vulm-1457 and Arrhythmias--Cardiac

vulm-1457 has been researched along with Arrhythmias--Cardiac* in 1 studies

Other Studies

1 other study(ies) available for vulm-1457 and Arrhythmias--Cardiac

Article	Year
Protective effect of simvastatin and VULM 1457 in ischaemic-reperfused myocardium of the diabetic-hypercholesterolemic rats. Die Pharmazie, 2006, Volume: 61, Issue:9 This study examined the effects of simvastatin (10 mg/ kg) and VULM 1457 (50 mg/kg), an ACAT inhibitor, in the heart model of 6 min ischemia followed by 10 min reperfusion injury in the diabetic-hypercholesterolaemic (DM-HCH) rats. In the DM-HCH rats, the incidence of ventricular tachycardia (VT) had a tendency to be increased, while ventricular fibrillation (VF) occurred in all diseased rats (p < 0.01). Simvastatin and VULM 1457 with the shown hypolipidemic effect, significantly (p < 0.01) suppressed a formation of VF (38% and 29%; respectively). Topics: Animals; Arrhythmias, Cardiac; Blood Glucose; Cholesterol; Cholesterol, Dietary; Clofibrate; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Male; Myocardial Reperfusion Injury; Rats; Rats, Wistar; Reperfusion Injury; Simvastatin; Sterol O-Acyltransferase	2006

Article

Year

Protective effect of simvastatin and VULM 1457 in ischaemic-reperfused myocardium of the diabetic-hypercholesterolemic rats.

Die Pharmazie, 2006, Volume: 61, Issue:9

This study examined the effects of simvastatin (10 mg/ kg) and VULM 1457 (50 mg/kg), an ACAT inhibitor, in the heart model of 6 min ischemia followed by 10 min reperfusion injury in the diabetic-hypercholesterolaemic (DM-HCH) rats. In the DM-HCH rats, the incidence of ventricular tachycardia (VT) had a tendency to be increased, while ventricular fibrillation (VF) occurred in all diseased rats (p < 0.01). Simvastatin and VULM 1457 with the shown hypolipidemic effect, significantly (p < 0.01) suppressed a formation of VF (38% and 29%; respectively).

Topics: Animals; Arrhythmias, Cardiac; Blood Glucose; Cholesterol; Cholesterol, Dietary; Clofibrate; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Male; Myocardial Reperfusion Injury; Rats; Rats, Wistar; Reperfusion Injury; Simvastatin; Sterol O-Acyltransferase

2006