Page last updated: 2024-11-05

w 7 and Melanoma

w 7 has been researched along with Melanoma in 6 studies

W 7: RN given refers to parent cpd; structure; calmodulin antagonist

Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)

Research Excerpts

ExcerptRelevanceReference
"Tamoxifen (TAM) markedly increases the response rate of malignant melanoma to treatment with cisplatin (DDP), carmustine, and dacarbazine, and we have previously reported that there is a highly synergistic interaction between TAM and DDP with respect to the cytotoxic effect against the human melanoma cell line T-289 (E."7.68Tamoxifen modulation of cisplatin sensitivity in human malignant melanoma cells. ( Albright, KD; Christen, RD; Howell, SB; Jones, JA; McClay, EF, 1993)
"Tamoxifen (TAM) markedly increases the response rate of malignant melanoma to treatment with cisplatin (DDP), carmustine, and dacarbazine, and we have previously reported that there is a highly synergistic interaction between TAM and DDP with respect to the cytotoxic effect against the human melanoma cell line T-289 (E."3.68Tamoxifen modulation of cisplatin sensitivity in human malignant melanoma cells. ( Albright, KD; Christen, RD; Howell, SB; Jones, JA; McClay, EF, 1993)
"Two drugs known to inhibit the action of calmodulin, prochlorperazine offP) and N-(6-aminohexyl)-5-chloro-1-napthalene sulfonamide (W7), were investigated for their ability to control cell proliferation in murine B16 melanoma cells in culture."3.67Effects of extracellular calmodulin and calmodulin antagonists on B16 melanoma cell growth. ( Bleehen, SS; Mac Neil, S; Senior, HJ; Tomlinson, S; Walker, SW, 1984)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19905 (83.33)18.7374
1990's1 (16.67)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Walker, SW2
Mac Neil, S2
Senior, HJ2
Bleehen, SS2
Tomlinson, S2
Ito, H1
Hidaka, H1
McClay, EF1
Albright, KD1
Jones, JA1
Christen, RD1
Howell, SB1
Kitagawa, T1
Amano, F1
Akamatsu, Y1
Lönn, U1
Lönn, S1

Other Studies

6 other studies available for w 7 and Melanoma

ArticleYear
Calmodulin activation of cyclic AMP phosphodiesterase in the B16 mouse melanoma.
    The Biochemical journal, 1984, May-01, Volume: 219, Issue:3

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Calmodulin; Cells, Cultured; Cyclic AMP; Enzyme Activa

1984
Antitumor effect of calmodulin antagonist against MH-134 hepatoma, Ehrlich ascites carcinoma and B-16 melanocarcinoma in mice.
    European journal of cancer & clinical oncology, 1983, Volume: 19, Issue:8

    Topics: Animals; Calmodulin; Carcinoma, Ehrlich Tumor; Liver Neoplasms, Experimental; Melanoma; Mice; Neopla

1983
Effects of extracellular calmodulin and calmodulin antagonists on B16 melanoma cell growth.
    The Journal of investigative dermatology, 1984, Volume: 83, Issue:1

    Topics: Animals; Calmodulin; Cell Line; Cells, Cultured; Culture Media; DNA, Neoplasm; Dose-Response Relatio

1984
Tamoxifen modulation of cisplatin sensitivity in human malignant melanoma cells.
    Cancer research, 1993, Apr-01, Volume: 53, Issue:7

    Topics: Antineoplastic Agents; Calmodulin; Cell Cycle; Cisplatin; Drug Resistance; Drug Synergism; Enzyme In

1993
External ATP-induced passive permeability change and cell lysis of cultured transformed cells: action in serum-containing growth media.
    Biochimica et biophysica acta, 1988, Jun-22, Volume: 941, Issue:2

    Topics: Adenosine Triphosphate; Animals; Blood; Calcium; Calmodulin; Cell Membrane Permeability; Cell Surviv

1988
W-7, a calmodulin inhibitor, potentiates dacarbazine cytotoxicity in human neoplastic cells.
    International journal of cancer, 1987, May-15, Volume: 39, Issue:5

    Topics: Calmodulin; Cell Division; Cell Line; Cell Survival; Dacarbazine; DNA Repair; DNA Replication; DNA,

1987