vorinostat has been researched along with Epilepsy in 3 studies
Vorinostat: A hydroxamic acid and anilide derivative that acts as a HISTONE DEACETYLASE inhibitor. It is used in the treatment of CUTANEOUS T-CELL LYMPHOMA and SEZARY SYNDROME.
vorinostat : A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Epilepsy is a spectrum of neurological disorders with many causal factors." | 1.46 | Inhibitory synapse deficits caused by familial α1 GABA ( Chen, X; Durisic, N; Keramidas, A; Lynch, JW, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Lunke, S | 1 |
| Maxwell, S | 1 |
| Khurana, I | 1 |
| K N, H | 1 |
| Okabe, J | 1 |
| Al-Hasani, K | 1 |
| El-Osta, A | 1 |
| Chen, X | 1 |
| Durisic, N | 1 |
| Lynch, JW | 1 |
| Keramidas, A | 1 |
| Di, XJ | 1 |
| Han, DY | 1 |
| Wang, YJ | 1 |
| Chance, MR | 1 |
| Mu, TW | 1 |
3 other studies available for vorinostat and Epilepsy
| Article | Year |
|---|---|
Epigenetic evidence of an Ac/Dc axis by VPA and SAHA.
Topics: Acetylation; Cells, Cultured; Epigenesis, Genetic; Epilepsy; Gene Expression Regulation; Histone Dea | 2021 |
Inhibitory synapse deficits caused by familial α1 GABA
Topics: Animals; Anticonvulsants; Carbamazepine; Cerebral Cortex; Coculture Techniques; Epilepsy; HEK293 Cel | 2017 |
SAHA enhances Proteostasis of epilepsy-associated α1(A322D)β2γ2 GABA(A) receptors.
Topics: Calnexin; Epilepsy; gamma-Aminobutyric Acid; HEK293 Cells; Histone Deacetylase Inhibitors; Humans; H | 2013 |