Page last updated: 2024-11-04

vorinostat and Central Nervous System Neoplasm

vorinostat has been researched along with Central Nervous System Neoplasm in 2 studies

Vorinostat: A hydroxamic acid and anilide derivative that acts as a HISTONE DEACETYLASE inhibitor. It is used in the treatment of CUTANEOUS T-CELL LYMPHOMA and SEZARY SYNDROME.
vorinostat : A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).

Research Excerpts

ExcerptRelevanceReference
" Histone deacetylase inhibitors (HDACIs) represent a class of agents that can modulate gene expression to reduce tumor growth, and we and others have noted some antiglioma activity from HDACIs, such as vorinostat, although insufficient to warrant use as monotherapy."7.79Bortezomib-induced sensitization of malignant human glioma cells to vorinostat-induced apoptosis depends on reactive oxygen species production, mitochondrial dysfunction, Noxa upregulation, Mcl-1 cleavage, and DNA damage. ( Agostino, NR; DiDomenico, JD; Jane, EP; Pollack, IF; Premkumar, DR, 2013)
" Histone deacetylase inhibitors (HDACIs) represent a class of agents that can modulate gene expression to reduce tumor growth, and we and others have noted some antiglioma activity from HDACIs, such as vorinostat, although insufficient to warrant use as monotherapy."3.79Bortezomib-induced sensitization of malignant human glioma cells to vorinostat-induced apoptosis depends on reactive oxygen species production, mitochondrial dysfunction, Noxa upregulation, Mcl-1 cleavage, and DNA damage. ( Agostino, NR; DiDomenico, JD; Jane, EP; Pollack, IF; Premkumar, DR, 2013)
"Vorinostat was tolerated without serious adverse events by all patients."1.91Proteostasis Modulation in Germline Missense von Hippel Lindau Disease. ( Alvarez, R; Asuzu, DT; Bugarini, A; Chew, EY; Chittiboina, P; Elkahloun, A; Linehan, M; Lonser, RR; Mandal, D; Maric, D; Mastorakos, P; Mullaney, D; Scott, G; Stoica, S; Yang, C; Zhuang, Z, 2023)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (50.00)24.3611
2020's1 (50.00)2.80

Authors

AuthorsStudies
Chittiboina, P1
Mandal, D1
Bugarini, A1
Asuzu, DT1
Mullaney, D1
Mastorakos, P1
Stoica, S1
Alvarez, R1
Scott, G1
Maric, D1
Elkahloun, A1
Zhuang, Z1
Chew, EY1
Yang, C1
Linehan, M1
Lonser, RR1
Premkumar, DR1
Jane, EP1
Agostino, NR1
DiDomenico, JD1
Pollack, IF1

Other Studies

2 other studies available for vorinostat and Central Nervous System Neoplasm

ArticleYear
Proteostasis Modulation in Germline Missense von Hippel Lindau Disease.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2023, 06-13, Volume: 29, Issue:12

    Topics: Biological Products; Central Nervous System Neoplasms; Hemangioblastoma; Humans; Proteostasis; von H

2023
Bortezomib-induced sensitization of malignant human glioma cells to vorinostat-induced apoptosis depends on reactive oxygen species production, mitochondrial dysfunction, Noxa upregulation, Mcl-1 cleavage, and DNA damage.
    Molecular carcinogenesis, 2013, Volume: 52, Issue:2

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis Regulato

2013