vorinostat has been researched along with Lupus Erythematosus, Systemic in 3 studies
Vorinostat: A hydroxamic acid and anilide derivative that acts as a HISTONE DEACETYLASE inhibitor. It is used in the treatment of CUTANEOUS T-CELL LYMPHOMA and SEZARY SYNDROME.
vorinostat : A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).
Lupus Erythematosus, Systemic: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Studies in human systemic lupus erythematosus (SLE) suggest a possible role for histone deacetylases (HDACs) in skewed gene expression and disease pathogenesis." | 1.32 | Histone deacetylase inhibitors modulate renal disease in the MRL-lpr/lpr mouse. ( Brown, DR; Gilkeson, GS; Mishra, N; Reilly, CM; Ruiz, P, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mishra, N | 2 |
| Reilly, CM | 2 |
| Brown, DR | 1 |
| Ruiz, P | 2 |
| Gilkeson, GS | 2 |
| Foubister, V | 1 |
| Miller, JM | 1 |
| Joshi, D | 1 |
| Richon, VM | 1 |
| Marks, PA | 1 |
3 other studies available for vorinostat and Lupus Erythematosus, Systemic
| Article | Year |
|---|---|
Histone deacetylase inhibitors modulate renal disease in the MRL-lpr/lpr mouse.
Topics: Animals; Autoantibodies; Down-Regulation; Enzyme Inhibitors; Female; Histone Deacetylase Inhibitors; | 2003 |
Anticancer drug shows promise against lupus.
Topics: Animals; Antineoplastic Agents; Clinical Trials as Topic; Histone Deacetylase Inhibitors; Humans; Hy | 2003 |
Modulation of renal disease in MRL/lpr mice by suberoylanilide hydroxamic acid.
Topics: Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Autoantibodies; CD3 Comple | 2004 |