Page last updated: 2024-11-04

vorinostat and Cancer of Skin

vorinostat has been researched along with Cancer of Skin in 55 studies

Vorinostat: A hydroxamic acid and anilide derivative that acts as a HISTONE DEACETYLASE inhibitor. It is used in the treatment of CUTANEOUS T-CELL LYMPHOMA and SEZARY SYNDROME.
vorinostat : A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).

Research Excerpts

ExcerptRelevanceReference
"Vorinostat is a small molecule inhibitor of class I and II histone deacetylases with preclinical activity in melanoma."9.19Phase II trial of vorinostat in advanced melanoma. ( Adams, PD; Alpaugh, RK; Haas, NB; Hotte, S; Litwin, S; Martin, LP; McBryan, T; McWhirter, E; Oza, A; Polintan, R; Quirt, I; vonMehren, M; Wang, L; Zweibel, J, 2014)
"A phase I study was conducted to evaluate the safety, tolerability, pharmacokinetics (PK) and efficacy of the oral histone deacetylase (HDAC) inhibitor vorinostat in Japanese patients with relapsed or refractory cutaneous T-cell lymphoma (CTCL)."9.16Phase I and pharmacokinetic study of the oral histone deacetylase inhibitor vorinostat in Japanese patients with relapsed or refractory cutaneous T-cell lymphoma. ( Hamada, T; Iwatsuki, K; Kato, Y; Noguchi, K; Shimamoto, T; Sugaya, M; Tobinai, K; Tsuboi, R; Wada, H, 2012)
"Vorinostat, an orally active histone deacetylase inhibitor, was approved in October 2006 by the US Food and Drug Administration for the treatment of cutaneous manifestations of cutaneous T-cell lymphoma (CTCL) in patients with progressive, persistent, or recurrent disease during or after treatment with 2 systemic therapies."9.14Evaluation of the long-term tolerability and clinical benefit of vorinostat in patients with advanced cutaneous T-cell lymphoma. ( Abuav, R; Boileau, K; Breneman, D; Chen, C; Duvic, M; Geskin, LJ; Gunchenko, A; Olsen, EA; Pacheco, TR; Parker, S; Ricker, JL; Rizvi, S; Sanz-Rodriguez, C; Vonderheid, EC, 2009)
"To evaluate the activity and safety of the histone deacetylase inhibitor vorinostat (suberoylanilide hydroxamic acid) in persistent, progressive, or recurrent mycosis fungoides or Sézary syndrome (MF/SS) cutaneous t-cell lymphoma (CTCL) subtypes."9.12Phase IIb multicenter trial of vorinostat in patients with persistent, progressive, or treatment refractory cutaneous T-cell lymphoma. ( Arduino, JM; Chen, C; Duvic, M; Foss, FM; Frankel, SR; Kim, YH; Kuzel, TM; Olsen, EA; Pacheco, TR; Parker, S; Ricker, JL, 2007)
"The pharmacology, pharmacokinetics, clinical efficacy, safety, adverse effects, dosage and administration, and role in therapy of vorinostat in the treatment of cutaneous T-cell lymphoma (CTCL) are reviewed."8.86Vorinostat: A novel therapy for the treatment of cutaneous T-cell lymphoma. ( Kavanaugh, SA; Kavanaugh, SM; Kolesar, JM; White, LA, 2010)
"We describe a 34-year-old Japanese man with syringotropic CD8+ mycosis fungoides (MF) accompanied by hypohidrosis who was treated with vorinostat and retinoids."7.79Successful treatment of syringotropic CD8+ mycosis fungoides accompanied by hypohidrosis with vorinostat and retinoids. ( Aiba, S; Fujimura, T; Kakizaki, A; Kambayashi, Y; Mizuashi, M; Watabe, A, 2013)
"Vorinostat (suberoylanilide hydroxamic acid, SAHA), an inhibitor of class I and II histone deacetylases, has been approved for the treatment of cutaneous T-cell lymphoma."7.76Vorinostat interferes with the signaling transduction pathway of T-cell receptor and synergizes with phosphoinositide-3 kinase inhibitors in cutaneous T-cell lymphoma. ( Aparicio, CB; Bischoff, JR; de La Cueva, P; Herrera, M; Herreros, B; Longo, MI; Martin-Perez, D; Martínez Leal, JF; Ortiz-Romero, PL; Piris, MA; Rodriguez, ME; Villuendas, R; Wozniak, MB, 2010)
"Vorinostat is a histone deacetylase inhibitor that induces differentiation, growth arrest, and/or apoptosis of malignant cells both in vitro and in vivo and has shown clinical responses in approximately 30% of patients with advanced mycosis fungoides and Sézary syndrome cutaneous T-cell lymphoma (CTCL)."7.74Constitutive activation of signal transducers and activators of transcription predicts vorinostat resistance in cutaneous T-cell lymphoma. ( Fantin, VR; Frankel, SR; Gooden, F; Harrington, EA; Hendrickson, RC; Hou, XS; Kadin, ME; Korenchuk, S; Li, L; Loboda, A; Paweletz, CP; Pierce, JW; Randolph, S; Reilly, JF; Richon, VM; Roth, JA; Ware, CM, 2008)
" We report on a 51-year-old patient with tumor-stage mycosis fungoides who developed several unusual features such as extensive necrosis of lymphoma lesions, granulomatous reaction, and venular thromboses while under treatment with bexarotene, vorinostat, and high-dose fenofibrate."7.74Complete clinical remission of tumor-stage mycosis fungoides after acute extensive skin necroses, granulomatous reaction, and fever under treatment with bexarotene, vorinostat, and high-dose fenofibrate. ( Assaf, C; Beyer, M; Lukowsky, A; Roewert-Huber, J; Steinhoff, M; Sterry, W, 2008)
"Vorinostat is a small molecule inhibitor of class I and II histone deacetylases with preclinical activity in melanoma."5.19Phase II trial of vorinostat in advanced melanoma. ( Adams, PD; Alpaugh, RK; Haas, NB; Hotte, S; Litwin, S; Martin, LP; McBryan, T; McWhirter, E; Oza, A; Polintan, R; Quirt, I; vonMehren, M; Wang, L; Zweibel, J, 2014)
"A phase I study was conducted to evaluate the safety, tolerability, pharmacokinetics (PK) and efficacy of the oral histone deacetylase (HDAC) inhibitor vorinostat in Japanese patients with relapsed or refractory cutaneous T-cell lymphoma (CTCL)."5.16Phase I and pharmacokinetic study of the oral histone deacetylase inhibitor vorinostat in Japanese patients with relapsed or refractory cutaneous T-cell lymphoma. ( Hamada, T; Iwatsuki, K; Kato, Y; Noguchi, K; Shimamoto, T; Sugaya, M; Tobinai, K; Tsuboi, R; Wada, H, 2012)
