vorinostat has been researched along with Pregnancy in 12 studies
Vorinostat: A hydroxamic acid and anilide derivative that acts as a HISTONE DEACETYLASE inhibitor. It is used in the treatment of CUTANEOUS T-CELL LYMPHOMA and SEZARY SYNDROME.
vorinostat : A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Depression is a disabling psychiatric disorder affecting millions of people all around the world." | 1.62 | SAHA Improves Depressive Symptoms, Cognitive Impairment and Oxidative Stress: Rise of a New Antidepressant Class. ( Amini-Khoei, H; Dehpour, AR; Ershadi, ASB; Hosseini, MJ, 2021) |
| "Sevoflurane is a widely used volatile anesthetic in clinical practice." | 1.51 | Suberoylanilide hydroxamic acid (SAHA) alleviates the learning and memory impairment in rat offspring caused by maternal sevoflurane exposure during late gestation. ( Feng, N; Hu, Y; Li, M; Liu, Y; Liu, Z; Luo, F; Wu, L; Xu, L; Yu, Q; Zhao, W, 2019) |
| "SAHA and TSA could inhibit total HDAC activity and placental HDAC1/2/3 expression both in Bewo and JAR, but displayed a transient induction of HDAC mRNA or protein level after being treated at low dosage or prolonged exposure to drugs." | 1.46 | The effect of histone deacetylase inhibition on the expression of P-glycoprotein in human placental trophoblast cell lines. ( Duan, H; Hua, Y; Li, Q; Li, Y; Qiu, D; Wang, C; Wang, T; Zhang, Y; Zhou, K, 2017) |
| " Our previous studies have demonstrated the social cognition deficits observed in this model, a major core symptom of ASD, to be ameliorated following chronic administration of histone deacetylase (HDAC) inhibitors." | 1.40 | Pentyl-4-yn-VPA, a histone deacetylase inhibitor, ameliorates deficits in social behavior and cognition in a rodent model of autism spectrum disorders. ( Cassidy, AW; Foley, AG; Regan, CM, 2014) |
| "Animals were dosed on Gestation Days 6-20 or 7-20, respectively, with litter/fetal parameters evaluated on GD 21 and 28, respectively." | 1.34 | Assessment of developmental toxicity of vorinostat, a histone deacetylase inhibitor, in Sprague-Dawley rats and Dutch Belted rabbits. ( Kerr, JS; Turner, KJ; Wise, LD, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (16.67) | 29.6817 |
| 2010's | 8 (66.67) | 24.3611 |
| 2020's | 2 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Song, XY | 1 |
| Liu, XW | 1 |
| Wang, J | 1 |
| Ershadi, ASB | 1 |
| Amini-Khoei, H | 1 |
| Hosseini, MJ | 1 |
| Dehpour, AR | 1 |
| Jin, L | 1 |
| Guo, Q | 1 |
| Zhu, HY | 1 |
| Xing, XX | 1 |
| Zhang, GL | 1 |
| Xuan, MF | 1 |
| Luo, QR | 1 |
| Luo, ZB | 1 |
| Wang, JX | 1 |
| Choe, HM | 1 |
| Paek, HJ | 1 |
| Yin, XJ | 1 |
| Kang, JD | 1 |
| Lin, J | 1 |
| Wang, S | 1 |
| Feng, Y | 1 |
| Zhao, W | 4 |
| Luo, F | 2 |
| Feng, N | 2 |
| Melchior, M | 1 |
| Juif, PE | 1 |
| Gazzo, G | 1 |
| Petit-Demoulière, N | 1 |
| Chavant, V | 1 |
| Lacaud, A | 1 |
| Goumon, Y | 1 |
| Charlet, A | 1 |
| Lelièvre, V | 1 |
| Poisbeau, P | 1 |
| Yu, Q | 1 |
| Hu, Y | 1 |
| Liu, Z | 1 |
| Li, M | 1 |
| Xu, L | 1 |
| Wu, L | 1 |
| Liu, Y | 1 |
| Foley, AG | 1 |
| Cassidy, AW | 1 |
| Regan, CM | 1 |
| Kim, MJ | 1 |
| Oh, HJ | 1 |
| Kim, GA | 1 |
| Suh, HN | 1 |
| Jo, YK | 1 |
| Choi, YB | 1 |
| Kim, DH | 1 |
| Han, HJ | 1 |
| Lee, BC | 1 |
| Duan, H | 1 |
| Wang, C | 1 |
| Zhou, K | 1 |
| Wang, T | 1 |
| Li, Y | 1 |
| Qiu, D | 1 |
| Li, Q | 1 |
| Zhang, Y | 1 |
| Hua, Y | 1 |
| Chen, SH | 1 |
| Wu, HM | 1 |
| Ossola, B | 1 |
| Schendzielorz, N | 1 |
| Wilson, BC | 1 |
| Chu, CH | 1 |
| Chen, SL | 1 |
| Wang, Q | 1 |
