Page last updated: 2024-11-04

vorinostat and Rhabdoid Tumor

vorinostat has been researched along with Rhabdoid Tumor in 3 studies

Vorinostat: A hydroxamic acid and anilide derivative that acts as a HISTONE DEACETYLASE inhibitor. It is used in the treatment of CUTANEOUS T-CELL LYMPHOMA and SEZARY SYNDROME.
vorinostat : A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).

Rhabdoid Tumor: A rare but highly lethal childhood tumor found almost exclusively in infants. Histopathologically, it resembles RHABDOMYOSARCOMA but the tumor cells are not of myogenic origin. Although it arises primarily in the kidney, it may be found in other parts of the body. The rhabdoid cytomorphology is believed to be the expression of a very primitive malignant cell. (From Holland et al., Cancer Medicine, 3d ed, p2210)

Research Excerpts

ExcerptRelevanceReference
"Our data demonstrate that HDAC inhibitor treatment in combination with fenretinide or conventional chemotherapy is a promising tool for the treatment of chemoresistant rhabdoid tumors."7.79The histone deacetylase inhibitor SAHA acts in synergism with fenretinide and doxorubicin to control growth of rhabdoid tumor cells. ( Borchert, C; Eveslage, M; Frühwald, M; Görlich, D; Hasselblatt, M; Jung, M; Jürgens, H; Kerl, K; Kool, M; Meisterernst, M; Moreno, N; Ries, D; Unland, R, 2013)
"Our data demonstrate that HDAC inhibitor treatment in combination with fenretinide or conventional chemotherapy is a promising tool for the treatment of chemoresistant rhabdoid tumors."3.79The histone deacetylase inhibitor SAHA acts in synergism with fenretinide and doxorubicin to control growth of rhabdoid tumor cells. ( Borchert, C; Eveslage, M; Frühwald, M; Görlich, D; Hasselblatt, M; Jung, M; Jürgens, H; Kerl, K; Kool, M; Meisterernst, M; Moreno, N; Ries, D; Unland, R, 2013)
" The aim of the study presented here was to analyze the effects of a pharmacological inhibition of EZH2 alone and in combination with other anticancer drugs on RTs cells in vitro."1.42Analysis of the antiproliferative effects of 3-deazaneoplanocin A in combination with standard anticancer agents in rhabdoid tumor cell lines. ( Borchardt, C; Clemens, D; Dirksen, U; Frühwald, MC; Kool, M; Unland, R, 2015)
"Potential radiosensitization by SAHA was assessed in MRT xenografts by analysis of tumor growth delay, necrosis (HE), apoptosis (TUNEL), proliferation (ki-67) and γH2AX expression as well as dynamic 18F-Fluorodeoxyglucose Positron Emission Tomography (18F-FDG -PET) after treatment with either SAHA alone, single-dose (10 Gy) or fractionated XRT (3 × 3Gy) solely as well as in combination with SAHA compared to controls."1.38In vivo efficacy of the histone deacetylase inhibitor suberoylanilide hydroxamic acid in combination with radiotherapy in a malignant rhabdoid tumor mouse model. ( Battmann, C; Bischof, M; Debus, J; Ehemann, V; Haberkorn, U; Huber, PE; Kulozik, AE; Oertel, S; Perez, RL; Stenzinger, A; Thiemann, M; Weber, KJ; Weichert, W, 2012)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kerl, K1
Ries, D1
Unland, R2
Borchert, C1
Moreno, N1
Hasselblatt, M1
Jürgens, H1
Kool, M2
Görlich, D1
Eveslage, M1
Jung, M1
Meisterernst, M1
Frühwald, M1
Borchardt, C1
Clemens, D1
Dirksen, U1
Frühwald, MC1
Thiemann, M1
Oertel, S1
Ehemann, V1
Weichert, W1
Stenzinger, A1
Bischof, M1
Weber, KJ1
Perez, RL1
Haberkorn, U1
Kulozik, AE1
Debus, J1
Huber, PE1
Battmann, C1

Other Studies

3 other studies available for vorinostat and Rhabdoid Tumor

ArticleYear
The histone deacetylase inhibitor SAHA acts in synergism with fenretinide and doxorubicin to control growth of rhabdoid tumor cells.
    BMC cancer, 2013, Jun-13, Volume: 13

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Cell Line, Tumor; Doxo

2013
Analysis of the antiproliferative effects of 3-deazaneoplanocin A in combination with standard anticancer agents in rhabdoid tumor cell lines.
    Anti-cancer drugs, 2015, Volume: 26, Issue:3

    Topics: Adenosine; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Azacitidine; Cell Line, Tumor;

2015
In vivo efficacy of the histone deacetylase inhibitor suberoylanilide hydroxamic acid in combination with radiotherapy in a malignant rhabdoid tumor mouse model.
    Radiation oncology (London, England), 2012, Mar-29, Volume: 7

    Topics: Animals; Apoptosis; Chemoradiotherapy; Disease Models, Animal; Female; Flow Cytometry; Histone Deace

2012