vorinostat has been researched along with Cystic Fibrosis in 5 studies
Vorinostat: A hydroxamic acid and anilide derivative that acts as a HISTONE DEACETYLASE inhibitor. It is used in the treatment of CUTANEOUS T-CELL LYMPHOMA and SEZARY SYNDROME.
vorinostat : A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).
Cystic Fibrosis: An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (80.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hutt, DM | 1 |
| Herman, D | 1 |
| Rodrigues, AP | 1 |
| Noel, S | 1 |
| Pilewski, JM | 1 |
| Matteson, J | 1 |
| Hoch, B | 1 |
| Kellner, W | 1 |
| Kelly, JW | 1 |
| Schmidt, A | 1 |
| Thomas, PJ | 1 |
| Matsumura, Y | 1 |
| Skach, WR | 1 |
| Gentzsch, M | 1 |
| Riordan, JR | 1 |
| Sorscher, EJ | 2 |
| Okiyoneda, T | 1 |
| Yates, JR | 1 |
| Lukacs, GL | 1 |
| Frizzell, RA | 1 |
| Manning, G | 1 |
| Gottesfeld, JM | 1 |
| Balch, WE | 1 |
| Barone, S | 1 |
| Cassese, E | 1 |
| Alfano, AI | 1 |
| Brindisi, M | 1 |
| Summa, V | 1 |
| Bergougnoux, A | 1 |
| Petit, A | 1 |
| Knabe, L | 1 |
| Bribes, E | 1 |
| Chiron, R | 1 |
| De Sario, A | 1 |
| Claustres, M | 1 |
| Molinari, N | 1 |
| Vachier, I | 1 |
| Taulan-Cadars, M | 1 |
| Bourdin, A | 1 |
| Chung, WJ | 1 |
| Goeckeler-Fried, JL | 1 |
| Havasi, V | 1 |
| Chiang, A | 1 |
| Rowe, SM | 1 |
| Plyler, ZE | 1 |
| Hong, JS | 1 |
| Mazur, M | 1 |
| Piazza, GA | 1 |
| Keeton, AB | 1 |
| White, EL | 1 |
| Rasmussen, L | 1 |
| Weissman, AM | 1 |
| Denny, RA | 1 |
| Brodsky, JL | 1 |
| Sondo, E | 1 |
| Tomati, V | 1 |
| Caci, E | 1 |
| Esposito, AI | 1 |
| Pfeffer, U | 1 |
| Pedemonte, N | 1 |
| Galietta, LJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Defining Epigenetic Regulation of Immunity in Alpha-1 Anti-trypsin Deficiency[NCT02691611] | 39 participants (Actual) | Observational | 2015-12-31 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for vorinostat and Cystic Fibrosis
| Article | Year |
|---|---|
Chasing a Breath of Fresh Air in Cystic Fibrosis (CF): Therapeutic Potential of Selective HDAC6 Inhibitors to Tackle Multiple Pathways in CF Pathophysiology.
Topics: Animals; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Histone Deacetylase 6 | 2022 |
4 other studies available for vorinostat and Cystic Fibrosis
| Article | Year |
|---|---|
Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis.
Topics: Animals; Bronchi; Cell Membrane; Cricetinae; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conducta | 2010 |
The HDAC inhibitor SAHA does not rescue CFTR membrane expression in Cystic Fibrosis.
Topics: Cell Membrane; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Epithelium; Fem | 2017 |
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regu | 2016 |
Rescue of the mutant CFTR chloride channel by pharmacological correctors and low temperature analyzed by gene expression profiling.
Topics: Aminacrine; Bacterial Proteins; Benzamides; Cell Line; Cell Membrane; Chlorides; Ciclopirox; Cold Te | 2011 |