vorinostat has been researched along with Innate Inflammatory Response in 30 studies
Vorinostat: A hydroxamic acid and anilide derivative that acts as a HISTONE DEACETYLASE inhibitor. It is used in the treatment of CUTANEOUS T-CELL LYMPHOMA and SEZARY SYNDROME.
vorinostat : A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).
| Excerpt | Relevance | Reference |
|---|---|---|
| " At the end of dosing schedule, neurobehavioral tests were conducted; followed by mechanistic evaluation through biochemical analysis, RTPCR and western blot in serum and hippocampus." | 5.48 | Antidepressant activity of vorinostat is associated with amelioration of oxidative stress and inflammation in a corticosterone-induced chronic stress model in mice. ( Js, IC; Kv, A; Lahkar, M; Madhana, RM; Naidu, VGM; Sinha, S, 2018) |
| "We examined immunological responses in patients receiving histone deacetylase (HDAC) inhibition (vorinostat) for graft-versus-host disease prophylaxis after allogeneic hematopoietic cell transplant." | 5.20 | Histone deacetylase inhibition regulates inflammation and enhances Tregs after allogeneic hematopoietic cell transplantation in humans. ( Choi, SW; Dinarello, CA; Gatza, E; Hou, G; Oravecz-Wilson, K; Reddy, P; Song, Y; Sun, Y; Tawara, I; Whitfield, J, 2015) |
| " Here we explored the impact of the histone deacetylase (HDAC) inhibitor suberoylanilide hydroxamic acid (SAHA) on somatic hyperalgesia induced by stress or stress combined with orofacial inflammation, which mimicked the comorbidity of FMS and TMD in rats." | 1.72 | SAHA Inhibits Somatic Hyperalgesia Induced by Stress Combined with Orofacial Inflammation Through Targeting Different Spinal 5-HT Receptor Subtypes. ( Bai, G; Cao, DY; Li, JF; Qiu, XY; Tao, ZY; Wei, SQ, 2022) |
| " At the end of dosing schedule, neurobehavioral tests were conducted; followed by mechanistic evaluation through biochemical analysis, RTPCR and western blot in serum and hippocampus." | 1.48 | Antidepressant activity of vorinostat is associated with amelioration of oxidative stress and inflammation in a corticosterone-induced chronic stress model in mice. ( Js, IC; Kv, A; Lahkar, M; Madhana, RM; Naidu, VGM; Sinha, S, 2018) |
| "Vorinostat treatment increased the frequency of functional regulatory T-cell subsets and their transcription factors Gata3 and FoxP3 in parallel to a decrease in inflammatory dendritic cell subsets and their cytokines IL-6, IL-12, and TNF-α." | 1.40 | Lysine deacetylase inhibition prevents diabetes by chromatin-independent immunoregulation and β-cell protection. ( Aikin, RA; Billestrup, N; Birkbak, N; Blaabjerg, L; Christensen, DP; Dahllöf, MS; Dinarello, CA; Fossati, G; Grunnet, LG; Gysemans, C; Lundh, M; Mandrup, S; Mandrup-Poulsen, T; Mascagni, P; Mathieu, C; Monzani, V; Noesgaard, D; Paraskevas, S; Piemonti, L; Schmidt, SF; Workman, CT, 2014) |
