vivit-peptide and Hyperglycemia

vivit-peptide has been researched along with Hyperglycemia* in 1 studies

Other Studies

1 other study(ies) available for vivit-peptide and Hyperglycemia

Article	Year
[NFAT2 mediates high glucose-induced apoptosis in glomerular podocytes Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2018, Sep-30, Volume: 38, Issue:10 To determine whether hyperglycemia activates NFAT2 in cultured podocytes to cause podocyte apoptosis and explore the role of NFAT2 in high glucose-induced podocyte apoptosis.. Exposure to high glucose in the medium time- and dose-dependently activated NFAT2 in cultured podocytes. Pretreatment with cyclosporine A or 11R- VIVIT completely blocked nuclear accumulation of NFAT2. Treatment with 11R- vivit also inhibited high glucoseinduced apoptosis in cultured podocytes. Exposure to high glucose obviously increased [Ca. High glucose-induced apoptosis in podocytes is mediated by calcineurin/NFAT2/Bax signaling pathway, which may serve as a potential target for therapeutic intervention. Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Calcineurin; Cells, Cultured; Cyclosporine; Glucose; Hyperglycemia; Mice; NFATC Transcription Factors; Oligopeptides; Podocytes; Signal Transduction	2018

Article

Year

[NFAT2 mediates high glucose-induced apoptosis in glomerular podocytes

Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2018, Sep-30, Volume: 38, Issue:10

To determine whether hyperglycemia activates NFAT2 in cultured podocytes to cause podocyte apoptosis and explore the role of NFAT2 in high glucose-induced podocyte apoptosis.. Exposure to high glucose in the medium time- and dose-dependently activated NFAT2 in cultured podocytes. Pretreatment with cyclosporine A or 11R- VIVIT completely blocked nuclear accumulation of NFAT2. Treatment with 11R- vivit also inhibited high glucoseinduced apoptosis in cultured podocytes. Exposure to high glucose obviously increased [Ca. High glucose-induced apoptosis in podocytes is mediated by calcineurin/NFAT2/Bax signaling pathway, which may serve as a potential target for therapeutic intervention.

Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Calcineurin; Cells, Cultured; Cyclosporine; Glucose; Hyperglycemia; Mice; NFATC Transcription Factors; Oligopeptides; Podocytes; Signal Transduction

2018