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vorinostat and Hypertension, Pulmonary

vorinostat has been researched along with Hypertension, Pulmonary in 2 studies

Vorinostat: A hydroxamic acid and anilide derivative that acts as a HISTONE DEACETYLASE inhibitor. It is used in the treatment of CUTANEOUS T-CELL LYMPHOMA and SEZARY SYNDROME.
vorinostat : A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).

Hypertension, Pulmonary: Increased VASCULAR RESISTANCE in the PULMONARY CIRCULATION, usually secondary to HEART DISEASES or LUNG DISEASES.

Research Excerpts

ExcerptRelevanceReference
" Both valproic acid, a class I HDAC inhibitor, and suberoylanilide hydroxamic acid (vorinostat), an inhibitor of class I, II, and IV HDACs, mitigated the development of and reduced established hypoxia-induced pulmonary hypertension in the rat."7.78Histone deacetylation inhibition in pulmonary hypertension: therapeutic potential of valproic acid and suberoylanilide hydroxamic acid. ( Chen, CN; Cotroneo, E; Hajji, N; Li, M; McKinsey, TA; Oliver, E; Stenmark, KR; Wang, D; Wharton, J; Wilkins, MR; Zhao, L, 2012)
" Both valproic acid, a class I HDAC inhibitor, and suberoylanilide hydroxamic acid (vorinostat), an inhibitor of class I, II, and IV HDACs, mitigated the development of and reduced established hypoxia-induced pulmonary hypertension in the rat."3.78Histone deacetylation inhibition in pulmonary hypertension: therapeutic potential of valproic acid and suberoylanilide hydroxamic acid. ( Chen, CN; Cotroneo, E; Hajji, N; Li, M; McKinsey, TA; Oliver, E; Stenmark, KR; Wang, D; Wharton, J; Wilkins, MR; Zhao, L, 2012)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (50.00)24.3611
2020's1 (50.00)2.80

Authors

AuthorsStudies
Chelladurai, P1
Dabral, S1
Basineni, SR1
Chen, CN2
Schmoranzer, M1
Bender, N1
Feld, C1
Nötzold, RR1
Dobreva, G1
Wilhelm, J1
Jungblut, B1
Zhao, L2
Bauer, UM1
Seeger, W1
Pullamsetti, SS1
Hajji, N1
Oliver, E1
Cotroneo, E1
Wharton, J1
Wang, D1
Li, M1
McKinsey, TA1
Stenmark, KR1
Wilkins, MR1

Other Studies

2 other studies available for vorinostat and Hypertension, Pulmonary

ArticleYear
Isoform-specific characterization of class I histone deacetylases and their therapeutic modulation in pulmonary hypertension.
    Scientific reports, 2020, 07-30, Volume: 10, Issue:1

    Topics: Animals; Cells, Cultured; Depsipeptides; Histone Deacetylases; Humans; Hypertension, Pulmonary; In V

2020
Histone deacetylation inhibition in pulmonary hypertension: therapeutic potential of valproic acid and suberoylanilide hydroxamic acid.
    Circulation, 2012, Jul-24, Volume: 126, Issue:4

    Topics: Animals; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Histone Deacetylase 1; Histone

2012
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