Page last updated: 2024-11-04

vorinostat and Huntington Disease

vorinostat has been researched along with Huntington Disease in 6 studies

Vorinostat: A hydroxamic acid and anilide derivative that acts as a HISTONE DEACETYLASE inhibitor. It is used in the treatment of CUTANEOUS T-CELL LYMPHOMA and SEZARY SYNDROME.
vorinostat : A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).

Huntington Disease: A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4)

Research Excerpts

ExcerptRelevanceReference
"Using Alzheimer's disease and Huntington's disease as examples in the following article, some of latest data linking both the histone code and the various proteins that regulate this code to the pathogenesis of neurological disease are discussed."2.47Epigenetic treatment of neurological disease. ( Gray, SG, 2011)
"We use a Drosophila Huntington's disease model to establish dose regimens and protocols to assess the effectiveness of drug combinations used at low threshold concentrations."1.33Identification of combinatorial drug regimens for treatment of Huntington's disease using Drosophila. ( Agrawal, N; Apostol, BL; Bodai, L; Chang, LW; Chiang, AS; Marsh, JL; Pallos, J; Slepko, N; Thompson, LM, 2005)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (50.00)29.6817
2010's3 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bürli, RW1
Luckhurst, CA1
Aziz, O1
Matthews, KL1
Yates, D1
Lyons, KA1
Beconi, M1
McAllister, G1
Breccia, P1
Stott, AJ1
Penrose, SD1
Wall, M1
Lamers, M1
Leonard, P1
Müller, I1
Richardson, CM1
Jarvis, R1
Stones, L1
Hughes, S1
Wishart, G1
Haughan, AF1
O'Connell, C1
Mead, T1
McNeil, H1
Vann, J1
Mangette, J1
Maillard, M1
Beaumont, V1
Munoz-Sanjuan, I1
Dominguez, C1
Gray, SG1
Mielcarek, M1
Benn, CL1
Franklin, SA1
Smith, DL2
Woodman, B2
Marks, PA2
Bates, GP2
Hockly, E1
Richon, VM1
Zhou, X1
Rosa, E1
Sathasivam, K1
Ghazi-Noori, S1
Mahal, A1
Lowden, PA1
Steffan, JS1
Marsh, JL2
Thompson, LM2
Lewis, CM1
Agrawal, N1
Pallos, J1
Slepko, N1
Apostol, BL1
Bodai, L1
Chang, LW1
Chiang, AS1
Dompierre, JP1
Godin, JD1
Charrin, BC1
Cordelières, FP1
King, SJ1
Humbert, S1
Saudou, F1

Reviews

1 review available for vorinostat and Huntington Disease

ArticleYear
Epigenetic treatment of neurological disease.
    Epigenomics, 2011, Volume: 3, Issue:4

    Topics: Alzheimer Disease; Butylamines; Cell Differentiation; Endoplasmic Reticulum Stress; Epigenesis, Gene

2011

Other Studies

5 other studies available for vorinostat and Huntington Disease

ArticleYear
Design, synthesis, and biological evaluation of potent and selective class IIa histone deacetylase (HDAC) inhibitors as a potential therapy for Huntington's disease.
    Journal of medicinal chemistry, 2013, Dec-27, Volume: 56, Issue:24

    Topics: Animals; Dose-Response Relationship, Drug; Drug Design; Histone Deacetylase Inhibitors; Histone Deac

2013
SAHA decreases HDAC 2 and 4 levels in vivo and improves molecular phenotypes in the R6/2 mouse model of Huntington's disease.
    PloS one, 2011, Volume: 6, Issue:11

    Topics: Animals; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Down-Regulation; Exons; Histone

2011
Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease.
    Proceedings of the National Academy of Sciences of the United States of America, 2003, Feb-18, Volume: 100, Issue:4

    Topics: Acetylation; Animals; Base Sequence; Blood-Brain Barrier; Brain; Disease Models, Animal; DNA Primers

2003
Identification of combinatorial drug regimens for treatment of Huntington's disease using Drosophila.
    Proceedings of the National Academy of Sciences of the United States of America, 2005, Mar-08, Volume: 102, Issue:10

    Topics: Amides; Animals; Benzoquinones; Disease Models, Animal; Drosophila; Drug Therapy, Combination; Femal

2005
Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington's disease by increasing tubulin acetylation.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007, Mar-28, Volume: 27, Issue:13

    Topics: Acetylation; Animals; Biological Transport, Active; Brain-Derived Neurotrophic Factor; Cell Line; Ce

2007