vorinostat has been researched along with HbS Disease in 2 studies
Vorinostat: A hydroxamic acid and anilide derivative that acts as a HISTONE DEACETYLASE inhibitor. It is used in the treatment of CUTANEOUS T-CELL LYMPHOMA and SEZARY SYNDROME.
vorinostat : A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The vascular pathobiology of sickle cell anemia involves inflammation, coagulation, vascular stasis, reperfusion injury, iron-based oxidative biochemistry, deficient nitric oxide (NO) bioavailability, and red cell sickling." | 1.36 | The HDAC inhibitors trichostatin A and suberoylanilide hydroxamic acid exhibit multiple modalities of benefit for the vascular pathobiology of sickle transgenic mice. ( Abanonu, CF; Abdulla, F; Belcher, JD; Eaton, JW; Hebbel, RP; Kelm, RJ; Kollander, R; Nguyen, J; Osifuye, S; Pace, BS; Slungaard, A; Solovey, AN; Vercellotti, GM; Vineyard, JV, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Okam, MM | 1 |
| Esrick, EB | 1 |
| Mandell, E | 1 |
| Campigotto, F | 1 |
| Neuberg, DS | 1 |
| Ebert, BL | 1 |
| Hebbel, RP | 1 |
| Vercellotti, GM | 1 |
| Pace, BS | 1 |
| Solovey, AN | 1 |
| Kollander, R | 1 |
| Abanonu, CF | 1 |
| Nguyen, J | 1 |
| Vineyard, JV | 1 |
| Belcher, JD | 1 |
| Abdulla, F | 1 |
| Osifuye, S | 1 |
| Eaton, JW | 1 |
| Kelm, RJ | 1 |
| Slungaard, A | 1 |
1 trial available for vorinostat and HbS Disease
| Article | Year |
|---|---|
Phase 1/2 trial of vorinostat in patients with sickle cell disease who have not benefitted from hydroxyurea.
Topics: Adult; Anemia, Sickle Cell; Antisickling Agents; Female; Histone Deacetylase Inhibitors; Humans; Hyd | 2015 |
1 other study available for vorinostat and HbS Disease
| Article | Year |
|---|---|
The HDAC inhibitors trichostatin A and suberoylanilide hydroxamic acid exhibit multiple modalities of benefit for the vascular pathobiology of sickle transgenic mice.
Topics: Anemia, Sickle Cell; Animals; beta-Thalassemia; Cells, Cultured; Disease Models, Animal; Endothelial | 2010 |