vorinostat and Hypertension, Pulmonary
vorinostat has been researched along with Hypertension, Pulmonary in 2 studies
Vorinostat: A hydroxamic acid and anilide derivative that acts as a HISTONE DEACETYLASE inhibitor. It is used in the treatment of CUTANEOUS T-CELL LYMPHOMA and SEZARY SYNDROME.
vorinostat : A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).
Hypertension, Pulmonary: Increased VASCULAR RESISTANCE in the PULMONARY CIRCULATION, usually secondary to HEART DISEASES or LUNG DISEASES.
Research Excerpts
Excerpt | Relevance | Reference |
---|---|---|
" Both valproic acid, a class I HDAC inhibitor, and suberoylanilide hydroxamic acid (vorinostat), an inhibitor of class I, II, and IV HDACs, mitigated the development of and reduced established hypoxia-induced pulmonary hypertension in the rat." | 7.78 | Histone deacetylation inhibition in pulmonary hypertension: therapeutic potential of valproic acid and suberoylanilide hydroxamic acid. ( Chen, CN; Cotroneo, E; Hajji, N; Li, M; McKinsey, TA; Oliver, E; Stenmark, KR; Wang, D; Wharton, J; Wilkins, MR; Zhao, L, 2012) |
" Both valproic acid, a class I HDAC inhibitor, and suberoylanilide hydroxamic acid (vorinostat), an inhibitor of class I, II, and IV HDACs, mitigated the development of and reduced established hypoxia-induced pulmonary hypertension in the rat." | 3.78 | Histone deacetylation inhibition in pulmonary hypertension: therapeutic potential of valproic acid and suberoylanilide hydroxamic acid. ( Chen, CN; Cotroneo, E; Hajji, N; Li, M; McKinsey, TA; Oliver, E; Stenmark, KR; Wang, D; Wharton, J; Wilkins, MR; Zhao, L, 2012) |
Research
Studies (2)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 1 (50.00) | 24.3611 |
2020's | 1 (50.00) | 2.80 |
Authors
Authors | Studies |
---|---|
Chelladurai, P | 1 |
Dabral, S | 1 |
Basineni, SR | 1 |
Chen, CN | 2 |
Schmoranzer, M | 1 |
Bender, N | 1 |
Feld, C | 1 |
Nötzold, RR | 1 |
Dobreva, G | 1 |
Wilhelm, J | 1 |
Jungblut, B | 1 |
Zhao, L | 2 |
Bauer, UM | 1 |
Seeger, W | 1 |
Pullamsetti, SS | 1 |
Hajji, N | 1 |
Oliver, E | 1 |
Cotroneo, E | 1 |
Wharton, J | 1 |
Wang, D | 1 |
Li, M | 1 |
McKinsey, TA | 1 |
Stenmark, KR | 1 |
Wilkins, MR | 1 |
Other Studies
2 other studies available for vorinostat and Hypertension, Pulmonary
Article | Year |
---|---|
Isoform-specific characterization of class I histone deacetylases and their therapeutic modulation in pulmonary hypertension.
Topics: Animals; Cells, Cultured; Depsipeptides; Histone Deacetylases; Humans; Hypertension, Pulmonary; In V | 2020 |
Histone deacetylation inhibition in pulmonary hypertension: therapeutic potential of valproic acid and suberoylanilide hydroxamic acid.
Topics: Animals; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Histone Deacetylase 1; Histone | 2012 |