"Vorinostat, an orally active histone deacetylase inhibitor, was approved in October 2006 by the US Food and Drug Administration for the treatment of cutaneous manifestations of cutaneous T-cell lymphoma (CTCL) in patients with progressive, persistent, or recurrent disease during or after treatment with 2 systemic therapies."5.14Evaluation of the long-term tolerability and clinical benefit of vorinostat in patients with advanced cutaneous T-cell lymphoma. ( Abuav, R; Boileau, K; Breneman, D; Chen, C; Duvic, M; Geskin, LJ; Gunchenko, A; Olsen, EA; Pacheco, TR; Parker, S; Ricker, JL; Rizvi, S; Sanz-Rodriguez, C; Vonderheid, EC, 2009)
"To evaluate the activity and safety of the histone deacetylase inhibitor vorinostat (suberoylanilide hydroxamic acid) in persistent, progressive, or recurrent mycosis fungoides or Sézary syndrome (MF/SS) cutaneous t-cell lymphoma (CTCL) subtypes."5.12Phase IIb multicenter trial of vorinostat in patients with persistent, progressive, or treatment refractory cutaneous T-cell lymphoma. ( Arduino, JM; Chen, C; Duvic, M; Foss, FM; Frankel, SR; Kim, YH; Kuzel, TM; Olsen, EA; Pacheco, TR; Parker, S; Ricker, JL, 2007)
"Vorinostat is a histone deacetylase inhibitor used in the treatment of recurrent or persistent cases of cutaneous T-cell lymphoma (CTCL)."4.88QT interval prolongation and torsades de pointes in a patient undergoing treatment with vorinostat: a case report and review of the literature. ( Lynch, DR; Newby, LK; Washam, JB, 2012)
"The pharmacology, pharmacokinetics, clinical efficacy, safety, adverse effects, dosage and administration, and role in therapy of vorinostat in the treatment of cutaneous T-cell lymphoma (CTCL) are reviewed."4.86Vorinostat: A novel therapy for the treatment of cutaneous T-cell lymphoma. ( Kavanaugh, SA; Kavanaugh, SM; Kolesar, JM; White, LA, 2010)
"We describe a 34-year-old Japanese man with syringotropic CD8+ mycosis fungoides (MF) accompanied by hypohidrosis who was treated with vorinostat and retinoids."3.79Successful treatment of syringotropic CD8+ mycosis fungoides accompanied by hypohidrosis with vorinostat and retinoids. ( Aiba, S; Fujimura, T; Kakizaki, A; Kambayashi, Y; Mizuashi, M; Watabe, A, 2013)
"Vorinostat (suberoylanilide hydroxamic acid, SAHA), an inhibitor of class I and II histone deacetylases, has been approved for the treatment of cutaneous T-cell lymphoma."3.76Vorinostat interferes with the signaling transduction pathway of T-cell receptor and synergizes with phosphoinositide-3 kinase inhibitors in cutaneous T-cell lymphoma. ( Aparicio, CB; Bischoff, JR; de La Cueva, P; Herrera, M; Herreros, B; Longo, MI; Martin-Perez, D; Martínez Leal, JF; Ortiz-Romero, PL; Piris, MA; Rodriguez, ME; Villuendas, R; Wozniak, MB, 2010)
"Vorinostat is a histone deacetylase inhibitor that induces differentiation, growth arrest, and/or apoptosis of malignant cells both in vitro and in vivo and has shown clinical responses in approximately 30% of patients with advanced mycosis fungoides and Sézary syndrome cutaneous T-cell lymphoma (CTCL)."3.74Constitutive activation of signal transducers and activators of transcription predicts vorinostat resistance in cutaneous T-cell lymphoma. ( Fantin, VR; Frankel, SR; Gooden, F; Harrington, EA; Hendrickson, RC; Hou, XS; Kadin, ME; Korenchuk, S; Li, L; Loboda, A; Paweletz, CP; Pierce, JW; Randolph, S; Reilly, JF; Richon, VM; Roth, JA; Ware, CM, 2008)
" We report on a 51-year-old patient with tumor-stage mycosis fungoides who developed several unusual features such as extensive necrosis of lymphoma lesions, granulomatous reaction, and venular thromboses while under treatment with bexarotene, vorinostat, and high-dose fenofibrate."3.74Complete clinical remission of tumor-stage mycosis fungoides after acute extensive skin necroses, granulomatous reaction, and fever under treatment with bexarotene, vorinostat, and high-dose fenofibrate. ( Assaf, C; Beyer, M; Lukowsky, A; Roewert-Huber, J; Steinhoff, M; Sterry, W, 2008)
"Bexarotene was investigated in one trial each with vorinostat, methotrexate or gemcitabine, whereby only methotrexate possibly enhanced the effect of bexarotene."2.50Systematic review of combination therapies for mycosis fungoides. ( Beyer, M; Erdmann, R; Humme, D; Nast, A; Vandersee, S, 2014)
"The cause of mycosis fungoides is unknown and, with the possible exception of very early stage disease, no cure is available."2.43Treatment of cutaneous T-cell lymphoma/mycosis fungoides. ( Bradley, B; Parker, SR, 2006)
"This study was conducted to identify novel therapeutic targets that can be combined with HDACis for treating CTCL."1.62Kinome profiling analysis identified Src pathway as a novel therapeutic target in combination with histone deacetylase inhibitors for cutaneous T-cell lymphoma. ( Fujii, K; Jimura, N; Kanekura, T; Kondo, T; Qiao, Z; Tsuchiya, R; Yoshimatsu, Y, 2021)
"With vorinostat treatment, the best response was partial remission in 5 patients (33%) and stabilization in 4 patients (27%)."1.42Vorinostat for refractory or relapsing epidermotropic T-cell lymphoma: a retrospective cohort study of 15 patients. ( Brocard, A; Dréno, B; Knol, AC; Kogge, A; Peuvrel, L; Quéreux, G; Renaut, JJ; Saint-Jean, M; Volteau, C, 2015)
"Pruritus is one of the cardinal symptoms found in patients with leukemic cutaneous T cell lymphoma (CTCL)."1.42Improved pruritus correlates with lower levels of IL-31 in CTCL patients under different therapeutic modalities. ( Benoit, BM; Cedeno-Laurent, F; Kim, EJ; Rook, AH; Singer, EM; Vittorio, CC; Wysocka, M; Yosipovitch, G, 2015)
"Vorinostat is a potent HDAC inhibitor and has shown potential to inhibit growth of human xenograft tumors."1.39Vorinostat, an HDAC inhibitor attenuates epidermoid squamous cell carcinoma growth by dampening mTOR signaling pathway in a human xenograft murine model. ( Athar, M; Ballestas, ME; Chaudhary, SC; Elmets, CA; Kopelovich, L; Kurundkar, D; Srivastava, RK, 2013)
"Poikilodermatous mycosis fungoides is a rare form of cutaneous T-cell lymphoma that is characterized clinically by localized or diffuse patches, which consist of telangiectases, mottled hyper- and hypopigmentation, and atrophy."1.36Poikilodermatous mycosis fungoides. ( Farley-Loftus, R; Latkowski, JA; Mandal, R, 2010)

