w 7 has been researched along with Melanoma in 6 studies
W 7: RN given refers to parent cpd; structure; calmodulin antagonist
Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Tamoxifen (TAM) markedly increases the response rate of malignant melanoma to treatment with cisplatin (DDP), carmustine, and dacarbazine, and we have previously reported that there is a highly synergistic interaction between TAM and DDP with respect to the cytotoxic effect against the human melanoma cell line T-289 (E." | 7.68 | Tamoxifen modulation of cisplatin sensitivity in human malignant melanoma cells. ( Albright, KD; Christen, RD; Howell, SB; Jones, JA; McClay, EF, 1993) |
| "Tamoxifen (TAM) markedly increases the response rate of malignant melanoma to treatment with cisplatin (DDP), carmustine, and dacarbazine, and we have previously reported that there is a highly synergistic interaction between TAM and DDP with respect to the cytotoxic effect against the human melanoma cell line T-289 (E." | 3.68 | Tamoxifen modulation of cisplatin sensitivity in human malignant melanoma cells. ( Albright, KD; Christen, RD; Howell, SB; Jones, JA; McClay, EF, 1993) |
| "Two drugs known to inhibit the action of calmodulin, prochlorperazine offP) and N-(6-aminohexyl)-5-chloro-1-napthalene sulfonamide (W7), were investigated for their ability to control cell proliferation in murine B16 melanoma cells in culture." | 3.67 | Effects of extracellular calmodulin and calmodulin antagonists on B16 melanoma cell growth. ( Bleehen, SS; Mac Neil, S; Senior, HJ; Tomlinson, S; Walker, SW, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (83.33) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Walker, SW | 2 |
| Mac Neil, S | 2 |
| Senior, HJ | 2 |
| Bleehen, SS | 2 |
| Tomlinson, S | 2 |
| Ito, H | 1 |
| Hidaka, H | 1 |
| McClay, EF | 1 |
| Albright, KD | 1 |
| Jones, JA | 1 |
| Christen, RD | 1 |
| Howell, SB | 1 |
| Kitagawa, T | 1 |
| Amano, F | 1 |
| Akamatsu, Y | 1 |
| Lönn, U | 1 |
| Lönn, S | 1 |
6 other studies available for w 7 and Melanoma
| Article | Year |
|---|---|
Calmodulin activation of cyclic AMP phosphodiesterase in the B16 mouse melanoma.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Calmodulin; Cells, Cultured; Cyclic AMP; Enzyme Activa | 1984 |
Antitumor effect of calmodulin antagonist against MH-134 hepatoma, Ehrlich ascites carcinoma and B-16 melanocarcinoma in mice.
Topics: Animals; Calmodulin; Carcinoma, Ehrlich Tumor; Liver Neoplasms, Experimental; Melanoma; Mice; Neopla | 1983 |
Effects of extracellular calmodulin and calmodulin antagonists on B16 melanoma cell growth.
Topics: Animals; Calmodulin; Cell Line; Cells, Cultured; Culture Media; DNA, Neoplasm; Dose-Response Relatio | 1984 |
Tamoxifen modulation of cisplatin sensitivity in human malignant melanoma cells.
Topics: Antineoplastic Agents; Calmodulin; Cell Cycle; Cisplatin; Drug Resistance; Drug Synergism; Enzyme In | 1993 |
External ATP-induced passive permeability change and cell lysis of cultured transformed cells: action in serum-containing growth media.
Topics: Adenosine Triphosphate; Animals; Blood; Calcium; Calmodulin; Cell Membrane Permeability; Cell Surviv | 1988 |
W-7, a calmodulin inhibitor, potentiates dacarbazine cytotoxicity in human neoplastic cells.
Topics: Calmodulin; Cell Division; Cell Line; Cell Survival; Dacarbazine; DNA Repair; DNA Replication; DNA, | 1987 |