vorinostat has been researched along with Corneal Injuries in 4 studies
Vorinostat: A hydroxamic acid and anilide derivative that acts as a HISTONE DEACETYLASE inhibitor. It is used in the treatment of CUTANEOUS T-CELL LYMPHOMA and SEZARY SYNDROME.
vorinostat : A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).
Corneal Injuries: Damage or trauma inflicted to the CORNEA by external means.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We have previously reported that vorinostat, an FDA-approved, clinically used histone deacetylase (HDAC) inhibitor, attenuates corneal fibrosis in vivo in rabbits by blocking transforming growth factor β (TGFβ)." | 7.81 | Role of 5'TG3'-interacting factors (TGIFs) in Vorinostat (HDAC inhibitor)-mediated Corneal Fibrosis Inhibition. ( Mohan, RR; Sharma, A; Siddiqui, S; Sinha, NR, 2015) |
| "We have previously reported that vorinostat, an FDA-approved, clinically used histone deacetylase (HDAC) inhibitor, attenuates corneal fibrosis in vivo in rabbits by blocking transforming growth factor β (TGFβ)." | 3.81 | Role of 5'TG3'-interacting factors (TGIFs) in Vorinostat (HDAC inhibitor)-mediated Corneal Fibrosis Inhibition. ( Mohan, RR; Sharma, A; Siddiqui, S; Sinha, NR, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Berkowski, WM | 1 |
| Gibson, DJ | 1 |
| Seo, S | 1 |
| Proietto, LR | 1 |
| Whitley, RD | 1 |
| Schultz, GS | 1 |
| Plummer, CE | 1 |
| Donnelly, KS | 1 |
| Giuliano, EA | 1 |
| Sharm, A | 1 |
| Mohan, RR | 2 |
| Sharma, A | 1 |
| Sinha, NR | 1 |
| Siddiqui, S | 1 |
| Li, X | 1 |
| Zhou, Q | 1 |
| Hanus, J | 1 |
| Anderson, C | 1 |
| Zhang, H | 1 |
| Dellinger, M | 1 |
| Brekken, R | 1 |
| Wang, S | 1 |
4 other studies available for vorinostat and Corneal Injuries
| Article | Year |
|---|---|
Assessment of Topical Therapies for Improving the Optical Clarity Following Stromal Wounding in a Novel Ex Vivo Canine Cornea Model.
Topics: Actins; Administration, Ophthalmic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Connective Tis | 2018 |
Suberoylanilide hydroxamic acid (vorinostat): its role on equine corneal fibrosis and matrix metalloproteinase activity.
Topics: Animals; Cell Survival; Cicatrix; Corneal Injuries; Corneal Keratocytes; Histone Deacetylase Inhibit | 2014 |
Role of 5'TG3'-interacting factors (TGIFs) in Vorinostat (HDAC inhibitor)-mediated Corneal Fibrosis Inhibition.
Topics: Cell Transdifferentiation; Cells, Cultured; Cornea; Corneal Diseases; Corneal Injuries; Fibroblasts; | 2015 |
Inhibition of multiple pathogenic pathways by histone deacetylase inhibitor SAHA in a corneal alkali-burn injury model.
Topics: Alkalies; Animals; Burns, Chemical; Cornea; Corneal Diseases; Corneal Injuries; Corneal Neovasculari | 2013 |