| Zhang, D | 1 |
| Qian, L | 1 |
| Li, X | 1 |
| Hong, JS | 1 |
| Lu, RB | 1 |
| Wise, LD | 1 |
| Turner, KJ | 1 |
| Kerr, JS | 1 |
| Giavini, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A 12-weeks, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy, Safety and Related Mechanism of Sulforaphane in Treatment of Autism Spectrum Disorder[NCT02879110] | 110 participants (Actual) | Interventional | 2016-08-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
12 other studies available for vorinostat and Pregnancy
| Article | Year |
|---|---|
Suberoylanilide hydroxamic acid (SAHA) attenuates memory impairment in the offspring of rats exposed to sevoflurane anesthesia.
Topics: Anesthesia; Animals; Female; Hippocampus; Learning; Memory Disorders; MicroRNAs; Pregnancy; Rats; Se | 2023 |
SAHA Improves Depressive Symptoms, Cognitive Impairment and Oxidative Stress: Rise of a New Antidepressant Class.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Cognitive Dysfunction; Depression; Female; Fluoxet | 2021 |
Histone deacetylase inhibitor M344 significantly improves nuclear reprogramming, blastocyst quality, and in vitro developmental capacity of cloned pig embryos.
Topics: Acetylation; Animals; Blastocyst; Cellular Reprogramming; Embryo, Mammalian; Embryonic Development; | 2017 |
Propofol exposure during early gestation impairs learning and memory in rat offspring by inhibiting the acetylation of histone.
Topics: Acetylation; Anesthesia; Animals; Cyclic AMP Response Element-Binding Protein; Down-Regulation; Drug | 2018 |
Pharmacological rescue of nociceptive hypersensitivity and oxytocin analgesia impairment in a rat model of neonatal maternal separation.
Topics: Action Potentials; Analgesics; Animals; Animals, Newborn; Antidiuretic Hormone Receptor Antagonists; | 2018 |
Suberoylanilide hydroxamic acid (SAHA) alleviates the learning and memory impairment in rat offspring caused by maternal sevoflurane exposure during late gestation.
Topics: Anesthetics, Inhalation; Animals; Cyclic AMP Response Element-Binding Protein; Female; Hippocampus; | 2019 |
Pentyl-4-yn-VPA, a histone deacetylase inhibitor, ameliorates deficits in social behavior and cognition in a rodent model of autism spectrum disorders.
Topics: Acetylation; Animals; Behavior, Animal; Cerebellar Cortex; Child Development Disorders, Pervasive; C | 2014 |
Altering histone acetylation status in donor cells with suberoylanilide hydroxamic acid does not affect dog cloning efficiency.
Topics: Acetylation; Animals; Apoptosis; Cellular Reprogramming; Cloning, Organism; Dogs; Dose-Response Rela | 2015 |
The effect of histone deacetylase inhibition on the expression of P-glycoprotein in human placental trophoblast cell lines.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line; Female; Histone Deacetylase Inhi | 2017 |
Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, protects dopaminergic neurons from neurotoxin-induced damage.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Animals, Newborn; Astrocytes; Cell Survival; Cells, Cultured; | 2012 |
Assessment of developmental toxicity of vorinostat, a histone deacetylase inhibitor, in Sprague-Dawley rats and Dutch Belted rabbits.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Dose-Response Relationship, Drug; Enzyme Inhibito | 2007 |
Comment on developmental toxicity evaluation on Vorinostat and relationship with HDAC inhibition.
Topics: Abnormalities, Drug-Induced; Animals; Bone Development; Enzyme Inhibitors; Female; Fetal Development | 2007 |