| "Inflammatory breast cancer (IBC) is the most aggressive form of locally advanced breast cancer (LABC)." | 1.36 | Suberoylanilide hydroxamic acid blocks self-renewal and homotypic aggregation of inflammatory breast cancer spheroids. ( Bornmann, W; Cristofanilli, M; Hall, CS; Pal, A; Peng, Z; Pickei, R; Robertson, FM; Woodward, WA; Ye, Z, 2010) |
| "MMR-deficient colorectal cancers are classically characterized by right-sided location, multifocality, mucinous histology, and lymphocytic infiltration." | 1.35 | Epigenetic repression of DNA mismatch repair by inflammation and hypoxia in inflammatory bowel disease-associated colorectal cancer. ( Afrasiabi, K; Birnbaumer, L; Edwards, RA; Lipkin, SM; Pham, T; Wang, K; Witherspoon, M, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (16.67) | 29.6817 |
| 2010's | 18 (60.00) | 24.3611 |
| 2020's | 7 (23.33) | 2.80 |
| Authors | Studies |
|---|---|
| Saunders, MJ | 1 |
| Edwards, BS | 1 |
| Zhu, J | 1 |
| Sklar, LA | 1 |
| Graves, SW | 1 |
| Tong, J | 1 |
| Zhou, J | 1 |
| Fang, M | 1 |
| Wang, G | 1 |
| Fu, S | 1 |
| Sun, B | 1 |
| Lv, J | 1 |
| Tao, ZY | 1 |
| Qiu, XY | 1 |
| Wei, SQ | 1 |
| Bai, G | 1 |
| Li, JF | 1 |
| Cao, DY | 1 |
| Chou, PJ | 1 |
| Sarwar, MS | 1 |
| Wang, L | 2 |
| Wu, R | 1 |
| Li, S | 1 |
| Hudlikar, RR | 1 |
| Wang, Y | 2 |
| Su, X | 1 |
| Kong, AN | 1 |
| Wetzel, A | 1 |
| Scholtka, B | 1 |
| Gerecke, C | 1 |
| Kleuser, B | 1 |
| Zierfuss, B | 1 |
| Weinhofer, I | 1 |
| Kühl, JS | 1 |
| Köhler, W | 1 |
| Bley, A | 1 |
| Zauner, K | 1 |
| Binder, J | 1 |
| Martinović, K | 1 |
| Seiser, C | 1 |
| Hertzberg, C | 1 |
| Kemp, S | 1 |
| Egger, G | 1 |
| Leitner, G | 1 |
| Bauer, J | 1 |
| Wiesinger, C | 1 |
| Kunze, M | 1 |
| Forss-Petter, S | 1 |
| Berger, J | 1 |
| Weiss, U | 1 |
| Möller, M | 1 |
| Husseini, SA | 1 |
| Manderscheid, C | 1 |
| Häusler, J | 1 |
| Geisslinger, G | 1 |
| Niederberger, E | 1 |
| Takada, N | 1 |
| Nakamura, Y | 1 |
| Ikeda, K | 1 |
| Takaoka, N | 1 |
| Hisaoka-Nakashima, K | 1 |
| Sanoh, S | 1 |
| Kotake, Y | 1 |
| Nakata, Y | 1 |
| Morioka, N | 1 |
| Li, T | 1 |
| Zhang, YM | 1 |
| Han, D | 1 |
| Hua, R | 1 |
| Guo, BN | 1 |
| Hu, SQ | 1 |
| Yan, XL | 1 |
| Xu, T | 1 |
| Kv, A | 1 |
| Madhana, RM | 1 |
| Js, IC | 1 |
| Lahkar, M | 1 |
| Sinha, S | 1 |
| Naidu, VGM | 1 |
| Cao, F | 1 |
| Zwinderman, MRH | 1 |
| Dekker, FJ | 1 |
| Ratay, ML | 1 |
| Balmert, SC | 1 |
| Bassin, EJ | 1 |
| Little, SR | 1 |
| Choi, G | 1 |
| Yang, TJ | 1 |
| Yoo, S | 1 |
| Choi, SI | 1 |
| Lim, JY | 1 |
| Cho, PS | 1 |
| Hwang, SW | 1 |
| Christensen, DP | 1 |
| Gysemans, C | 1 |
| Lundh, M | 1 |
| Dahllöf, MS | 1 |
| Noesgaard, D | 1 |
| Schmidt, SF | 1 |
| Mandrup, S | 1 |
| Birkbak, N | 1 |
| Workman, CT | 1 |
| Piemonti, L | 1 |
| Blaabjerg, L | 1 |
| Monzani, V | 1 |
| Fossati, G | 1 |
| Mascagni, P | 2 |
| Paraskevas, S | 1 |
| Aikin, RA | 1 |
| Billestrup, N | 1 |
| Grunnet, LG | 1 |
