vorinostat has been researched along with Endometrial Neoplasms in 10 studies
Vorinostat: A hydroxamic acid and anilide derivative that acts as a HISTONE DEACETYLASE inhibitor. It is used in the treatment of CUTANEOUS T-CELL LYMPHOMA and SEZARY SYNDROME.
vorinostat : A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).
Endometrial Neoplasms: Tumors or cancer of ENDOMETRIUM, the mucous lining of the UTERUS. These neoplasms can be benign or malignant. Their classification and grading are based on the various cell types and the percent of undifferentiated cells.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We have reported previously that treatment with HDACIs, including trichostatin A and suberoylanilide hydroxamic acid (SAHA) or progesterone in combination with estrogen, can induce cytodifferentiation of endometrial adenocarcinoma Ishikawa cells through up-regulation of glycodelin, a progesterone-induced endometrial glycoprotein." | 3.74 | Histone deacetylase inhibitors stimulate cell migration in human endometrial adenocarcinoma cells through up-regulation of glycodelin. ( Arase, T; Asada, H; Kajitani, T; Maruyama, T; Masuda, H; Nagashima, T; Ohta, K; Ono, M; Uchida, H; Yoshimura, Y, 2007) |
| " In this study, we show that TSA and SAHA, belonging to the hydroxamic acid group of HDACIs, can induce the phenotype of a human endometrial adenocarcinoma cell line, Ishikawa (originally derived from the glandular component of the endometrium), to differentiate to closely resemble normal endometrial epithelium in a time- and dose-dependent manner, as determined by morphological changes, synthesis of glycogen, and expression of secretory phase-specific proteins, including glycodelin." | 3.73 | Histone deacetylase inhibitors induce differentiation of human endometrial adenocarcinoma cells through up-regulation of glycodelin. ( Asada, H; Maruyama, T; Nagashima, T; Uchida, H; Yoshimura, Y, 2005) |
| "Endometrial stromal sarcomas are rare and molecular mechanisms involved in their pathogenesis are poorly understood." | 1.35 | SAHA induces caspase-independent, autophagic cell death of endometrial stromal sarcoma cells by influencing the mTOR pathway. ( Denk, H; Hrzenjak, A; Kremser, ML; Moinfar, F; Strohmeier, B; Zatloukal, K, 2008) |
| "Endometrial and ovarian cancer cells were treated with various concentrations of M344, and its effect on cell growth, cell cycle, apoptosis, and related measurements was investigated." | 1.33 | M344 is a novel synthesized histone deacetylase inhibitor that induces growth inhibition, cell cycle arrest, and apoptosis in human endometrial cancer and ovarian cancer cells. ( Narahara, H; Nasu, K; Nishida, M; Takai, N; Ueda, T, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (50.00) | 29.6817 |
| 2010's | 5 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bergadà , L | 2 |
| Sorolla, A | 2 |
| Yeramian, A | 2 |
| Eritja, N | 1 |
| Mirantes, C | 1 |
| Matias-Guiu, X | 2 |
| Dolcet, X | 2 |
| Ren, J | 1 |
| Zhang, J | 1 |
| Cai, H | 1 |
| Li, Y | 1 |
| Zhang, Y | 1 |
| Zhang, X | 1 |
| Zhao, D | 1 |
| Li, Z | 1 |
| Ma, H | 1 |
| Wang, J | 1 |
| Gao, YE | 1 |
| Xiao, L | 1 |
| Liu, R | 1 |
| Qian, J | 1 |
| Liu, Y | 1 |
| Wei, H | 1 |
| Li, J | 1 |
| Hrzenjak, A | 1 |
| Kremser, ML | 1 |
| Strohmeier, B | 1 |
| Moinfar, F | 1 |
| Zatloukal, K | 1 |
| Denk, H | 1 |
| Sarfstein, R | 1 |
| Bruchim, I | 1 |
| Fishman, A | 1 |
| Werner, H | 1 |
| Mendivil, AA | 1 |
| Micha, JP | 1 |
| Brown, JV | 1 |
| Rettenmaier, MA | 1 |
| Abaid, LN | 1 |
| Lopez, KL | 1 |
| Goldstein, BH | 1 |
| Takai, N | 2 |
| Desmond, JC | 1 |
| Kumagai, T | 1 |
| Gui, D | 1 |
| Said, JW | 1 |
| Whittaker, S | 1 |
| Miyakawa, I | 1 |
| Koeffler, HP | 1 |
| Uchida, H | 2 |
| Maruyama, T | 2 |
| Nagashima, T | 2 |
| Asada, H | 2 |
| Yoshimura, Y | 2 |
| Ueda, T | 1 |
| Nishida, M | 1 |
| Nasu, K | 1 |
| Narahara, H | 1 |
| Ono, M | 1 |
| Ohta, K | 1 |
| Kajitani, T | 1 |
| Masuda, H | 1 |
| Arase, T | 1 |
1 review available for vorinostat and Endometrial Neoplasms
| Article | Year |
|---|---|
HDAC as a therapeutic target for treatment of endometrial cancers.
Topics: Animals; Antineoplastic Agents; Apoptosis; DNA Methylation; Endometrial Neoplasms; Epigenesis, Genet | 2014 |
1 trial available for vorinostat and Endometrial Neoplasms
| Article | Year |
|---|---|
Increased incidence of severe gastrointestinal events with first-line paclitaxel, carboplatin, and vorinostat chemotherapy for advanced-stage epithelial ovarian, primary peritoneal, and fallopian tube cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Cystadenocarcinoma, Serous | 2013 |
8 other studies available for vorinostat and Endometrial Neoplasms
| Article | Year |
|---|---|
Combination of Vorinostat and caspase-8 inhibition exhibits high anti-tumoral activity on endometrial cancer cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Caspase 8; Cell Line, Tumor; Endometri | 2013 |
Antioxidants impair anti-tumoral effects of Vorinostat, but not anti-neoplastic effects of Vorinostat and caspase-8 downregulation.
Topics: Animals; Antineoplastic Agents; Antioxidants; Apoptosis; Caspase 8; Cell Line, Tumor; Cell Survival; | 2014 |
SAHA induces caspase-independent, autophagic cell death of endometrial stromal sarcoma cells by influencing the mTOR pathway.
Topics: Autophagy; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; | 2008 |
The mechanism of action of the histone deacetylase inhibitor vorinostat involves interaction with the insulin-like growth factor signaling pathway.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Apoptosis; Cell Cy | 2011 |
Histone deacetylase inhibitors have a profound antigrowth activity in endometrial cancer cells.
Topics: Agar; Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Cadherins; Cell Cycle Proteins; | 2004 |
Histone deacetylase inhibitors induce differentiation of human endometrial adenocarcinoma cells through up-regulation of glycodelin.
Topics: Adenocarcinoma; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Endometrial Neoplasms; E | 2005 |
M344 is a novel synthesized histone deacetylase inhibitor that induces growth inhibition, cell cycle arrest, and apoptosis in human endometrial cancer and ovarian cancer cells.
Topics: Acetylation; Apoptosis; Cadherins; Cell Cycle; Cell Growth Processes; Cell Line, Tumor; Cyclin-Depen | 2006 |
Histone deacetylase inhibitors stimulate cell migration in human endometrial adenocarcinoma cells through up-regulation of glycodelin.
Topics: Adenocarcinoma; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Endometrial Neoplasms; Enzym | 2007 |