vorinostat has been researched along with Mitochondrial Diseases in 1 studies
Vorinostat: A hydroxamic acid and anilide derivative that acts as a HISTONE DEACETYLASE inhibitor. It is used in the treatment of CUTANEOUS T-CELL LYMPHOMA and SEZARY SYNDROME.
vorinostat : A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).
Mitochondrial Diseases: Diseases caused by abnormal function of the MITOCHONDRIA. They may be caused by mutations, acquired or inherited, in mitochondrial DNA or in nuclear genes that code for mitochondrial components. They may also be the result of acquired mitochondria dysfunction due to adverse effects of drugs, infections, or other environmental causes.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Recent reports linking HDAC6 to mitochondrial turnover and neurodegeneration led us to hypothesize that an inhibitor such as Vorinostat (suberoylanilide hydroxamic acid, SAHA) may reduce mitochondrial damage found in retinitis pigmentosa (RP), a progressive neurodegenerative disease of the eye." | 4.02 | SAHA is neuroprotective in in vitro and in situ models of retinitis pigmentosa. ( Bandyopadhyay, M; Beeson, CC; Nasarre, C; Perron, NR; Rohrer, B, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| Perron, NR | 1 |
| Nasarre, C | 1 |
| Bandyopadhyay, M | 1 |
| Beeson, CC | 1 |
| Rohrer, B | 1 |
1 other study available for vorinostat and Mitochondrial Diseases
| Article | Year |
|---|---|
SAHA is neuroprotective in in vitro and in situ models of retinitis pigmentosa.
Topics: Animals; Blotting, Western; Cell Line; Cell Survival; Disease Models, Animal; Histone Deacetylase In | 2021 |