vorinostat has been researched along with Colitis in 4 studies
Vorinostat: A hydroxamic acid and anilide derivative that acts as a HISTONE DEACETYLASE inhibitor. It is used in the treatment of CUTANEOUS T-CELL LYMPHOMA and SEZARY SYNDROME.
vorinostat : A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).
Colitis: Inflammation of the COLON section of the large intestine (INTESTINE, LARGE), usually with symptoms such as DIARRHEA (often with blood and mucus), ABDOMINAL PAIN, and FEVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Valproic acid (VPA) and suberyolanilide hydroxamic acid (SAHA) were chosen for further studies in dextran sulfate sodium- and trinitrobenzene sulfonic acid-induced colitis in mice." | 3.73 | Histone hyperacetylation is associated with amelioration of experimental colitis in mice. ( Batra, A; Dinarello, CA; Fantuzzi, G; Fedke, I; Glauben, R; Lehr, HA; Leoni, F; Mascagni, P; Siegmund, B; Zeitz, M, 2006) |
| "Givinostat treatment mediated an accelerated wound closure in scratch assays." | 1.51 | HDAC inhibitors promote intestinal epithelial regeneration via autocrine TGFβ1 signalling in inflammation. ( Friedrich, M; Gerbeth, L; Gerling, M; Glauben, R; Keye, J; Rosenthal, R; Schmidt, F; Siegmund, B; Steiger, K; Weichert, W; Weidinger, C; Wu, H, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wetzel, A | 1 |
| Scholtka, B | 1 |
| Gerecke, C | 1 |
| Kleuser, B | 1 |
| Friedrich, M | 1 |
| Gerbeth, L | 1 |
| Gerling, M | 1 |
| Rosenthal, R | 1 |
| Steiger, K | 1 |
| Weidinger, C | 1 |
| Keye, J | 1 |
| Wu, H | 1 |
| Schmidt, F | 1 |
| Weichert, W | 1 |
| Siegmund, B | 3 |
| Glauben, R | 3 |
| Batra, A | 2 |
| Fedke, I | 2 |
| Zeitz, M | 2 |
| Lehr, HA | 2 |
| Leoni, F | 2 |
| Mascagni, P | 2 |
| Fantuzzi, G | 1 |
| Dinarello, CA | 2 |
| Stroh, T | 1 |
| Erben, U | 1 |
4 other studies available for vorinostat and Colitis
| Article | Year |
|---|---|
Epigenetic histone modulation contributes to improvements in inflammatory bowel disease via EBI3.
Topics: Animals; Caspase 3; CD3 Complex; Colitis; Dextran Sulfate; Epigenesis, Genetic; Histone Deacetylase | 2020 |
HDAC inhibitors promote intestinal epithelial regeneration via autocrine TGFβ1 signalling in inflammation.
Topics: Animals; Autocrine Communication; Carbamates; Cells, Cultured; Colitis; Disease Models, Animal; Elec | 2019 |
Histone hyperacetylation is associated with amelioration of experimental colitis in mice.
Topics: Acetylation; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Colitis; Cytokines; Diseas | 2006 |
Histone deacetylases: novel targets for prevention of colitis-associated cancer in mice.
Topics: Animals; Anti-Inflammatory Agents; Anticarcinogenic Agents; Apoptosis; Colitis; Colonic Neoplasms; C | 2008 |