Page last updated: 2024-11-04

vorinostat and Retinitis Pigmentosa

vorinostat has been researched along with Retinitis Pigmentosa in 2 studies

Vorinostat: A hydroxamic acid and anilide derivative that acts as a HISTONE DEACETYLASE inhibitor. It is used in the treatment of CUTANEOUS T-CELL LYMPHOMA and SEZARY SYNDROME.
vorinostat : A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).

Retinitis Pigmentosa: Hereditary, progressive degeneration of the retina due to death of ROD PHOTORECEPTORS initially and subsequent death of CONE PHOTORECEPTORS. It is characterized by deposition of pigment in the retina.

Research Excerpts

ExcerptRelevanceReference
"Recent reports linking HDAC6 to mitochondrial turnover and neurodegeneration led us to hypothesize that an inhibitor such as Vorinostat (suberoylanilide hydroxamic acid, SAHA) may reduce mitochondrial damage found in retinitis pigmentosa (RP), a progressive neurodegenerative disease of the eye."4.02SAHA is neuroprotective in in vitro and in situ models of retinitis pigmentosa. ( Bandyopadhyay, M; Beeson, CC; Nasarre, C; Perron, NR; Rohrer, B, 2021)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's2 (100.00)2.80

Authors

AuthorsStudies
Dong, Y1
Yan, J1
Xu, W1
Paquet-Durand, F1
Hu, Z1
Jiao, K1
Perron, NR1
Nasarre, C1
Bandyopadhyay, M1
Beeson, CC1
Rohrer, B1

Other Studies

2 other studies available for vorinostat and Retinitis Pigmentosa

ArticleYear
HDAC inhibition delays photoreceptor loss in
    PeerJ, 2023, Volume: 11

    Topics: Animals; Histone Deacetylases; Mice; Photoreceptor Cells; Poly(ADP-ribose) Polymerase Inhibitors; Po

2023
SAHA is neuroprotective in in vitro and in situ models of retinitis pigmentosa.
    Molecular vision, 2021, Volume: 27

    Topics: Animals; Blotting, Western; Cell Line; Cell Survival; Disease Models, Animal; Histone Deacetylase In

2021