vortioxetine has been researched along with Renal-Insufficiency* in 1 studies
1 trial(s) available for vortioxetine and Renal-Insufficiency
Article | Year |
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Effects of Intrinsic Factors on the Clinical Pharmacokinetics of Vortioxetine.
Vortioxetine is an antidepressant agent with multimodal activity that is approved for the treatment of major depressive disorder at doses of 5 to 20 mg once daily. Vortioxetine is a medium-clearance drug that undergoes extensive metabolism via several cytochrome P450 isozymes. A series of single- and multiple-dose pharmacokinetic studies were performed to evaluate the impact of intrinsic (ie, subject-related) factors, such as age, sex, race, and renal and hepatic function, on the pharmacokinetics of vortioxetine. The point estimates on the ratios and their 90% confidence intervals (CIs) for the central values of AUC (area under the concentration-time curve) and C Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Antidepressive Agents; Dose-Response Relationship, Drug; Ethnicity; Female; Healthy Volunteers; Hepatic Insufficiency; Humans; Male; Middle Aged; Renal Insufficiency; Sex Factors; Single-Blind Method; Vortioxetine; Young Adult | 2018 |