vorinostat has been researched along with Retinoblastoma in 2 studies
Vorinostat: A hydroxamic acid and anilide derivative that acts as a HISTONE DEACETYLASE inhibitor. It is used in the treatment of CUTANEOUS T-CELL LYMPHOMA and SEZARY SYNDROME.
vorinostat : A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).
Retinoblastoma: A malignant tumor arising from the nuclear layer of the retina that is the most common primary tumor of the eye in children. The tumor tends to occur in early childhood or infancy and may be present at birth. The majority are sporadic, but the condition may be transmitted as an autosomal dominant trait. Histologic features include dense cellularity, small round polygonal cells, and areas of calcification and necrosis. An abnormal pupil reflex (leukokoria); NYSTAGMUS, PATHOLOGIC; STRABISMUS; and visual loss represent common clinical characteristics of this condition. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2104)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Vorinostat has demonstrated significant anticancer activity against hematologic and solid tumors at doses well tolerated by patients and has been approved for the treatment of patients with cutaneous T-cell lymphoma." | 1.35 | Molecular sequelae of histone deacetylase inhibition in human retinoblastoma cell lines: clinical implications. ( Kotoula, V; Marks, PA; McMullan, C; Miller, JW; Mitsiades, CS; Mitsiades, N; Negri, J; Poulaki, V, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Poulaki, V | 1 |
| Mitsiades, CS | 1 |
| Kotoula, V | 1 |
| Negri, J | 1 |
| McMullan, C | 1 |
| Miller, JW | 1 |
| Marks, PA | 1 |
| Mitsiades, N | 1 |
| Dalgard, CL | 1 |
| Van Quill, KR | 1 |
| O'Brien, JM | 1 |
2 other studies available for vorinostat and Retinoblastoma
| Article | Year |
|---|---|
Molecular sequelae of histone deacetylase inhibition in human retinoblastoma cell lines: clinical implications.
Topics: Acetylation; Apoptosis; Bromodeoxyuridine; Caspases; Cell Line, Tumor; Cell Proliferation; Cinnamate | 2009 |
Evaluation of the in vitro and in vivo antitumor activity of histone deacetylase inhibitors for the therapy of retinoblastoma.
Topics: Animals; Annexin A5; Antineoplastic Agents; Apoptosis; Benzamides; Blotting, Western; Caspase 3; Cas | 2008 |