines; Calcium; Calmodulin; Isoquinolines | 1990 |
Molecular pharmacology of calcium, calmodulin-dependent myosin phosphorylation in vascular smooth muscle.
Topics: Animals; Azepines; Calcium; Calmodulin; Cattle; In Vitro Techniques; Male; Muscle Contraction; Muscl | 1990 |
A study on the hypotensive mechanism of pinacidil: relationship between its vasodilating effect and intracellular Ca2+ levels.
Topics: Animals; Antihypertensive Agents; Calcium; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; | 1989 |
The effect of Ca deprivation and of Ca-blocking drugs on oxytocin-induced contractions of the male mouse anococcygeus.
Topics: Animals; Calcium; Calcium Channel Blockers; Calmodulin; Egtazic Acid; In Vitro Techniques; Male; Mic | 1989 |
Effect of calmodulin antagonists on contraction and 45Ca movements in rat aorta.
Topics: Animals; Aorta, Thoracic; Calcium; Calcium Radioisotopes; Calmodulin; Imidazoles; In Vitro Technique | 1989 |
Involvement of the protein kinase C system in calcium-force relationships in ferret aorta.
Topics: Animals; Aorta, Thoracic; Calcium; Ferrets; In Vitro Techniques; Isometric Contraction; Male; Muscle | 1989 |
Modulations by drugs of the relationship between calcium binding to troponin C and tension.
Topics: Animals; Caffeine; Calcium; Calmodulin; Chlorpromazine; In Vitro Techniques; Isometric Contraction; | 1989 |
Divergent pharmacological effects of three calmodulin antagonists, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), chlorpromazine and calmidazolium, on isometric tension development and myosin light chain phosphorylation in intact bovine trachea
Topics: Animals; Atropine; Calmodulin; Carbachol; Cattle; Chlorpromazine; Imidazoles; In Vitro Techniques; M | 1989 |
Modulation of calmodulin function and of Ca2+-induced smooth muscle contraction by the calmodulin antagonist, HT-74.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Anilino Naphthalenesulfonates; Animals; Benzothiazoles; | 1986 |
The binding of the calcium channel blocker, bepridil, to calmodulin.
Topics: Animals; Bepridil; Binding, Competitive; Calcium Channel Blockers; Calmodulin; Cattle; Chickens; Enz | 1986 |
Calmodulin antagonists inhibit latch bridges in detergent skinned swine carotid media.
Topics: Adenosine Triphosphate; Animals; Calcium; Calmodulin; Carotid Arteries; Cytidine Triphosphate; Deter | 1987 |
Does the binding of cyclosporine to calmodulin result in immunosuppression?
Topics: Animals; Calmodulin; Cyclosporine; Cyclosporins; Immune Tolerance; Lymphocyte Activation; Mice; Musc | 1986 |
Carbachol-induced contraction in the circular muscle of guinea-pig stomach in calcium-free solution.
Topics: Animals; Calcium; Calmodulin; Carbachol; Dose-Response Relationship, Drug; Female; Guinea Pigs; In V | 1986 |