vorinostat has been researched along with Delayed Effects, Prenatal Exposure in 3 studies
Vorinostat: A hydroxamic acid and anilide derivative that acts as a HISTONE DEACETYLASE inhibitor. It is used in the treatment of CUTANEOUS T-CELL LYMPHOMA and SEZARY SYNDROME.
vorinostat : A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sevoflurane is a widely used volatile anesthetic in clinical practice." | 1.51 | Suberoylanilide hydroxamic acid (SAHA) alleviates the learning and memory impairment in rat offspring caused by maternal sevoflurane exposure during late gestation. ( Feng, N; Hu, Y; Li, M; Liu, Y; Liu, Z; Luo, F; Wu, L; Xu, L; Yu, Q; Zhao, W, 2019) |
| " Our previous studies have demonstrated the social cognition deficits observed in this model, a major core symptom of ASD, to be ameliorated following chronic administration of histone deacetylase (HDAC) inhibitors." | 1.40 | Pentyl-4-yn-VPA, a histone deacetylase inhibitor, ameliorates deficits in social behavior and cognition in a rodent model of autism spectrum disorders. ( Cassidy, AW; Foley, AG; Regan, CM, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lin, J | 1 |
| Wang, S | 1 |
| Feng, Y | 1 |
| Zhao, W | 4 |
| Luo, F | 2 |
| Feng, N | 2 |
| Yu, Q | 1 |
| Hu, Y | 1 |
| Liu, Z | 1 |
| Li, M | 1 |
| Xu, L | 1 |
| Wu, L | 1 |
| Liu, Y | 1 |
| Foley, AG | 1 |
| Cassidy, AW | 1 |
| Regan, CM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A 12-weeks, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy, Safety and Related Mechanism of Sulforaphane in Treatment of Autism Spectrum Disorder[NCT02879110] | 110 participants (Actual) | Interventional | 2016-08-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 other studies available for vorinostat and Delayed Effects, Prenatal Exposure
| Article | Year |
|---|---|
Propofol exposure during early gestation impairs learning and memory in rat offspring by inhibiting the acetylation of histone.
Topics: Acetylation; Anesthesia; Animals; Cyclic AMP Response Element-Binding Protein; Down-Regulation; Drug | 2018 |
Suberoylanilide hydroxamic acid (SAHA) alleviates the learning and memory impairment in rat offspring caused by maternal sevoflurane exposure during late gestation.
Topics: Anesthetics, Inhalation; Animals; Cyclic AMP Response Element-Binding Protein; Female; Hippocampus; | 2019 |
Pentyl-4-yn-VPA, a histone deacetylase inhibitor, ameliorates deficits in social behavior and cognition in a rodent model of autism spectrum disorders.
Topics: Acetylation; Animals; Behavior, Animal; Cerebellar Cortex; Child Development Disorders, Pervasive; C | 2014 |