vorinostat has been researched along with Intellectual Disability in 2 studies
Vorinostat: A hydroxamic acid and anilide derivative that acts as a HISTONE DEACETYLASE inhibitor. It is used in the treatment of CUTANEOUS T-CELL LYMPHOMA and SEZARY SYNDROME.
vorinostat : A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).
Intellectual Disability: Subnormal intellectual functioning which originates during the developmental period. This has multiple potential etiologies, including genetic defects and perinatal insults. Intelligence quotient (IQ) scores are commonly used to determine whether an individual has an intellectual disability. IQ scores between 70 and 79 are in the borderline range. Scores below 67 are in the disabled range. (from Joynt, Clinical Neurology, 1992, Ch55, p28)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Autism spectrum disorder (ASD) and intellectual disability (ID) are neurodevelopmental diseases associated with various gene mutations." | 1.62 | Vorinostat, a histone deacetylase inhibitor, ameliorates the sociability and cognitive memory in an Ash1L-deletion-induced ASD/ID mouse model. ( Aljazi, MB; Gao, Y; He, J; Wu, Y, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gao, Y | 1 |
| Aljazi, MB | 1 |
| Wu, Y | 1 |
| He, J | 1 |
| Kennedy, AJ | 1 |
| Rahn, EJ | 1 |
| Paulukaitis, BS | 1 |
| Savell, KE | 1 |
| Kordasiewicz, HB | 1 |
| Wang, J | 1 |
| Lewis, JW | 1 |
| Posey, J | 1 |
| Strange, SK | 1 |
| Guzman-Karlsson, MC | 1 |
| Phillips, SE | 1 |
| Decker, K | 1 |
| Motley, ST | 1 |
| Swayze, EE | 1 |
| Ecker, DJ | 1 |
| Michael, TP | 1 |
| Day, JJ | 1 |
| Sweatt, JD | 1 |
2 other studies available for vorinostat and Intellectual Disability
| Article | Year |
|---|---|
Vorinostat, a histone deacetylase inhibitor, ameliorates the sociability and cognitive memory in an Ash1L-deletion-induced ASD/ID mouse model.
Topics: Animals; Autism Spectrum Disorder; Cognitive Dysfunction; Disease Models, Animal; DNA-Binding Protei | 2021 |
Tcf4 Regulates Synaptic Plasticity, DNA Methylation, and Memory Function.
Topics: Animals; Autistic Disorder; CpG Islands; Disease Models, Animal; DNA Methylation; Facies; Gene Expre | 2016 |