Research

Studies (55)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's15 (27.27)29.6817
2010's27 (49.09)24.3611
2020's13 (23.64)2.80

Authors

AuthorsStudies
Dehmel, F1
Ciossek, T1
Maier, T1
Weinbrenner, S1
Schmidt, B1
Zoche, M1
Beckers, T1
Fournier, JF1
Bhurruth-Alcor, Y1
Musicki, B1
Aubert, J1
Aurelly, M1
Bouix-Peter, C1
Bouquet, K1
Chantalat, L1
Delorme, M1
Drean, B1
Duvert, G1
Fleury-Bregeot, N1
Gauthier, B1
Grisendi, K1
Harris, CS1
Hennequin, LF1
Isabet, T1
Joly, F1
Lafitte, G1
Millois, C1
Morgentin, R1
Pascau, J1
Piwnica, D1
Rival, Y1
Soulet, C1
Thoreau, É1
Tomas, L1
Grimm, SE1
Witlox, W1
Wolff, R1
Chalker, A1
Hiligsmann, M1
Wijnen, B1
Ahmadu, C1
Ryder, S1
Armstrong, N1
Duffy, S1
Syndikus, I1
Kleijnen, J1
Joore, MA1
Fujii, K2
Idogawa, M1
Suzuki, N1
Iwatsuki, K2
Kanekura, T2
Hawkins, N1
Muszbek, N1
Evans, R1
Dequen-O'Byrne, P1
Jones, T1
McNamara, L1
Beylot-Barry, M2
Booken, N1
Weishaupt, C1
Scarisbrick, J2
Wu, W1
Rosen, JP1
Medley, MC1
Papadopoulou, V1
Degrauwe, N1
Decosterd, LA1
Buclin, T1
Cairoli, A1
Bordeaux, ZA1
Reddy, SV1
Lee, K1
Lu, W1
Choi, J1
Miller, M1
Roberts, C1
Pollizzi, A1
Kwatra, SG1
Kwatra, MM1
Ikumi, N1
Fujita, H2
Terui, T1
Takahashi, H1
Miura, K1
Hatta, Y1
Takei, M1
Gluud, M1
Fredholm, S1
Blümel, E1
Willerslev-Olsen, A1
Buus, TB1
Nastasi, C1
Krejsgaard, T1
Bonefeld, CM1
Woetmann, A1
Iversen, L1
Litman, T1
Geisler, C1
Ødum, N1
Lindahl, LM1
Ellis, A1
Christensen, LF1
Sharma, T1
Meyerson, H1
Kord, H1
Cooper, KD1
Gassenmaier, M1
Rentschler, M1
Fehrenbacher, B1
Eigentler, TK1
Ikenberg, K1
Kosnopfel, C1
Sinnberg, T1
Niessner, H1
Bösmüller, H1
Wagner, NB1
Schaller, M1
Garbe, C1
Röcken, M1
Porcu, P2
Hudgens, S1
Horwitz, S2
Quaglino, P1
Cowan, R1
Geskin, L2
Floden, L1
Bagot, M2
Tsianakas, A1
Moskowitz, A1
Huen, A1
Dreno, B2
Dalle, S1
Caballero, D1
Leoni, M1
Dale, S1
Herr, F1
Duvic, M5
Jimura, N1
Qiao, Z1
Tsuchiya, R1
Yoshimatsu, Y1
Kondo, T1
Basu, D1
Salgado, CM1
Bauer, B1
Hoehl, RM1
Moscinski, CN1
Schmitt, L1
Reyes-Múgica, M1
Zinzani, PL1
Kim, YH2
Moskowitz, AJ1
Dwyer, K1
Sun, W1
Herr, FM1
Ragheb, R1
Venton, G1
Chelbi, R1
Bonnet, N1
Le Treut, T1
Ivanov, V1
Mercier, C1
Poulin, P1
Beaufils, N1
Gabert, J1
Suchon, P1
Rihet, P1
Loriod, B1
Kahn-Perlès, B1
Costello, RT1
Malone, DC1
Numata, T1
Nagatani, T1
Shirai, K1
Maeda, T1
Mae, K1
Nakasu, M1
Saito, M1
Usuda, T1
Tsuboi, R2
Okubo, Y1
Wang, L2
Leite de Oliveira, R1
Huijberts, S1
Bosdriesz, E1
Pencheva, N1
Brunen, D1
Bosma, A1
Song, JY1
Zevenhoven, J1
Los-de Vries, GT1
Horlings, H1
Nuijen, B1
Beijnen, JH1
Schellens, JHM1
Bernards, R1
Kasamon, YL1
Chen, H1
de Claro, RA1
Nie, L1
Ye, J1
Blumenthal, GM1
Farrell, AT1
Pazdur, R2
Haas, NB1
Quirt, I1
Hotte, S1
McWhirter, E1
Polintan, R1
Litwin, S1
Adams, PD1
McBryan, T1
Martin, LP1
vonMehren, M1
Alpaugh, RK1
Zweibel, J1
Oza, A1
Kogge, A1
Volteau, C1
Saint-Jean, M1
Peuvrel, L1
Brocard, A1
Knol, AC1
Renaut, JJ1
Quéreux, G1
Humme, D1
Nast, A1
Erdmann, R1
Vandersee, S1
Beyer, M2
Miyagaki, T2
Sugaya, M3
