vorinostat has been researched along with Hemorrhagic Shock in 5 studies
Vorinostat: A hydroxamic acid and anilide derivative that acts as a HISTONE DEACETYLASE inhibitor. It is used in the treatment of CUTANEOUS T-CELL LYMPHOMA and SEZARY SYNDROME.
vorinostat : A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mild and severe hemorrhagic shock were induced by total blood volume loss of 20% or 40%, respectively, which was maintained for 60 min." | 1.56 | Suberoylanilide Hydroxamic Acid Alleviates Acute Lung Injury Induced by Severe Hemorrhagic Shock and Resuscitation in Rats. ( Chen, W; Gao, X; He, H; Li, W; Liang, J; Liu, W; Zhou, Y, 2020) |
| "As the primary insult in hemorrhagic shock is cellular hypoxia, and transcription factor hypoxia-inducible factor-1α (HIF-1α) controls proinflammatory gene expression in macrophages, we hypothesized that SAHA would attenuate the HIF-1α associated proinflammatory pathway in a hypoxic macrophage model." | 1.38 | Anti-inflammatory properties of histone deacetylase inhibitors: a mechanistic study. ( Alam, HB; Chen, C; Chong, W; deMoya, MA; King, DR; Kung, AL; Li, Y; Liu, B; Liu, Z; Velmahos, GC; Wonsey, DR; Zhao, T, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, W | 1 |
| Gao, X | 1 |
| Liu, W | 1 |
| Liang, J | 1 |
| Zhou, Y | 1 |
| Chen, W | 1 |
| He, H | 1 |
| Sailhamer, EA | 2 |
| Li, Y | 4 |
| Smith, EJ | 1 |
| Shuja, F | 1 |
| Shults, C | 2 |
| Liu, B | 4 |
| Soupir, C | 1 |
| deMoya, M | 2 |
| Velmahos, G | 1 |
| Alam, HB | 4 |
| Fukudome, EY | 1 |
| Lu, J | 1 |
| Chong, W | 2 |
| Jin, G | 1 |
| Liu, Z | 2 |
| Velmahos, GC | 2 |
| King, DR | 2 |
| Zhao, T | 1 |
| Wonsey, DR | 1 |
| Chen, C | 1 |
| deMoya, MA | 1 |
| Kung, AL | 1 |
| Lin, T | 1 |
| Chen, H | 1 |
| Koustova, E | 1 |
| Rhee, P | 1 |
| Kirkpatrick, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Predictive Value of Nu.Q™ Biomarkers to Help Guiding the Management of Osteoarticular Infections - a Monocentric Prospective Observational Cohort Study[NCT05593874] | 30 participants (Actual) | Observational [Patient Registry] | 2022-10-10 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 other studies available for vorinostat and Hemorrhagic Shock
| Article | Year |
|---|---|
Suberoylanilide Hydroxamic Acid Alleviates Acute Lung Injury Induced by Severe Hemorrhagic Shock and Resuscitation in Rats.
Topics: Acute Lung Injury; Animals; Disease Models, Animal; Lung; Male; NF-kappa B; Rats; Rats, Sprague-Dawl | 2020 |
Acetylation: a novel method for modulation of the immune response following trauma/hemorrhage and inflammatory second hit in animals and humans.
Topics: Abdominal Injuries; Acetylation; Adult; Animals; Cell Culture Techniques; Female; Hemorrhage; Histon | 2008 |
Identification of citrullinated histone H3 as a potential serum protein biomarker in a lethal model of lipopolysaccharide-induced shock.
Topics: Animals; Biomarkers; Blotting, Western; Citrulline; Disease Models, Animal; Histone Deacetylase Inhi | 2011 |
Anti-inflammatory properties of histone deacetylase inhibitors: a mechanistic study.
Topics: Animals; Anti-Inflammatory Agents; Blotting, Western; Cell Hypoxia; Cells, Cultured; Colorimetry; En | 2012 |
Histone deacetylase as therapeutic target in a rodent model of hemorrhagic shock: effect of different resuscitation strategies on lung and liver.
Topics: Acetylation; Animals; Enzyme Inhibitors; Gene Expression; Histone Acetyltransferases; Histone Deacet | 2007 |