vorinostat has been researched along with Rett Syndrome in 3 studies
Vorinostat: A hydroxamic acid and anilide derivative that acts as a HISTONE DEACETYLASE inhibitor. It is used in the treatment of CUTANEOUS T-CELL LYMPHOMA and SEZARY SYNDROME.
vorinostat : A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).
Rett Syndrome: An inherited neurological developmental disorder that is associated with X-LINKED INHERITANCE and may be lethal in utero to hemizygous males. The affected female is normal until the age of 6-25 months when progressive loss of voluntary control of hand movements and communication skills; ATAXIA; SEIZURES; autistic behavior; intermittent HYPERVENTILATION; and HYPERAMMONEMIA appear. (From Menkes, Textbook of Child Neurology, 5th ed, p199)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Rett Syndrome is an X-linked progressive neurological disorder caused by inactivation of one allele of the MECP2 gene." | 1.37 | Clonal Rett Syndrome cell lines to test compounds for activation of wild-type MeCP2 expression. ( Corey, DR; Sakurai, F; Yu, D, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yu, D | 1 |
| Sakurai, F | 1 |
| Corey, DR | 1 |
| Adachi, M | 1 |
| Autry, AE | 1 |
| Covington, HE | 1 |
| Monteggia, LM | 1 |
| Wu, SH | 1 |
| Camarena, V | 1 |
3 other studies available for vorinostat and Rett Syndrome
| Article | Year |
|---|---|
Clonal Rett Syndrome cell lines to test compounds for activation of wild-type MeCP2 expression.
Topics: Clone Cells; Epigenesis, Genetic; Fibroblasts; Gene Expression Profiling; Humans; Methyl-CpG-Binding | 2011 |
MeCP2-mediated transcription repression in the basolateral amygdala may underlie heightened anxiety in a mouse model of Rett syndrome.
Topics: Amygdala; Animals; Anxiety; Conditioning, Psychological; Disease Models, Animal; Enzyme Inhibitors; | 2009 |
MeCP2 function in the basolateral amygdala in Rett syndrome.
Topics: Acetylation; Amygdala; Animals; Anxiety; Enzyme Inhibitors; Fear; Gene Expression Regulation; Histon | 2009 |