vorinostat has been researched along with Acute Confusional Senile Dementia in 13 studies
Vorinostat: A hydroxamic acid and anilide derivative that acts as a HISTONE DEACETYLASE inhibitor. It is used in the treatment of CUTANEOUS T-CELL LYMPHOMA and SEZARY SYNDROME.
vorinostat : A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).
| Excerpt | Relevance | Reference |
|---|---|---|
| " In the present study, we hypothesize that a combination of an epigenetic modulator, vorinostat, along with rosiglitazone can impart improved gene expression of neurotrophic factors and attenuate biochemical and cellular alteration associated with AD mainly by loading these drugs in a surface modified nanocarrier system for enhanced bioavailability and enhanced therapeutic efficacy." | 5.62 | Neuroprotective Efficacy of Co-Encapsulated Rosiglitazone and Vorinostat Nanoparticle on Streptozotocin Induced Mice Model of Alzheimer Disease. ( Chitkara, D; Dubey, SK; K C, S; Kakoty, V; Krishna, KV; Taliyan, R, 2021) |
| "Using Alzheimer's disease and Huntington's disease as examples in the following article, some of latest data linking both the histone code and the various proteins that regulate this code to the pathogenesis of neurological disease are discussed." | 2.47 | Epigenetic treatment of neurological disease. ( Gray, SG, 2011) |
| "The pathogenesis of Alzheimer's disease (AD) has been associated with dysregulation of histone deacetylases (HDACs)." | 1.62 | Synthesis and biological evaluation of phenothiazine derivative-containing hydroxamic acids as potent class II histone deacetylase inhibitors. ( Chu, JC; Hsin, LW; Hsu, KC; Huang, WJ; Lee, HS; Lin, CH; Lin, TE; Liu, CI; Tseng, HJ; Wang, AH; Wang, HC, 2021) |
| " In the present study, we hypothesize that a combination of an epigenetic modulator, vorinostat, along with rosiglitazone can impart improved gene expression of neurotrophic factors and attenuate biochemical and cellular alteration associated with AD mainly by loading these drugs in a surface modified nanocarrier system for enhanced bioavailability and enhanced therapeutic efficacy." | 1.62 | Neuroprotective Efficacy of Co-Encapsulated Rosiglitazone and Vorinostat Nanoparticle on Streptozotocin Induced Mice Model of Alzheimer Disease. ( Chitkara, D; Dubey, SK; K C, S; Kakoty, V; Krishna, KV; Taliyan, R, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (46.15) | 24.3611 |
| 2020's | 7 (53.85) | 2.80 |
| Authors | Studies |
|---|---|
| Rabal, O | 2 |
| Sánchez-Arias, JA | 2 |
| Cuadrado-Tejedor, M | 2 |
| de Miguel, I | 2 |
| Pérez-González, M | 2 |
| García-Barroso, C | 2 |
| Ugarte, A | 2 |
| Estella-Hermoso de Mendoza, A | 2 |
| Sáez, E | 2 |
| Espelosin, M | 2 |
| Ursua, S | 2 |
| Haizhong, T | 2 |
| Wei, W | 2 |
| Musheng, X | 2 |
| Garcia-Osta, A | 2 |
| Oyarzabal, J | 2 |
| Hu, J | 1 |
| An, B | 1 |
| Pan, T | 1 |
| Li, Z | 1 |
| Huang, L | 1 |
| Li, X | 1 |
| Tseng, HJ | 2 |
| Lin, MH | 1 |
| Shiao, YJ | 1 |
| Yang, YC | 1 |
| Chu, JC | 2 |
| Chen, CY | 1 |
| Chen, YY | 1 |
| Lin, TE | 2 |
| Su, CJ | 1 |
| Pan, SL | 1 |
| Chen, LC | 1 |
| Wang, CY | 1 |
| Hsu, KC | 2 |
| Huang, WJ | 2 |
| De Simone, A | 1 |
| Tumiatti, V | 1 |
| Andrisano, V | 1 |
| Milelli, A | 1 |
| Liu, CI | 1 |
| Wang, HC | 1 |
| Lee, HS | 1 |
| Hsin, LW | 1 |
| Wang, AH | 1 |
| Lin, CH | 1 |
| Li, Y | 1 |
| Sang, S | 1 |
| Ren, W | 1 |
| Pei, Y | 1 |
| Bian, Y | 1 |
| Chen, Y | 1 |
| Sun, H | 1 |
| Athaide Rocha, KM | 1 |
| Machado, FR | 1 |
| Poetini, M | 1 |
| Giacomeli, R | 1 |
| Boeira, SP | 1 |
| Jesse, CR | 1 |
| Gomes de Gomes, M | 1 |
| Fan, C | 1 |
| Chen, K | 1 |
| Zhou, J | 1 |
| Wong, PP | 1 |
| He, D | 1 |
| Huang, Y | 1 |
| Wang, X | 1 |
| Ling, T | 1 |
| Yang, Y | 1 |
| Zhao, H | 1 |
| K C, S | 1 |
| Kakoty, V | 1 |
| Krishna, KV | 1 |
| Dubey, SK | 1 |
| Chitkara, D | 1 |
| Taliyan, R | 1 |
| Rustenhoven, J | 1 |
| Smith, AM | 1 |
| Smyth, LC | 1 |
| Jansson, D | 1 |
