vorinostat has been researched along with Adrenoleukodystrophy in 3 studies
Vorinostat: A hydroxamic acid and anilide derivative that acts as a HISTONE DEACETYLASE inhibitor. It is used in the treatment of CUTANEOUS T-CELL LYMPHOMA and SEZARY SYNDROME.
vorinostat : A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).
Adrenoleukodystrophy: An X-linked recessive disorder characterized by the accumulation of saturated very long chain fatty acids in the LYSOSOMES of ADRENAL CORTEX and the white matter of CENTRAL NERVOUS SYSTEM. This disease occurs almost exclusively in the males. Clinical features include the childhood onset of ATAXIA; NEUROBEHAVIORAL MANIFESTATIONS; HYPERPIGMENTATION; ADRENAL INSUFFICIENCY; SEIZURES; MUSCLE SPASTICITY; and DEMENTIA. The slowly progressive adult form is called adrenomyeloneuropathy. The defective gene ABCD1 is located at Xq28, and encodes the adrenoleukodystrophy protein (ATP-BINDING CASSETTE TRANSPORTERS).
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Zierfuss, B | 1 |
| Weinhofer, I | 1 |
| Kühl, JS | 1 |
| Köhler, W | 1 |
| Bley, A | 1 |
| Zauner, K | 1 |
| Binder, J | 1 |
| Martinović, K | 1 |
| Seiser, C | 1 |
| Hertzberg, C | 1 |
| Kemp, S | 1 |
| Egger, G | 1 |
| Leitner, G | 1 |
| Bauer, J | 1 |
| Wiesinger, C | 1 |
| Kunze, M | 1 |
| Forss-Petter, S | 1 |
| Berger, J | 1 |
| Baarine, M | 1 |
| Beeson, C | 1 |
| Singh, A | 1 |
| Singh, I | 2 |
| Singh, J | 1 |
| Khan, M | 1 |
3 other studies available for vorinostat and Adrenoleukodystrophy
| Article | Year |
|---|---|
Vorinostat in the acute neuroinflammatory form of X-linked adrenoleukodystrophy.
Topics: Acute Disease; Adrenoleukodystrophy; ATP Binding Cassette Transporter, Subfamily D; ATP Binding Cass | 2020 |
ABCD1 deletion-induced mitochondrial dysfunction is corrected by SAHA: implication for adrenoleukodystrophy.
Topics: Adrenoleukodystrophy; Animals; Astrocytes; ATP Binding Cassette Transporter, Subfamily D, Member 1; | 2015 |
HDAC inhibitor SAHA normalizes the levels of VLCFAs in human skin fibroblasts from X-ALD patients and downregulates the expression of proinflammatory cytokines in Abcd1/2-silenced mouse astrocytes.
Topics: Acetylation; Acetyltransferases; Adrenoleukodystrophy; Animals; Astrocytes; ATP Binding Cassette Tra | 2011 |