vorinostat has been researched along with Niemann-Pick Disease, Type C in 6 studies
Vorinostat: A hydroxamic acid and anilide derivative that acts as a HISTONE DEACETYLASE inhibitor. It is used in the treatment of CUTANEOUS T-CELL LYMPHOMA and SEZARY SYNDROME.
vorinostat : A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).
Niemann-Pick Disease, Type C: An autosomal recessive lipid storage disorder that is characterized by accumulation of CHOLESTEROL and SPHINGOMYELINS in cells of the VISCERA and the CENTRAL NERVOUS SYSTEM. Type C (or C1) and type D are allelic disorders caused by mutation of the NPC1 gene, which encodes a protein that mediates intracellular cholesterol transport from LYSOSOMES. Clinical signs include hepatosplenomegaly and chronic neurological symptoms. Type D is a variant in people with a Nova Scotia ancestry.
| Excerpt | Relevance | Reference |
|---|
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Granatosky, EA | 1 |
| DiPrimio, N | 1 |
| Pickering, JRE | 1 |
| Stevens, DC | 1 |
| Perlstein, EO | 1 |
| Taylor, RE | 1 |
| Wang, C | 1 |
| Scott, SM | 2 |
| Subramanian, K | 3 |
| Loguercio, S | 1 |
| Zhao, P | 1 |
| Hutt, DM | 2 |
| Farhat, NY | 1 |
| Porter, FD | 2 |
| Balch, WE | 2 |
| Davidson, J | 1 |
| Molitor, E | 1 |
| Moores, S | 1 |
| Gale, SE | 1 |
| Jiang, X | 1 |
| Sidhu, R | 1 |
| Kell, P | 1 |
| Zhang, J | 1 |
| Fujiwara, H | 1 |
| Davidson, C | 1 |
| Helquist, P | 2 |
| Melancon, BJ | 1 |
| Grigalunas, M | 1 |
| Liu, G | 1 |
| Salahi, F | 1 |
| Wiest, O | 2 |
| Xu, X | 1 |
| Pipalia, NH | 2 |
| Cruz, DL | 1 |
| Holson, EB | 1 |
| Schaffer, JE | 1 |
| Walkley, SU | 1 |
| Maxfield, FR | 2 |
| Ory, DS | 1 |
| Alam, MS | 1 |
| Getz, M | 1 |
| Haldar, K | 1 |
| Mao, S | 1 |
| Ralph, H | 1 |
| Wehrmann, ZT | 1 |
| Hulett, TW | 1 |
| Huegel, KL | 1 |
| Vaughan, KT | 1 |
| Goodson, H | 1 |
6 other studies available for vorinostat and Niemann-Pick Disease, Type C
| Article | Year |
|---|---|
GEX1A, a Polyketide from Streptomyces chromofuscus, Corrects the Cellular Defects Associated with Niemann-Pick Type C1 in Human Fibroblasts.
Topics: Cell Line; Cholesterol; Fatty Alcohols; Fibroblasts; Humans; Molecular Structure; Niemann-Pick Disea | 2018 |
Quantitating the epigenetic transformation contributing to cholesterol homeostasis using Gaussian process.
Topics: Cell Line, Tumor; Cholesterol; Endosomes; Epigenesis, Genetic; Epigenomics; Fibroblasts; HeLa Cells; | 2019 |
2-Hydroxypropyl-β-cyclodextrin is the active component in a triple combination formulation for treatment of Niemann-Pick C1 disease.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Animals; Cells, Cultured; Drug Combinations; Histone Deacetylase | 2019 |
Chronic administration of an HDAC inhibitor treats both neurological and systemic Niemann-Pick type C disease in a mouse model.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Animals; beta-Cyclodextrins; Blood-Brain Barrier; Disease Models, | 2016 |
Histone deacetylase inhibitors correct the cholesterol storage defect in most Niemann-Pick C1 mutant cells.
Topics: Carrier Proteins; Cell Line; Cholesterol; Endoplasmic Reticulum-Associated Degradation; Endosomes; F | 2017 |
Quantitative comparison of the efficacy of various compounds in lowering intracellular cholesterol levels in Niemann-Pick type C fibroblasts.
Topics: Azacitidine; beta-Cyclodextrins; Cells, Cultured; Child; Child, Preschool; Chloroquine; Chlorpromazi | 2012 |