Oka, T1
Sato, S1
Cedeno-Laurent, F1
Singer, EM1
Wysocka, M1
Benoit, BM1
Vittorio, CC3
Kim, EJ3
Yosipovitch, G1
Rook, AH3
Ritter, C1
Fan, K1
Paulson, KG1
Nghiem, P1
Schrama, D1
Becker, JC1
Uehara, J1
Honma, M1
Ohishi, Y1
Ishida-Yamamoto, A1
Abe, F1
Kitadate, A1
Ikeda, S1
Yamashita, J1
Nakanishi, H1
Takahashi, N1
Asaka, C1
Teshima, K1
Tagawa, H1
Moyal, L1
Yehezkel, S1
Gorovitz, B1
Keren, A1
Gilhar, A1
Lubin, I1
Sherman, S1
Hodak, E1
Klemke, CD1
Goerdt, S1
Gardner, JM2
Introcaso, CE1
Nasta, SD1
Evans, KG1
Goldstein, S1
Anderson, KA1
Bartell, HL1
Olsen, EA3
Breneman, D1
Pacheco, TR2
Parker, S2
Vonderheid, EC1
Abuav, R1
Ricker, JL2
Rizvi, S1
Chen, C2
Boileau, K1
Gunchenko, A1
Sanz-Rodriguez, C1
Geskin, LJ1
Wozniak, MB1
Villuendas, R1
Bischoff, JR1
Aparicio, CB1
Martínez Leal, JF1
de La Cueva, P1
Rodriguez, ME1
Herreros, B1
Martin-Perez, D1
Longo, MI1
Herrera, M1
Piris, MA1
Ortiz-Romero, PL1
Kavanaugh, SM1
Kavanaugh, SA1
White, LA1
Kolesar, JM1
Farley-Loftus, R1
Mandal, R1
Latkowski, JA1
Aldabagh, B1
Patel, RR1
Honda, K1
Wada, H1
Kato, Y1
Tobinai, K1
Hamada, T1
Shimamoto, T1
Noguchi, K1
Al-Yacoub, N1
Fecker, LF1
Möbs, M1
Plötz, M1
Braun, FK1
Sterry, W2
Eberle, J1
Gowda, R1
Madhunapantula, SV1
Desai, D1
Amin, S1
Robertson, GP1
Lynch, DR1
Washam, JB1
Newby, LK1
Kakizaki, A1
Fujimura, T1
Mizuashi, M1
Watabe, A1
Kambayashi, Y1
Aiba, S1
Kurundkar, D1
Srivastava, RK1
Chaudhary, SC1
Ballestas, ME1
Kopelovich, L1
Elmets, CA1
Athar, M1
Grant, S1
Easley, C1
Kirkpatrick, P1
Parker, SR1
Bradley, B1
Kuzel, TM1
Foss, FM1
Frankel, SR2
Arduino, JM1
Scheinfeld, N1
Mann, BS1
Johnson, JR1
Cohen, MH1
Justice, R1
Fantin, VR1
Loboda, A1
Paweletz, CP1
Hendrickson, RC1
Pierce, JW1
Roth, JA1
Li, L1
Gooden, F1
Korenchuk, S1
Hou, XS1
Harrington, EA1
Randolph, S1
Reilly, JF1
Ware, CM1
Kadin, ME1
Richon, VM1
Steinhoff, M1
Roewert-Huber, J1
Lukowsky, A1
Assaf, C1

Clinical Trials (5)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Phase II Study of Vorinostat in Patients With Advanced Melanoma[NCT00121225]Phase 232 participants (Actual)Interventional2005-09-30Completed
A Continuation Clinical Trial of Oral Vorinostat (MK-0683) in Advanced Cancers[NCT00907738]Phase 227 participants (Actual)Interventional2005-08-31Completed
Phase I Clinical Study of MK-0683 in Patients With Relapsed or Refractory Cutaneous T-Cell Lymphoma (CTCL)[NCT00771472]Phase 110 participants (Actual)Interventional2008-08-31Completed
Phase IIb Multicenter Clinical Trial of Oral Suberoylanilide Hydroxamic Acid (SAHA) in Advanced Cutaneous T-cell Lymphoma[NCT00091559]Phase 274 participants (Actual)Interventional2005-02-03Completed
A Phase I/II Study of Vorinostat (Zolinza®) in Combination With Capecitabine (X) and Cisplatin (P) for 1st Line Treatment of Metastatic or Recurrent Gastric Cancer[NCT01045538]Phase 1/Phase 245 participants (Actual)Interventional2010-02-28Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Comparison of VEGF Serum Levels to Response to Vorinostat

