vorinostat has been researched along with Thyroid Cancer, Anaplastic in 3 studies
Vorinostat: A hydroxamic acid and anilide derivative that acts as a HISTONE DEACETYLASE inhibitor. It is used in the treatment of CUTANEOUS T-CELL LYMPHOMA and SEZARY SYNDROME.
vorinostat : A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Anaplastic thyroid carcinoma is a highly aggressive undifferentiated carcinoma with a mortality rate near 100% due to an assortment of genomic abnormalities which impede the success of therapeutic options." | 1.42 | RhoB upregulation leads to either apoptosis or cytostasis through differential target selection. ( Bok, I; Copland, JA; Marlow, LA; Smallridge, RC, 2015) |
| " The objective of this study was to investigate the effects of 1,25(OH)(2)D(3) and the superagonistic analog CD578 in anaplastic thyroid cancer, alone or in combination with paclitaxel, a taxane, and suberoylanilide hydroxamic acid (SAHA), a potent histone deacetylase inhibitor with promising effects in undifferentiated thyroid cancer." | 1.37 | 1,25-dihydroxyvitamin D3 and a superagonistic analog in combination with paclitaxel or suberoylanilide hydroxamic acid have potent antiproliferative effects on anaplastic thyroid cancer. ( Bouillon, R; Clinckspoor, I; Decallonne, B; Korch, C; Mathieu, C; Overbergh, L; Verlinden, L; Verstuyf, A, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Marlow, LA | 1 |
| Bok, I | 1 |
| Smallridge, RC | 1 |
| Copland, JA | 1 |
| Kim, SH | 1 |
| Kang, JG | 1 |
| Kim, CS | 1 |
| Ihm, SH | 1 |
| Choi, MG | 1 |
| Yoo, HJ | 1 |
| Lee, SJ | 1 |
| Clinckspoor, I | 1 |
| Verlinden, L | 1 |
| Overbergh, L | 1 |
| Korch, C | 1 |
| Bouillon, R | 1 |
| Mathieu, C | 1 |
| Verstuyf, A | 1 |
| Decallonne, B | 1 |
3 other studies available for vorinostat and Thyroid Cancer, Anaplastic
| Article | Year |
|---|---|
RhoB upregulation leads to either apoptosis or cytostasis through differential target selection.
Topics: Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apopto | 2015 |
The heat shock protein 90 inhibitor SNX5422 has a synergistic activity with histone deacetylase inhibitors in induction of death of anaplastic thyroid carcinoma cells.
Topics: Antineoplastic Agents; Apoptosis; Benzamides; Caspase 3; Cell Line, Tumor; Cell Survival; Drug Syner | 2016 |
1,25-dihydroxyvitamin D3 and a superagonistic analog in combination with paclitaxel or suberoylanilide hydroxamic acid have potent antiproliferative effects on anaplastic thyroid cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Calcitriol; Cell Cycle; Cell Line, Tumor; Cell Proli | 2011 |