vorinostat has been researched along with Pulmonary Fibrosis in 1 studies
Vorinostat: A hydroxamic acid and anilide derivative that acts as a HISTONE DEACETYLASE inhibitor. It is used in the treatment of CUTANEOUS T-CELL LYMPHOMA and SEZARY SYNDROME.
vorinostat : A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).
Pulmonary Fibrosis: A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Idiopathic pulmonary fibrosis (IPF) is a deadly disease characterized by chronic inflammation and excessive collagen accumulation in the lung." | 1.39 | Histone deacetylase inhibition downregulates collagen 3A1 in fibrotic lung fibroblasts. ( Hock, T; Liu, H; Sanders, YY; Thannickal, VJ; Zhang, X, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, X | 1 |
| Liu, H | 1 |
| Hock, T | 1 |
| Thannickal, VJ | 1 |
| Sanders, YY | 1 |
1 other study available for vorinostat and Pulmonary Fibrosis
| Article | Year |
|---|---|
Histone deacetylase inhibition downregulates collagen 3A1 in fibrotic lung fibroblasts.
Topics: Animals; Cells, Cultured; Chromatin; Collagen Type III; Down-Regulation; Fibroblasts; Histone Deacet | 2013 |