| Dinarello, CA | 2 |
| Mathieu, C | 1 |
| Mandrup-Poulsen, T | 1 |
| Zhou, H | 1 |
| Jiang, S | 1 |
| Chen, J | 1 |
| Su, SB | 1 |
| Choi, SW | 1 |
| Gatza, E | 1 |
| Hou, G | 1 |
| Sun, Y | 1 |
| Whitfield, J | 1 |
| Song, Y | 1 |
| Oravecz-Wilson, K | 1 |
| Tawara, I | 1 |
| Reddy, P | 1 |
| Litvinov, IV | 1 |
| Cordeiro, B | 1 |
| Fredholm, S | 1 |
| Ødum, N | 1 |
| Zargham, H | 1 |
| Huang, Y | 1 |
| Zhou, Y | 1 |
| Pehr, K | 1 |
| Kupper, TS | 1 |
| Woetmann, A | 1 |
| Sasseville, D | 1 |
| Tao, W | 1 |
| Chen, Q | 1 |
| Zhou, W | 1 |
| Zhang, Z | 1 |
| Cao, M | 1 |
| Royce, DB | 1 |
| Risingsong, R | 1 |
| Williams, CR | 1 |
| Sporn, MB | 1 |
| Liby, KT | 1 |
| Alam, MS | 1 |
| Getz, M | 1 |
| Haldar, K | 1 |
| Feng, Q | 1 |
| Su, Z | 1 |
| Song, S | 1 |
| Χu, H | 1 |
| Zhang, B | 1 |
| Yi, L | 1 |
| Tian, M | 1 |
| Wang, H | 1 |
| Sailhamer, EA | 1 |
| Li, Y | 1 |
| Smith, EJ | 1 |
| Shuja, F | 1 |
| Shults, C | 1 |
| Liu, B | 1 |
| Soupir, C | 1 |
| deMoya, M | 1 |
| Velmahos, G | 1 |
| Alam, HB | 1 |
| Chiechio, S | 1 |
| Zammataro, M | 1 |
| Morales, ME | 1 |
| Busceti, CL | 1 |
| Drago, F | 1 |
| Gereau, RW | 1 |
| Copani, A | 1 |
| Nicoletti, F | 1 |
| Edwards, RA | 1 |
| Witherspoon, M | 1 |
| Wang, K | 1 |
| Afrasiabi, K | 1 |
| Pham, T | 1 |
| Birnbaumer, L | 1 |
| Lipkin, SM | 1 |
| Halili, MA | 1 |
| Andrews, MR | 1 |
| Labzin, LI | 1 |
| Schroder, K | 1 |
| Matthias, G | 1 |
| Cao, C | 1 |
| Lovelace, E | 1 |
| Reid, RC | 1 |
| Le, GT | 1 |
| Hume, DA | 1 |
| Irvine, KM | 1 |
| Matthias, P | 1 |
| Fairlie, DP | 1 |
| Sweet, MJ | 1 |
| Robertson, FM | 1 |
| Woodward, WA | 1 |
| Pickei, R | 1 |
| Ye, Z | 1 |
| Bornmann, W | 1 |
| Pal, A | 1 |
| Peng, Z | 1 |
| Hall, CS | 1 |
| Cristofanilli, M | 1 |
| Singh, J | 1 |
| Khan, M | 1 |
| Singh, I | 1 |
| Li, X | 1 |
| Zhou, Q | 1 |
| Hanus, J | 1 |
| Anderson, C | 1 |
| Zhang, H | 1 |
| Dellinger, M | 1 |
| Brekken, R | 1 |
| Wang, S | 1 |
| Klampfer, L | 1 |
| Huang, J | 1 |
| Swaby, LA | 1 |
| Augenlicht, L | 1 |
| Leng, C | 1 |
| Gries, M | 1 |
| Ziegler, J | 1 |
| Lokshin, A | 1 |
| Lentzsch, S | 1 |
| Mapara, MY | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| An Open-Label, Proof of Concept Study of Vorinostat for the Treatment of Moderate-to-Severe Crohn's Disease and Maintenance Therapy With Ustekinumab[NCT03167437] | Phase 1/Phase 2 | 35 participants (Anticipated) | Interventional | 2017-10-30 | Recruiting | ||
| A Phase I/II Study of Romidepsin in Combination With Abraxane in Patients With Metastatic Inflammatory Breast Cancer[NCT01938833] | Phase 1/Phase 2 | 9 participants (Actual) | Interventional | 2014-04-30 | Terminated (stopped due to Closed by Sponsor) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for vorinostat and Innate Inflammatory Response
| Article | Year |
|---|---|
The Process and Strategy for Developing Selective Histone Deacetylase 3 Inhibitors.
