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vorinostat and Thyroid Cancer, Anaplastic

vorinostat has been researched along with Thyroid Cancer, Anaplastic in 3 studies

Vorinostat: A hydroxamic acid and anilide derivative that acts as a HISTONE DEACETYLASE inhibitor. It is used in the treatment of CUTANEOUS T-CELL LYMPHOMA and SEZARY SYNDROME.
vorinostat : A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).

Research Excerpts

ExcerptRelevanceReference
"Anaplastic thyroid carcinoma is a highly aggressive undifferentiated carcinoma with a mortality rate near 100% due to an assortment of genomic abnormalities which impede the success of therapeutic options."1.42RhoB upregulation leads to either apoptosis or cytostasis through differential target selection. ( Bok, I; Copland, JA; Marlow, LA; Smallridge, RC, 2015)
" The objective of this study was to investigate the effects of 1,25(OH)(2)D(3) and the superagonistic analog CD578 in anaplastic thyroid cancer, alone or in combination with paclitaxel, a taxane, and suberoylanilide hydroxamic acid (SAHA), a potent histone deacetylase inhibitor with promising effects in undifferentiated thyroid cancer."1.371,25-dihydroxyvitamin D3 and a superagonistic analog in combination with paclitaxel or suberoylanilide hydroxamic acid have potent antiproliferative effects on anaplastic thyroid cancer. ( Bouillon, R; Clinckspoor, I; Decallonne, B; Korch, C; Mathieu, C; Overbergh, L; Verlinden, L; Verstuyf, A, 2011)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Marlow, LA1
Bok, I1
Smallridge, RC1
Copland, JA1
Kim, SH1
Kang, JG1
Kim, CS1
Ihm, SH1
Choi, MG1
Yoo, HJ1
Lee, SJ1
Clinckspoor, I1
Verlinden, L1
Overbergh, L1
Korch, C1
Bouillon, R1
Mathieu, C1
Verstuyf, A1
Decallonne, B1

Other Studies

3 other studies available for vorinostat and Thyroid Cancer, Anaplastic

ArticleYear
RhoB upregulation leads to either apoptosis or cytostasis through differential target selection.
    Endocrine-related cancer, 2015, Volume: 22, Issue:5

    Topics: Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apopto

2015
The heat shock protein 90 inhibitor SNX5422 has a synergistic activity with histone deacetylase inhibitors in induction of death of anaplastic thyroid carcinoma cells.
    Endocrine, 2016, Volume: 51, Issue:2

    Topics: Antineoplastic Agents; Apoptosis; Benzamides; Caspase 3; Cell Line, Tumor; Cell Survival; Drug Syner

2016
1,25-dihydroxyvitamin D3 and a superagonistic analog in combination with paclitaxel or suberoylanilide hydroxamic acid have potent antiproliferative effects on anaplastic thyroid cancer.
    The Journal of steroid biochemistry and molecular biology, 2011, Volume: 124, Issue:1-2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Calcitriol; Cell Cycle; Cell Line, Tumor; Cell Proli

2011