vorinostat has been researched along with Adult Spinal Muscular Atrophy in 8 studies
Vorinostat: A hydroxamic acid and anilide derivative that acts as a HISTONE DEACETYLASE inhibitor. It is used in the treatment of CUTANEOUS T-CELL LYMPHOMA and SEZARY SYNDROME.
vorinostat : A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Proximal spinal muscular atrophy (SMA) is a common autosomal recessively inherited neuromuscular disorder determined by functional impairment of alpha-motor neurons within the spinal cord." | 1.36 | SAHA ameliorates the SMA phenotype in two mouse models for spinal muscular atrophy. ( Ackermann, B; Blumcke, I; Förster, A; Fritzsche, I; Garbes, L; Hahnen, E; Hauke, J; Jakubik, M; Mende, Y; Riessland, M; Wirth, B, 2010) |
| "Proximal spinal muscular atrophy (SMA) is a common autosomal recessively inherited neuromuscular disorder causing infant death in half of all patients." | 1.33 | The benzamide M344, a novel histone deacetylase inhibitor, significantly increases SMN2 RNA/protein levels in spinal muscular atrophy cells. ( Brichta, L; Hahnen, E; Riessland, M; Wirth, B, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 5 (62.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rietz, A | 1 |
| Li, H | 1 |
| Quist, KM | 1 |
| Cherry, JJ | 1 |
| Lorson, CL | 1 |
| Burnett, BG | 1 |
| Kern, NL | 1 |
| Calder, AN | 1 |
| Fritsche, M | 1 |
| Lusic, H | 1 |
| Boaler, PJ | 1 |
| Choi, S | 1 |
| Xing, X | 1 |
| Glicksman, MA | 1 |
| Cuny, GD | 1 |
| Androphy, EJ | 1 |
| Hodgetts, KJ | 1 |
| Lai, JI | 1 |
| Leman, LJ | 1 |
| Ku, S | 1 |
| Vickers, CJ | 1 |
| Olsen, CA | 1 |
| Montero, A | 1 |
| Ghadiri, MR | 1 |
| Gottesfeld, JM | 1 |
| Mohseni, J | 1 |
| Al-Najjar, BO | 1 |
| Wahab, HA | 1 |
| Zabidi-Hussin, ZA | 1 |
| Sasongko, TH | 1 |
| Hauke, J | 2 |
| Riessland, M | 4 |
| Lunke, S | 1 |
| Eyüpoglu, IY | 1 |
| Blümcke, I | 2 |
| El-Osta, A | 1 |
| Wirth, B | 4 |
| Hahnen, E | 3 |
| Ackermann, B | 1 |
| Förster, A | 1 |
| Jakubik, M | 1 |
| Garbes, L | 1 |
| Fritzsche, I | 1 |
| Mende, Y | 1 |
| Mutsaers, CA | 1 |
| Wishart, TM | 1 |
| Lamont, DJ | 1 |
| Schreml, J | 1 |
| Comley, LH | 1 |
| Murray, LM | 1 |
| Parson, SH | 1 |
| Lochmüller, H | 1 |
| Talbot, K | 1 |
| Gillingwater, TH | 1 |
| Kernochan, LE | 1 |
| Russo, ML | 1 |
| Woodling, NS | 1 |
| Huynh, TN | 1 |
| Avila, AM | 1 |
| Fischbeck, KH | 1 |
| Sumner, CJ | 1 |
| Brichta, L | 1 |
8 other studies available for vorinostat and Adult Spinal Muscular Atrophy
| Article | Year |
|---|---|
Discovery of a Small Molecule Probe That Post-Translationally Stabilizes the Survival Motor Neuron Protein for the Treatment of Spinal Muscular Atrophy.
Topics: Anilides; Area Under Curve; Benzamides; Cell Line; Drug Discovery; Half-Life; Humans; Isoxazoles; Mo | 2017 |
Cyclic tetrapeptide HDAC inhibitors as potential therapeutics for spinal muscular atrophy: Screening with iPSC-derived neuronal cells.
Topics: Cells, Cultured; Drug Evaluation, Preclinical; Histone Deacetylase Inhibitors; Humans; Induced Pluri | 2017 |
Transcript, methylation and molecular docking analyses of the effects of HDAC inhibitors, SAHA and Dacinostat, on SMN2 expression in fibroblasts of SMA patients.
Topics: Alternative Splicing; Cell Line; Cell Survival; Cells, Cultured; DNA Methylation; Fibroblasts; Gene | 2016 |
Survival motor neuron gene 2 silencing by DNA methylation correlates with spinal muscular atrophy disease severity and can be bypassed by histone deacetylase inhibition.
Topics: Cell Line; CpG Islands; Depsipeptides; DNA Methylation; Enzyme Inhibitors; Fibroblasts; Gene Silenci | 2009 |
SAHA ameliorates the SMA phenotype in two mouse models for spinal muscular atrophy.
Topics: Animals; Disease Models, Animal; Female; Hydroxamic Acids; Italy; Male; Mice; Mice, Knockout; Mice, | 2010 |
Reversible molecular pathology of skeletal muscle in spinal muscular atrophy.
Topics: Animals; Blotting, Western; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Immunohistoche | 2011 |
The role of histone acetylation in SMN gene expression.
Topics: Acetylation; Animals; Cells, Cultured; Chromatin Immunoprecipitation; Cyclic AMP Response Element-Bi | 2005 |
The benzamide M344, a novel histone deacetylase inhibitor, significantly increases SMN2 RNA/protein levels in spinal muscular atrophy cells.
Topics: Alternative Splicing; Blotting, Western; Cell Nucleus; Cell Survival; Cells, Cultured; Cyclic AMP Re | 2006 |