w 7 has been researched along with Disease Models, Animal in 9 studies
W 7: RN given refers to parent cpd; structure; calmodulin antagonist
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "AV block was created in dogs to induce ventricular remodeling, including enhanced susceptibility to dofetilide-induced torsades de pointes arrhythmias." | 1.38 | Relevance of calmodulin/CaMKII activation for arrhythmogenesis in the AV block dog. ( Antoons, G; Beekman, JD; Bourgonje, VJ; de Windt, LJ; Houtman, MJ; Miedema, LF; Schoenmakers, M; Sipido, K; van der Nagel, R; van Veen, TA; Vos, MA, 2012) |
| "The ventricular arrhythmia torsade de pointes (TdP) occurs after QT interval prolongation and is associated with sudden cardiac death." | 1.30 | Systemic administration of calmodulin antagonist W-7 or protein kinase A inhibitor H-8 prevents torsade de pointes in rabbits. ( Anderson, ME; Mazur, A; Roden, DM, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (33.33) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 3 (33.33) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Alzoubi, KH | 1 |
| Alkadhi, KA | 1 |
| Kijtawornrat, A | 1 |
| Ziolo, MT | 1 |
| Nishijima, Y | 1 |
| Roche, BM | 1 |
| Hamlin, RL | 1 |
| Tsuji, Y | 1 |
| Hojo, M | 1 |
| Voigt, N | 1 |
| El-Armouche, A | 1 |
| Inden, Y | 1 |
| Murohara, T | 1 |
| Dobrev, D | 1 |
| Nattel, S | 1 |
| Kodama, I | 1 |
| Kamiya, K | 1 |
| Bourgonje, VJ | 1 |
| Schoenmakers, M | 1 |
| Beekman, JD | 1 |
| van der Nagel, R | 1 |
| Houtman, MJ | 1 |
| Miedema, LF | 1 |
| Antoons, G | 1 |
| Sipido, K | 1 |
| de Windt, LJ | 1 |
| van Veen, TA | 1 |
| Vos, MA | 1 |
| Gadano, AC | 2 |
| Sogni, P | 2 |
| Yang, S | 1 |
| Cailmail, S | 1 |
| Moreau, R | 2 |
| Nepveux, P | 1 |
| Couturier, D | 1 |
| Lebrec, D | 2 |
| Heller, J | 1 |
| Bories, PN | 1 |
| Mazur, A | 1 |
| Roden, DM | 2 |
| Anderson, ME | 2 |
| Gbadebo, TD | 1 |
| Trimble, RW | 1 |
| Khoo, MS | 1 |
| Temple, J | 1 |
9 other studies available for w 7 and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Calmodulin and guanylyl cyclase inhibitors block the in vivo expression of gLTP in sympathetic ganglia from chronically stressed rats.
Topics: Aminoquinolines; Animals; Calmodulin; Disease Models, Animal; Electric Stimulation; Enzyme Inhibitor | 2009 |
Effects of sarcolemmal Ca(2+) entry, ryanodine function, and kinase inhibitors on a rabbit model of heart failure.
Topics: Animals; Anti-Arrhythmia Agents; Benzylamines; Disease Models, Animal; Heart Failure; Isoquinolines; | 2010 |
Ca(2+)-related signaling and protein phosphorylation abnormalities play central roles in a new experimental model of electrical storm.
Topics: Animals; Calcium Channels, L-Type; Calcium Signaling; Calcium-Binding Proteins; Calcium-Calmodulin-D | 2011 |
Relevance of calmodulin/CaMKII activation for arrhythmogenesis in the AV block dog.
Topics: Animals; Arrhythmias, Cardiac; Atrioventricular Block; Benzylamines; Calcineurin; Calcium-Binding Pr | 2012 |
Endothelial calcium-calmodulin dependent nitric oxide synthase in the in vitro vascular hyporeactivity of portal hypertensive rats.
Topics: Animals; Aorta, Thoracic; Calcium-Calmodulin-Dependent Protein Kinases; Cyclooxygenase Inhibitors; D | 1997 |
Vascular nitric oxide production during the development of two experimental models of portal hypertension.
Topics: Animals; Aorta, Thoracic; Disease Models, Animal; Guanidines; Hypertension, Portal; In Vitro Techniq | 1999 |
Systemic administration of calmodulin antagonist W-7 or protein kinase A inhibitor H-8 prevents torsade de pointes in rabbits.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1999 |
Calmodulin inhibitor W-7 unmasks a novel electrocardiographic parameter that predicts initiation of torsade de pointes.
Topics: Animals; Arrhythmias, Cardiac; Calmodulin; Disease Models, Animal; Electrocardiography; Enzyme Inhib | 2002 |