Blood specimens were collected from participants on Day 1 Cycle 1 prior to treatment (baseline), Day 1 3-4 hours following Vorinostat ingestion, Day 8 and Day 15. VEGF serum concentrations were detected using the Luminex multiplexed assay, where the median fluorescence intensity results were analyzed by a weighted five-parameter logistic method. The values were averaged across all time points per participant. (NCT00121225)
Timeframe: Baseline, Day 1, Day 8 and Day 15

Interventionpg (Mean)
Arm 1 Vorinostat203

Objective Response Rate Assessed by Response Evaluation Criteria for Solid Tumors (RECIST)

Per Response Evaluation Criteria in Solid Tumours Criteria (RECIST v1.0) for target lesions and are assessed by MRI: Complete Response (CR), disappearance of all target lesions; Partial Response (PR), at least 30% decrease in sum of longest diameter of target lesions; Objective Response (OR) = CR+ PR. (NCT00121225)
Timeframe: Up to 5 years

Interventionparticipants (Number)
Arm I2

Time to Progression Assessed by RECIST

(NCT00121225)
Timeframe: Up to 5 years

Interventionmonths (Median)
Arm 1 Vorinostat4

Difference in HP1 and MacroH2A Nuclear Foci Expression Between Progressive Minus Stable Disease Outcomes

Macro H2A and HP1 expression levels were compared through analysis of log fold changes in antibody expression in a multivariate general linear model between progressive disease and stable disease outcomes. (NCT00121225)
Timeframe: Baseline and day 15

Interventionlog fold change (Mean)
MacroH2A1.1MacroH2A1.2HP1
Arm 1 Vorinostat0.149-0.748-0.077

Number of Patients With p53 Allelic Variations (72R or 72P)

Participants were assessed for p53 allelic variation at baseline (NCT00121225)
Timeframe: Baseline

Interventionparticipants (Number)
Wild TypeMutant
Arm 1 Vorinostat2011

Percent of Participants With a Serious Drug-related Adverse Event (AE)

"A serious adverse event (SAE) was any AE occurring at any dose that resulted in death, was life-threatening, resulted in a persistent or significant disability/incapacity, resulted in or prolonged an existing inpatient hospitalization, was a congenital anomaly/birth defect, was a cancer, or was an overdose.~A drug-related SAE was one that was thought to be possibly, probably, or definitely related to the study drug." (NCT00907738)
Timeframe: From the first dose of study drug until the patient experiences disease progression, withdraws consent, or develops unacceptable toxicity (from Day 1 up to 4 years and 9 months)

Interventionpercent of participants (Number)
Base Protocol 0017.7
Base Protocol 0060
Base Protocol 0080
Base Protocol 0120
Base Protocol 0130

Part I: Number of Participants Experiencing Dose Limiting Toxicity (DLT)

"A DLT was defined as any of the following (per Common Terminology Criteria for Adverse Events [CTCAE] version 3.0):~Grade 3 (severe)-4 (life-threatening) neutropenia with fever ≥ 38.5ºC~Grade 3-4 neutropenia with an infection requiring antibiotic or antifungal treatment~Grade 4 neutropenia lasting at least 5 days~Grade 4 thrombocytopenia~Other Grade 4 hematologic toxicity, including a decrease in hemoglobin, only at the discretion of the principal investigator~Grade 3 or 4 non-hematologic event, except which are manageable by supportive care or non-prohibited therapies" (NCT00771472)
Timeframe: Day 1 to Day 28

Interventionparticipants (Number)
Vorinostat1

Part I: Maximum Drug Concentration (Cmax)

"Blood samples taken as follows:~Day 1 & Day 28 of Cycle 1: pre dose, and 0.25, 0.5, 1.0, 1.5, 2.0, 3.0, 4.0, 6.0, 8.0, 10, 12 and 24 hours after dosing of vorinostat." (NCT00771472)
Timeframe: Days 1 & 28 of Cycle 1

InterventionµM (Geometric Mean)
Day 1 (n=6)Day 28 (n=5)
Vorinostat0.831.17

Part I: The Amount of Time it Takes for the Drug Concentration to Decrease by Half (T1/2)

"Blood samples taken as follows:~Day 1 & Day 28 of Cycle 1: pre dose, and 0.25, 0.5, 1.0, 1.5, 2.0, 3.0, 4.0, 6.0, 8.0, 10, 12 and 24 hours after dosing of vorinostat." (NCT00771472)
Timeframe: Days 1 & 28 of Cycle 1

Interventionhours (Geometric Mean)
Day 1 (n=5)Day 28 (n=4)
Vorinostat1.942.30

Part I: Time at Which Cmax Occurs (Tmax)

"Blood samples taken as follows:~Day 1 & Day 28 of Cycle 1: pre dose, and 0.25, 0.5, 1.0, 1.5, 2.0, 3.0, 4.0, 6.0, 8.0, 10, 12 and 24 hours after dosing of vorinostat." (NCT00771472)
Timeframe: Days 1 & 28 of Cycle 1

Interventionhours (Median)
Day 1 (n=6)Day 28 (n=5)
Vorinostat2.913.73

Part I: Total Drug Exposure (Area Under the Concentration Curve, AUC[0-24 Hours])

"Blood samples taken as follows:~Day 1 & Day 28 of Cycle 1: pre dose, and 0.25, 0.5, 1.0, 1.5, 2.0, 3.0, 4.0, 6.0, 8.0, 10, 12 and 24 hours after dosing of vorinostat." (NCT00771472)
Timeframe: Days 1 & 28 of Cycle 1

