vorinostat has been researched along with Retinitis Pigmentosa in 2 studies
Vorinostat: A hydroxamic acid and anilide derivative that acts as a HISTONE DEACETYLASE inhibitor. It is used in the treatment of CUTANEOUS T-CELL LYMPHOMA and SEZARY SYNDROME.
vorinostat : A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).
Retinitis Pigmentosa: Hereditary, progressive degeneration of the retina due to death of ROD PHOTORECEPTORS initially and subsequent death of CONE PHOTORECEPTORS. It is characterized by deposition of pigment in the retina.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Recent reports linking HDAC6 to mitochondrial turnover and neurodegeneration led us to hypothesize that an inhibitor such as Vorinostat (suberoylanilide hydroxamic acid, SAHA) may reduce mitochondrial damage found in retinitis pigmentosa (RP), a progressive neurodegenerative disease of the eye." | 4.02 | SAHA is neuroprotective in in vitro and in situ models of retinitis pigmentosa. ( Bandyopadhyay, M; Beeson, CC; Nasarre, C; Perron, NR; Rohrer, B, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 2 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dong, Y | 1 |
| Yan, J | 1 |
| Xu, W | 1 |
| Paquet-Durand, F | 1 |
| Hu, Z | 1 |
| Jiao, K | 1 |
| Perron, NR | 1 |
| Nasarre, C | 1 |
| Bandyopadhyay, M | 1 |
| Beeson, CC | 1 |
| Rohrer, B | 1 |
2 other studies available for vorinostat and Retinitis Pigmentosa
| Article | Year |
|---|---|
HDAC inhibition delays photoreceptor loss in
Topics: Animals; Histone Deacetylases; Mice; Photoreceptor Cells; Poly(ADP-ribose) Polymerase Inhibitors; Po | 2023 |
SAHA is neuroprotective in in vitro and in situ models of retinitis pigmentosa.
Topics: Animals; Blotting, Western; Cell Line; Cell Survival; Disease Models, Animal; Histone Deacetylase In | 2021 |