| Scotter, EL | 1 |
| Swanson, MEV | 1 |
| Aalderink, M | 1 |
| Coppieters, N | 1 |
| Narayan, P | 1 |
| Handley, R | 1 |
| Overall, C | 1 |
| Park, TIH | 1 |
| Schweder, P | 1 |
| Heppner, P | 1 |
| Curtis, MA | 1 |
| Faull, RLM | 1 |
| Dragunow, M | 1 |
| Benito, E | 1 |
| Urbanke, H | 1 |
| Ramachandran, B | 1 |
| Barth, J | 1 |
| Halder, R | 1 |
| Awasthi, A | 1 |
| Jain, G | 1 |
| Capece, V | 1 |
| Burkhardt, S | 1 |
| Navarro-Sala, M | 1 |
| Nagarajan, S | 1 |
| Schütz, AL | 1 |
| Johnsen, SA | 1 |
| Bonn, S | 1 |
| Lührmann, R | 1 |
| Dean, C | 1 |
| Fischer, A | 1 |
| Gray, SG | 1 |
2 reviews available for vorinostat and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
Inhibition of Histone Deacetylase 6 (HDAC6) as a therapeutic strategy for Alzheimer's disease: A review (2010-2020).
Topics: Acetamides; Alzheimer Disease; Histone Deacetylase 6; Histone Deacetylase Inhibitors; Humans; Hydrox | 2021 |
Epigenetic treatment of neurological disease.
Topics: Alzheimer Disease; Butylamines; Cell Differentiation; Endoplasmic Reticulum Stress; Epigenesis, Gene | 2011 |
11 other studies available for vorinostat and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
Design, Synthesis, and Biological Evaluation of First-in-Class Dual Acting Histone Deacetylases (HDACs) and Phosphodiesterase 5 (PDE5) Inhibitors for the Treatment of Alzheimer's Disease.
Topics: Acetylation; Alzheimer Disease; Animals; Cell Line; Cells, Cultured; Cyclic AMP Response Element-Bin | 2016 |
Design, synthesis, biological evaluation and in vivo testing of dual phosphodiesterase 5 (PDE5) and histone deacetylase 6 (HDAC6)-selective inhibitors for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Cell Line; Cyclic Nucleotide Phosphodiesterases, Type 5; Dose-Response Relationsh | 2018 |
Design, synthesis, and biological evaluation of histone deacetylase inhibitors possessing glutathione peroxidase-like and antioxidant activities against Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Azoles; Biomimetic Materials; Drug Design; Free Radical Scavengers; Glut | 2018 |
Synthesis and biological evaluation of acridine-based histone deacetylase inhibitors as multitarget agents against Alzheimer's disease.
Topics: Acetylcholinesterase; Acridines; Alzheimer Disease; Amyloid beta-Peptides; Animals; Cell Survival; C | 2020 |
Glycogen Synthase Kinase 3β: A New Gold Rush in Anti-Alzheimer's Disease Multitarget Drug Discovery?
Topics: Alzheimer Disease; Drug Discovery; Glycogen Synthase Kinase 3 beta; Humans; Phosphorylation | 2021 |
Synthesis and biological evaluation of phenothiazine derivative-containing hydroxamic acids as potent class II histone deacetylase inhibitors.
Topics: Acetylation; Alzheimer Disease; Binding Sites; Blood-Brain Barrier; Cell Line, Tumor; Cell Survival; | 2021 |
Assessment of suberoylanilide hydroxamic acid on a Alzheimer's disease model induced by β-amyloid
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain-Derived Neurotrophic Factor; Epigenesis, Ge | 2023 |
Systematic analysis to identify transcriptome-wide dysregulation of Alzheimer's disease in genes and isoforms.
Topics: Alternative Splicing; Alzheimer Disease; Datasets as Topic; Female; Gene Expression Regulation; Gene | 2021 |
Neuroprotective Efficacy of Co-Encapsulated Rosiglitazone and Vorinostat Nanoparticle on Streptozotocin Induced Mice Model of Alzheimer Disease.
Topics: Alzheimer Disease; Animals; Mice; Nanoparticles; PPAR gamma; Rosiglitazone; Streptozocin; Thiazolidi | 2021 |
PU.1 regulates Alzheimer's disease-associated genes in primary human microglia.
Topics: Alzheimer Disease; Gene Expression Regulation; Histone Deacetylase Inhibitors; Humans; Microglia; Pr | 2018 |
HDAC inhibitor-dependent transcriptome and memory reinstatement in cognitive decline models.
Topics: Acetylation; Aging; Alzheimer Disease; Amyloid; Animals; CA1 Region, Hippocampal; Disease Models, An | 2015 |