InterventionµM*hr (Geometric Mean)
Day 1 (n=6)Day 28 (n=5)
Vorinostat4.595.59

Parts I & II: Number of Participants Experiencing Clinical or Laboratory Adverse Experiences (AE)

A laboratory AE is defined as any unfavorable & unintended change in the chemistry of the body temporally associated with the use of study product, whether or not considered related to the use of the product. A clinical AE is defined similarly but also includes changes in structure or function of the body. (NCT00771472)
Timeframe: Day 1 up until 30 days post study completion or early termination (up to approximately 506 days)

Interventionparticipants (Number)
Clinical AEsLaboratory AEs
Vorinostat106

Reviews

9 reviews available for vorinostat and Cancer of Skin

ArticleYear
Mogamulizumab for Previously Treated Mycosis Fungoides and Sézary Syndrome: An Evidence Review Group Perspective of a NICE Single Technology Appraisal.
    PharmacoEconomics, 2022, Volume: 40, Issue:5

    Topics: Adult; Antibodies, Monoclonal, Humanized; Bexarotene; Cost-Benefit Analysis; Humans; Mycosis Fungoid

2022
Systematic review of combination therapies for mycosis fungoides.
    Cancer treatment reviews, 2014, Volume: 40, Issue:8

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bexarotene; Combined Modality Therapy; Deoxycytidine

2014
Histone Deacetylase Inhibitors for Cutaneous T-Cell Lymphoma.
    Dermatologic clinics, 2015, Volume: 33, Issue:4

    Topics: Depsipeptides; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Indoles; Lymphoma, T-Cell,

2015
Molecular biology and targeted therapy of cutaneous T-cell lymphomas.
    Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia, 2008, Volume: 143, Issue:6

    Topics: Alemtuzumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Neoplasm; Antige

2008
Vorinostat: A novel therapy for the treatment of cutaneous T-cell lymphoma.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2010, May-15, Volume: 67, Issue:10

    Topics: Antineoplastic Agents; Clinical Trials as Topic; Histone Deacetylase Inhibitors; Humans; Hydroxamic

2010
QT interval prolongation and torsades de pointes in a patient undergoing treatment with vorinostat: a case report and review of the literature.
    Cardiology journal, 2012, Volume: 19, Issue:4

    Topics: Antineoplastic Agents; Doxepin; Electrocardiography; Histone Deacetylase Inhibitors; Humans; Hydroxa

2012
Treatment of cutaneous T-cell lymphoma/mycosis fungoides.
    Dermatology nursing, 2006, Volume: 18, Issue:6

    Topics: Administration, Cutaneous; Anti-Inflammatory Agents; Antineoplastic Agents; Bexarotene; Biopsy; Cost

2006
Systemic monotherapy vs combination therapy for CTCL: rationale and future strategies.
    Oncology (Williston Park, N.Y.), 2007, Volume: 21, Issue:2 Suppl 1

    Topics: Alemtuzumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Neoplasm; Antine

2007
A brief primer on treatments of cutaneous T cell lymphoma, newly approved or late in development.
    Journal of drugs in dermatology : JDD, 2007, Volume: 6, Issue:7

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Bexarotene; Diphtheria Toxin; Drug Approv

2007

Trials

10 trials available for vorinostat and Cancer of Skin

ArticleYear
Adjusting for treatment crossover in the MAVORIC trial: survival in advanced mycosis fungoides and Sézary syndrome.
    Journal of comparative effectiveness research, 2022, Volume: 11, Issue:11

    Topics: Humans; Mycosis Fungoides; Sezary Syndrome; Skin Neoplasms; Vorinostat

2022
Impact of blood involvement on efficacy and time to response with mogamulizumab in mycosis fungoides and Sézary syndrome.
    Journal of the European Academy of Dermatology and Venereology : JEADV, 2023, Volume: 37, Issue:2

    Topics: Humans; Lymphoma, T-Cell, Cutaneous; Mycosis Fungoides; Sezary Syndrome; Skin Neoplasms; Vorinostat

2023
Quality of Life Effect of the Anti-CCR4 Monoclonal Antibody Mogamulizumab Versus Vorinostat in Patients With Cutaneous T-cell Lymphoma.
    Clinical lymphoma, myeloma & leukemia, 2021, Volume: 21, Issue:2

    Topics: Aged; Antibodies, Monoclonal, Humanized; Female; Humans; Male; Middle Aged; Minimal Clinically Impor

2021
Lack of impact of type and extent of prior therapy on outcomes of mogamulizumab therapy in patients with cutaneous T cell lymphoma in the MAVORIC trial.
    Leukemia & lymphoma, 2021, Volume: 62, Issue:13

    Topics: Antibodies, Monoclonal, Humanized; Humans; Lymphoma, T-Cell, Cutaneous; Mycosis Fungoides; Sezary Sy

2021
FDA Approval Summary: Mogamulizumab-kpkc for Mycosis Fungoides and Sézary Syndrome.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2019, 12-15, Volume: 25, Issue:24

    Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal, Humanized; Drug Approval; Drug Resistance, N

2019
Phase II trial of vorinostat in advanced melanoma.
    Investigational new drugs, 2014, Volume: 32, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Biomarkers; Disease-Free Survival; Female; Fi

2014
Evaluation of the long-term tolerability and clinical benefit of vorinostat in patients with advanced cutaneous T-cell lymphoma.
    Clinical lymphoma & myeloma, 2009, Volume: 9, Issue:6

    Topics: Aged; Antineoplastic Agents; Female; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Lymph

2009
Phase I and pharmacokinetic study of the oral histone deacetylase inhibitor vorinostat in Japanese patients with relapsed or refractory cutaneous T-cell lymphoma.
    The Journal of dermatology, 2012, Volume: 39, Issue:10

    Topics: Adult; Aged; Antineoplastic Agents; Asian People; Histone Deacetylase Inhibitors; Humans; Hydroxamic

2012
Phase IIb multicenter trial of vorinostat in patients with persistent, progressive, or treatment refractory cutaneous T-cell lymphoma.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2007, Jul-20, Volume: 25, Issue:21

