Page last updated: 2024-11-05

w 7 and Long QT Syndrome

w 7 has been researched along with Long QT Syndrome in 2 studies

W 7: RN given refers to parent cpd; structure; calmodulin antagonist

Long QT Syndrome: A condition that is characterized by episodes of fainting (SYNCOPE) and varying degree of ventricular arrhythmia as indicated by the prolonged QT interval. The inherited forms are caused by mutation of genes encoding cardiac ion channel proteins. The two major forms are ROMANO-WARD SYNDROME and JERVELL-LANGE NIELSEN SYNDROME.

Research Excerpts

ExcerptRelevanceReference
"AV block was created in dogs to induce ventricular remodeling, including enhanced susceptibility to dofetilide-induced torsades de pointes arrhythmias."1.38Relevance of calmodulin/CaMKII activation for arrhythmogenesis in the AV block dog. ( Antoons, G; Beekman, JD; Bourgonje, VJ; de Windt, LJ; Houtman, MJ; Miedema, LF; Schoenmakers, M; Sipido, K; van der Nagel, R; van Veen, TA; Vos, MA, 2012)
"The ventricular arrhythmia torsade de pointes (TdP) occurs after QT interval prolongation and is associated with sudden cardiac death."1.30Systemic administration of calmodulin antagonist W-7 or protein kinase A inhibitor H-8 prevents torsade de pointes in rabbits. ( Anderson, ME; Mazur, A; Roden, DM, 1999)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (50.00)18.2507
2000's0 (0.00)29.6817
2010's1 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bourgonje, VJ1
Schoenmakers, M1
Beekman, JD1
van der Nagel, R1
Houtman, MJ1
Miedema, LF1
Antoons, G1
Sipido, K1
de Windt, LJ1
van Veen, TA1
Vos, MA1
Mazur, A1
Roden, DM1
Anderson, ME1

Other Studies

2 other studies available for w 7 and Long QT Syndrome

ArticleYear
Relevance of calmodulin/CaMKII activation for arrhythmogenesis in the AV block dog.
    Heart rhythm, 2012, Volume: 9, Issue:11

    Topics: Animals; Arrhythmias, Cardiac; Atrioventricular Block; Benzylamines; Calcineurin; Calcium-Binding Pr

2012
Systemic administration of calmodulin antagonist W-7 or protein kinase A inhibitor H-8 prevents torsade de pointes in rabbits.
    Circulation, 1999, Dec-14, Volume: 100, Issue:24

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1999