vorinostat has been researched along with Brain Injuries in 2 studies
Vorinostat: A hydroxamic acid and anilide derivative that acts as a HISTONE DEACETYLASE inhibitor. It is used in the treatment of CUTANEOUS T-CELL LYMPHOMA and SEZARY SYNDROME.
vorinostat : A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).
Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Spontaneous intracerebral hemorrhage (ICH) is a stroke subtype with no effective treatment." | 1.43 | The Histone Deacetylase Inhibitor Suberoylanilide Hydroxamic Acid (SAHA) Confers Acute Neuroprotection After Intracerebral Hemorrhage in Mice. ( Alleyne, CH; Dhandapani, KM; Sukumari-Ramesh, S, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lu, J | 1 |
| Huang, X | 1 |
| Deng, A | 1 |
| Yao, H | 1 |
| Wu, G | 1 |
| Wang, N | 1 |
| Gui, H | 1 |
| Ren, M | 1 |
| Guo, S | 1 |
| Sukumari-Ramesh, S | 1 |
| Alleyne, CH | 1 |
| Dhandapani, KM | 1 |
2 other studies available for vorinostat and Brain Injuries
| Article | Year |
|---|---|
miR-452-3p Targets HDAC3 to Inhibit p65 Deacetylation and Activate the NF-κB Signaling Pathway in Early Brain Injury after Subarachnoid Hemorrhage.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Brain Injuries; Histone Deacetylases; Lactate Dehydrog | 2022 |
The Histone Deacetylase Inhibitor Suberoylanilide Hydroxamic Acid (SAHA) Confers Acute Neuroprotection After Intracerebral Hemorrhage in Mice.
Topics: Animals; Brain; Brain Injuries; Cerebral Hemorrhage; Disease Models, Animal; Fluoresceins; Glial Fib | 2016 |