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Confidence Intervals; Dose-Response Relationsh

2007
FDA approval summary: vorinostat for treatment of advanced primary cutaneous T-cell lymphoma.
    The oncologist, 2007, Volume: 12, Issue:10

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Dose-Response Relations

2007

Other Studies

36 other studies available for vorinostat and Cancer of Skin

ArticleYear
Trithiocarbonates: exploration of a new head group for HDAC inhibitors.
    Bioorganic & medicinal chemistry letters, 2007, Sep-01, Volume: 17, Issue:17

    Topics: Carbon; Carbonates; Chemistry, Pharmaceutical; Drug Design; Enzyme Inhibitors; Histone Deacetylase I

2007
Squaramides as novel class I and IIB histone deacetylase inhibitors for topical treatment of cutaneous t-cell lymphoma.
    Bioorganic & medicinal chemistry letters, 2018, 09-15, Volume: 28, Issue:17

    Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Crystallography, X-Ray; Dose

2018
Functional Depletion of HSP72 by siRNA and Quercetin Enhances Vorinostat-Induced Apoptosis in an HSP72-Overexpressing Cutaneous T-Cell Lymphoma Cell Line, Hut78.
    International journal of molecular sciences, 2021, Oct-19, Volume: 22, Issue:20

    Topics: Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Resistance, Neoplasm; Drug Synergism; Gene

2021
Simultaneous kinetics of oral vorinostat in plasma and cerebrospinal fluid in a patient with cutaneous T-cell lymphoma with CNS involvement.
    International journal of clinical pharmacology and therapeutics, 2023, Volume: 61, Issue:6

    Topics: Antineoplastic Agents; Humans; Kinetics; Lymphoma, T-Cell, Cutaneous; Skin Neoplasms; Vorinostat

2023
Differential Response of Mycosis Fungoides Cells to Vorinostat.
    International journal of molecular sciences, 2023, Apr-29, Volume: 24, Issue:9

    Topics: Humans; Lymphoma, T-Cell, Cutaneous; Mycosis Fungoides; Proteomics; Skin Neoplasms; Vorinostat

2023
Aggressive CD4-CD8-CD45RA+CCR10- Primary Cutaneous Peripheral T-cell Lymphoma, Not Otherwise Specified: A Case Report.
    Acta dermato-venereologica, 2019, Nov-01, Volume: 99, Issue:12

    Topics: Aged; Antineoplastic Agents; Biomarkers, Tumor; CD4 Antigens; CD8 Antigens; Disease Progression; Fat

2019
MicroRNA-93 Targets p21 and Promotes Proliferation in Mycosis Fungoides T Cells.
    Dermatology (Basel, Switzerland), 2021, Volume: 237, Issue:2

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21;

2021
CD30
    Journal of the American Academy of Dermatology, 2021, Volume: 84, Issue:2

    Topics: Aged; Bexarotene; Humans; Ki-1 Antigen; Male; Middle Aged; Mycosis Fungoides; Photopheresis; Sezary

2021
Expression of DNA Methyltransferase 1 Is a Hallmark of Melanoma, Correlating with Proliferation and Response to B-Raf and Mitogen-Activated Protein Kinase Inhibition in Melanocytic Tumors.
    The American journal of pathology, 2020, Volume: 190, Issue:10

    Topics: Cell Line, Tumor; Cell Proliferation; DNA; Histone Deacetylase Inhibitors; Humans; Melanocytes; Mela

2020
Kinome profiling analysis identified Src pathway as a novel therapeutic target in combination with histone deacetylase inhibitors for cutaneous T-cell lymphoma.
    Journal of dermatological science, 2021, Volume: 101, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Depsipeptides; Drug Scr

2021
Histone deacetylase inhibitor Vorinostat (SAHA) suppresses micropthalmia transcription factor expression and induces cell death in nevocytes from large/giant congenital melanocytic nevi.
    Melanoma research, 2021, 08-01, Volume: 31, Issue:4

    Topics: Cell Death; Cell Differentiation; Child, Preschool; Histone Deacetylase Inhibitors; Humans; Infant;

2021
Vorinostat and Mithramycin A in combination therapy as an interesting strategy for the treatment of Sézary T lymphoma: a transcriptomic approach.
    Archives of dermatological research, 2017, Volume: 309, Issue:8

    Topics: Antineoplastic Agents; Cell Line, Tumor; Drug Therapy, Combination; Gene Expression Regulation, Neop

2017
An exploratory cost-effectiveness analysis of systemic treatments for cutaneous T-cell lymphoma.
    The Journal of dermatological treatment, 2018, Volume: 29, Issue:5

    Topics: Antineoplastic Agents; Bexarotene; Cost-Benefit Analysis; Diphtheria Toxin; Humans; Hydroxamic Acids

2018
Sézary syndrome managed with histone deacetylase inhibitor followed by anti-CCR4 monoclonal antibody.
    Clinical and experimental dermatology, 2018, Volume: 43, Issue:3

    Topics: Aged; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Histone Deacetylase Inhibitors; Huma

2018
An Acquired Vulnerability of Drug-Resistant Melanoma with Therapeutic Potential.
    Cell, 2018, 05-31, Volume: 173, Issue:6

    Topics: Amino Acid Transport System y+; Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Drug Resis

2018
Vorinostat for refractory or relapsing epidermotropic T-cell lymphoma: a retrospective cohort study of 15 patients.
    Acta dermato-venereologica, 2015, Volume: 95, Issue:1

    Topics: Adult; Aged; Antineoplastic Agents; Disease Progression; Drug Resistance, Neoplasm; Female; Histone

2015
Serum chemokine levels differentially regulated by vorinostat in a Sézary syndrome patient.
    The British journal of dermatology, 2015, Volume: 173, Issue:2

    Topics: Antineoplastic Agents; Chemokines; Female; Humans; Hydroxamic Acids; Middle Aged; Sezary Syndrome; S