Topics: Antineoplastic Agents; Chemistry Techniques, Synthetic; Depsipeptides; Drug Design; Epigenesis, Gene | 2018 |
1 trial available for vorinostat and Innate Inflammatory Response
| Article | Year |
|---|---|
Histone deacetylase inhibition regulates inflammation and enhances Tregs after allogeneic hematopoietic cell transplantation in humans.
Topics: Acetylation; Adult; Aged; Cytokines; Female; Forkhead Transcription Factors; Gene Expression Regulat | 2015 |
28 other studies available for vorinostat and Innate Inflammatory Response
| Article | Year |
|---|---|
Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
Topics: Animals; Biotinylation; Flow Cytometry; Fluorescence Resonance Energy Transfer; Green Fluorescent Pr | 2010 |
The anti-inflammatory mechanism of SAHA in acute pancreatitis through HDAC5/SLIT2/Akt/β-catenin axis.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; beta Catenin; Histone Deacetylases; Inflammation; | 2022 |
SAHA Inhibits Somatic Hyperalgesia Induced by Stress Combined with Orofacial Inflammation Through Targeting Different Spinal 5-HT Receptor Subtypes.
Topics: Animals; Epigenesis, Genetic; Female; Hyperalgesia; Inflammation; Rats; Rats, Sprague-Dawley; Recept | 2022 |
Metabolomic, DNA Methylomic, and Transcriptomic Profiling of Suberoylanilide Hydroxamic Acid Effects on LPS-Exposed Lung Epithelial Cells.
Topics: DNA; Epithelial Cells; Glutathione; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Inflam | 2023 |
Epigenetic histone modulation contributes to improvements in inflammatory bowel disease via EBI3.
Topics: Animals; Caspase 3; CD3 Complex; Colitis; Dextran Sulfate; Epigenesis, Genetic; Histone Deacetylase | 2020 |
Vorinostat in the acute neuroinflammatory form of X-linked adrenoleukodystrophy.
Topics: Acute Disease; Adrenoleukodystrophy; ATP Binding Cassette Transporter, Subfamily D; ATP Binding Cass | 2020 |
Inhibition of HDAC Enzymes Contributes to Differential Expression of Pro-Inflammatory Proteins in the TLR-4 Signaling Cascade.
Topics: Animals; Cyclooxygenase 2; Gene Expression Regulation; Histone Deacetylase Inhibitors; Histone Deace | 2020 |
Treatment with Histone Deacetylase Inhibitor Attenuates Peripheral Inflammation-Induced Cognitive Dysfunction and Microglial Activation: The Effect of SAHA as a Peripheral HDAC Inhibitor.
Topics: Animals; Cognitive Dysfunction; Cytokines; Hippocampus; Histone Deacetylase Inhibitors; Inflammation | 2021 |
Involvement of IL-17 in Secondary Brain Injury After a Traumatic Brain Injury in Rats.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Brain Damage, Chronic; Brain Injuries, Traumatic; | 2017 |
Antidepressant activity of vorinostat is associated with amelioration of oxidative stress and inflammation in a corticosterone-induced chronic stress model in mice.
Topics: Animals; Anti-Inflammatory Agents; Antidepressive Agents; Antioxidants; Anxiety; Chronic Disease; Co | 2018 |
Controlled release of an HDAC inhibitor for reduction of inflammation in dry eye disease.
Topics: Animals; Cell Proliferation; Delayed-Action Preparations; Dry Eye Syndromes; Female; Histone Deacety | 2018 |
TRPV4-Mediated Anti-nociceptive Effect of Suberanilohydroxamic Acid on Mechanical Pain.
Topics: Analgesics; Animals; Behavior, Animal; Cells, Cultured; HEK293 Cells; Humans; Inflammation; Male; Mi | 2019 |
Lysine deacetylase inhibition prevents diabetes by chromatin-independent immunoregulation and β-cell protection.
