vorinostat has been researched along with Corneal Opacity in 3 studies
Vorinostat: A hydroxamic acid and anilide derivative that acts as a HISTONE DEACETYLASE inhibitor. It is used in the treatment of CUTANEOUS T-CELL LYMPHOMA and SEZARY SYNDROME.
vorinostat : A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).
Corneal Opacity: Disorder occurring in the central or peripheral area of the cornea. The usual degree of transparency becomes relatively opaque.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study investigated the efficacy and safety of vorinostat, a deacetylase (HDAC) inhibitor, in the treatment of laser-induced corneal haze following photorefractive keratectomy (PRK) in rabbits in vivo and transforming growth factor beta 1 (TGFβ1) -induced corneal fibrosis in vitro." | 3.78 | Vorinostat: a potent agent to prevent and treat laser-induced corneal haze. ( Cowden, JW; Gibson, DJ; Liu, Y; Mohan, RR; Schultz, GS; Sharma, A; Tandon, A; Tovey, JC; Waggoner, MR, 2012) |
| " Furthermore, SAHA dosing did not compromise corneal endothelial phenotype, density, or function in rabbit eyes, whereas MMC application did (P < ." | 1.46 | Efficacy and Safety Comparison Between Suberoylanilide Hydroxamic Acid and Mitomycin C in Reducing the Risk of Corneal Haze After PRK Treatment In Vivo. ( Anumanthan, G; Gupta, S; Hamm, CW; Hesemann, NP; Mohan, RR; Sharma, A; Waggoner, M, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Anumanthan, G | 1 |
| Sharma, A | 2 |
| Waggoner, M | 1 |
| Hamm, CW | 1 |
| Gupta, S | 1 |
| Hesemann, NP | 1 |
| Mohan, RR | 2 |
| Berkowski, WM | 1 |
| Gibson, DJ | 2 |
| Seo, S | 1 |
| Proietto, LR | 1 |
| Whitley, RD | 1 |
| Schultz, GS | 2 |
| Plummer, CE | 1 |
| Tandon, A | 1 |
| Tovey, JC | 1 |
| Waggoner, MR | 1 |
| Cowden, JW | 1 |
| Liu, Y | 1 |
3 other studies available for vorinostat and Corneal Opacity
| Article | Year |
|---|---|
Efficacy and Safety Comparison Between Suberoylanilide Hydroxamic Acid and Mitomycin C in Reducing the Risk of Corneal Haze After PRK Treatment In Vivo.
Topics: Alkylating Agents; Animals; Apoptosis; Cornea; Corneal Opacity; Disease Models, Animal; Fluorescent | 2017 |
Assessment of Topical Therapies for Improving the Optical Clarity Following Stromal Wounding in a Novel Ex Vivo Canine Cornea Model.
Topics: Actins; Administration, Ophthalmic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Connective Tis | 2018 |
Vorinostat: a potent agent to prevent and treat laser-induced corneal haze.
Topics: Actins; Animals; Cells, Cultured; Cornea; Corneal Keratocytes; Corneal Opacity; Dose-Response Relati | 2012 |