2015
Improved pruritus correlates with lower levels of IL-31 in CTCL patients under different therapeutic modalities.
    Clinical immunology (Orlando, Fla.), 2015, Volume: 158, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Depsipeptides; Dexamethasone; Female; Histone Deacetylase Inhibitors

2015
Reversal of epigenetic silencing of MHC class I chain-related protein A and B improves immune recognition of Merkel cell carcinoma.
    Scientific reports, 2016, Feb-23, Volume: 6

    Topics: Acetylation; Animals; Carcinoma, Merkel Cell; Cell Line, Tumor; Cytotoxicity, Immunologic; Gene Sile

2016
Successful combination therapy of low-dose vorinostat, etretinate and narrowband ultraviolet B irradiation for Sézary syndrome.
    The Journal of dermatology, 2017, Volume: 44, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Etretinate; Female; Human

2017
Histone deacetylase inhibitors inhibit metastasis by restoring a tumor suppressive microRNA-150 in advanced cutaneous T-cell lymphoma.
    Oncotarget, 2017, Jan-31, Volume: 8, Issue:5

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Female; Gene Expression Regulation,

2017
Oncogenic role of microRNA-155 in mycosis fungoides: an in vitro and xenograft mouse model study.
    The British journal of dermatology, 2017, Volume: 177, Issue:3

    Topics: Animals; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Female; Genes, cdc; HEK293 Cells; Hete

2017
A novel regimen of vorinostat with interferon gamma for refractory Sézary syndrome.
    Journal of the American Academy of Dermatology, 2009, Volume: 61, Issue:1

    Topics: Aged, 80 and over; Combined Modality Therapy; Drug Resistance, Neoplasm; Female; Humans; Hydroxamic

2009
Vorinostat for the treatment of bullous pemphigoid in the setting of advanced, refractory cutaneous T-cell lymphoma.
    Archives of dermatology, 2009, Volume: 145, Issue:9

    Topics: Antibodies, Anti-Idiotypic; Antineoplastic Agents; Diagnosis, Differential; Dose-Response Relationsh

2009
Leukonychia related to vorinostat.
    Archives of dermatology, 2009, Volume: 145, Issue:11

    Topics: Adult; Aged; Antineoplastic Agents; Female; Follow-Up Studies; Humans; Hydroxamic Acids; Male; Mycos

2009
Vorinostat interferes with the signaling transduction pathway of T-cell receptor and synergizes with phosphoinositide-3 kinase inhibitors in cutaneous T-cell lymphoma.
    Haematologica, 2010, Volume: 95, Issue:4

    Topics: Adenosine Triphosphate; Antineoplastic Agents; Biomarkers, Tumor; Blotting, Western; Cell Proliferat

2010
Poikilodermatous mycosis fungoides.
    Dermatology online journal, 2010, Nov-15, Volume: 16, Issue:11

    Topics: Acitretin; Antineoplastic Agents; Bexarotene; Female; Humans; Hydroxamic Acids; Hypopigmentation; Im

2010
Leukemia cutis in association With Grover's disease.
    The American Journal of dermatopathology, 2011, Volume: 33, Issue:4

    Topics: Acantholysis; Aged; Antineoplastic Agents; Biopsy; Dermis; Fatal Outcome; Flavonoids; Humans; Hydrox

2011
Apoptosis induction by SAHA in cutaneous T-cell lymphoma cells is related to downregulation of c-FLIP and enhanced TRAIL signaling.
    The Journal of investigative dermatology, 2012, Volume: 132, Issue:9

    Topics: Aged; Aged, 80 and over; Antineoplastic Agents; CASP8 and FADD-Like Apoptosis Regulating Protein; Do

2012
Selenium-containing histone deacetylase inhibitors for melanoma management.
    Cancer biology & therapy, 2012, Volume: 13, Issue:9

    Topics: Anilides; Anticarcinogenic Agents; Apoptosis; Caspase 3; Caspase 7; Cell Cycle Checkpoints; Cell Lin

2012
Successful treatment of syringotropic CD8+ mycosis fungoides accompanied by hypohidrosis with vorinostat and retinoids.
    The Australasian journal of dermatology, 2013, Volume: 54, Issue:4

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; CD8 Antigens; Humans; Hydroxamic Acids; Hypoh

2013
Vorinostat, an HDAC inhibitor attenuates epidermoid squamous cell carcinoma growth by dampening mTOR signaling pathway in a human xenograft murine model.
    Toxicology and applied pharmacology, 2013, Jan-15, Volume: 266, Issue:2

    Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Squamous Cell; Cell Proliferation; Cell Surviv

2013
Vorinostat.
    Nature reviews. Drug discovery, 2007, Volume: 6, Issue:1

    Topics: Antineoplastic Agents; Clinical Trials as Topic; Clinical Trials, Phase I as Topic; Drug Approval; D

2007
Vorinostat (Zolinza) for cutaneous T-Cell lymphoma.
    The Medical letter on drugs and therapeutics, 2007, Mar-12, Volume: 49, Issue:1256

    Topics: Antineoplastic Agents; Clinical Trials as Topic; Histone Deacetylase Inhibitors; Humans; Hydroxamic

2007
Constitutive activation of signal transducers and activators of transcription predicts vorinostat resistance in cutaneous T-cell lymphoma.
    Cancer research, 2008, May-15, Volume: 68, Issue:10

    Topics: Antineoplastic Agents; Biomarkers, Tumor; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neo

2008
Complete clinical remission of tumor-stage mycosis fungoides after acute extensive skin necroses, granulomatous reaction, and fever under treatment with bexarotene, vorinostat, and high-dose fenofibrate.
    Journal of the American Academy of Dermatology, 2008, Volume: 58, Issue:5 Suppl 1

    Topics: Acute Disease; Anticarcinogenic Agents; Bexarotene; Biopsy; Drug Eruptions; Female; Fenofibrate; Fev

2008