Topics: Animals; Cell Line; Chromatin; Cytokines; Diabetes Mellitus, Type 1; Disease Models, Animal; Epigene | 2014 |
Suberoylanilide hydroxamic acid suppresses inflammation-induced neovascularization.
Topics: ADAM Proteins; ADAMTS1 Protein; Administration, Ophthalmic; Animals; Apoptosis; Basic Helix-Loop-Hel | 2014 |
Analysis of STAT4 expression in cutaneous T-cell lymphoma (CTCL) patients and patient-derived cell lines.
Topics: Cell Line, Tumor; Depsipeptides; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; | 2014 |
Brainstem brain-derived neurotrophic factor signaling is required for histone deacetylase inhibitor-induced pain relief.
Topics: Analgesics; Animals; Brain-Derived Neurotrophic Factor; Carbazoles; gamma-Aminobutyric Acid; Glutama | 2015 |
The Rexinoids LG100268 and LG101506 Inhibit Inflammation and Suppress Lung Carcinogenesis in A/J Mice.
Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents; Carboplatin; Carcinogenesis; Cell Line; Che | 2016 |
Chronic administration of an HDAC inhibitor treats both neurological and systemic Niemann-Pick type C disease in a mouse model.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Animals; beta-Cyclodextrins; Blood-Brain Barrier; Disease Models, | 2016 |
Histone deacetylase inhibitors suppress RSV infection and alleviate virus-induced airway inflammation.
Topics: Animals; Blotting, Western; Bronchi; Cell Line; Cell Line, Tumor; Cyclooxygenase 2; Cytokines; Epith | 2016 |
Acetylation: a novel method for modulation of the immune response following trauma/hemorrhage and inflammatory second hit in animals and humans.
Topics: Abdominal Injuries; Acetylation; Adult; Animals; Cell Culture Techniques; Female; Hemorrhage; Histon | 2008 |
Epigenetic modulation of mGlu2 receptors by histone deacetylase inhibitors in the treatment of inflammatory pain.
Topics: Amino Acids; Animals; Benzamides; Bridged Bicyclo Compounds, Heterocyclic; Enzyme Inhibitors; Epigen | 2009 |
Epigenetic repression of DNA mismatch repair by inflammation and hypoxia in inflammatory bowel disease-associated colorectal cancer.
Topics: Adaptor Proteins, Signal Transducing; Adenoma; Adenosine Triphosphatases; Animals; Cell Hypoxia; Col | 2009 |
Differential effects of selective HDAC inhibitors on macrophage inflammatory responses to the Toll-like receptor 4 agonist LPS.
Topics: Animals; Blotting, Western; Chromatin Immunoprecipitation; Cyclooxygenase 2; Enzyme-Linked Immunosor | 2010 |
Suberoylanilide hydroxamic acid blocks self-renewal and homotypic aggregation of inflammatory breast cancer spheroids.
Topics: Antineoplastic Agents; Breast Neoplasms; Cadherins; Cell Aggregation; Cell Division; Cell Line, Tumo | 2010 |
HDAC inhibitor SAHA normalizes the levels of VLCFAs in human skin fibroblasts from X-ALD patients and downregulates the expression of proinflammatory cytokines in Abcd1/2-silenced mouse astrocytes.
Topics: Acetylation; Acetyltransferases; Adrenoleukodystrophy; Animals; Astrocytes; ATP Binding Cassette Tra | 2011 |
Inhibition of multiple pathogenic pathways by histone deacetylase inhibitor SAHA in a corneal alkali-burn injury model.
Topics: Alkalies; Animals; Burns, Chemical; Cornea; Corneal Diseases; Corneal Injuries; Corneal Neovasculari | 2013 |
Requirement of histone deacetylase activity for signaling by STAT1.
Topics: Active Transport, Cell Nucleus; Apoptosis; bcl-X Protein; Blotting, Western; Butyrates; Cell Line; C | 2004 |
Reduction of graft-versus-host disease by histone deacetylase inhibitor suberonylanilide hydroxamic acid is associated with modulation of inflammatory cytokine milieu and involves inhibition of STAT1.
Topics: Animals; Bone Marrow Transplantation; Cell Proliferation; Cytokines; Enzyme Inhibitors; Female; Graf | 2006 |