vitamin-u and Stomach-Ulcer

Four groups of about 86 pigs from a common source were fed a grower diet from 25 kg to 45 kg liveweight, and then from 45 to 107 kg liveweight they were offered one of four diets ad libitum: A) normal commercial feed, ground through a 3 mm screen (the control diet), B) the same diet ground through a 6 mm screen, C) the control diet to which lucerne meal was added before the diet was ground to increase its crude fibre content, and D) the control diet to which was added 400 ppm S-methylmethionine-sulphonium chloride (MMSC). All the diets were pelleted. Approximately 21 per cent of the animals fed the control diet had severe oesophagogastric erosions and/or ulcers after slaughter. The addition of 400 ppm MMSC decreased (P = 0.066) the proportion of severe oesophagogastric erosions and/or ulcers by about 50 per cent compared with the control diet. The diet with the higher crude fibre content (but finely ground) did not have a significant effect on the proportion of severe oesophagogastric erosions and/or ulcers. There was a tendency for the pigs fed the diet ground through a 6 mm screen instead of a 3 mm screen, to have fewer severe oesophagogastric erosions and/or ulcers. However, there were only small differences between the particle size distribution obtained from the wet sieve analysis of the two diets. As a result, the observed tendency for a decrease in the proportion of severe oesophagogastric erosions and/or ulcers in pigs fed the diet milled through the larger screen size was of questionable significance.(ABSTRACT TRUNCATED AT 250 WORDS)

Topics: Animal Feed; Animals; Dietary Fiber; Esophageal Diseases; Stomach Ulcer; Swine; Swine Diseases; Ulcer; Vitamin U

To assess the value of s-methylmethionine sulphonium chloride (SMMSC) (200 mg/kg) on nutritional performance of pigs and as prevention or therapy for oesophagogastric ulcers.. Sixty pigs from a high health status herd with continuing oesophagogastric ulcer problems were endoscopically assessed for the presence or absence of oesophagogastric ulcers. Forty-eight pigs were then selected and allocated according to an initial oesophagogastric epithelial (ulcer score) classification to replicated treatment groups in a 2 x 2 factorial design. Weight gain and feed intake were measured over 49 d, after which pigs were killed and stomachs were collected, re-examined and scored for oesophagogastric ulceration.. There was no difference over the 49 d in weight gain, feed intake and backfat in pigs with and without SMMSC supplementation between pigs with or without fully developed oesophagogastric ulcers at the start of the study. In pigs with an initially low ulcer score, feeding SMMSC did not prevent further oesophagogastric ulcer development. No significant effect of SMMSC was apparent when final mean oesophagogastric ulcer scores were compared in pigs with existing high ulcer score. However, further analysis of the changes in individual pig oesophagogastric ulcer scores during the experiment showed that the observed reductions in scores of the high ulcer group was significantly different from all other groups.. This study has indicated that supplementation of pig diets with SMMSC cannot be justified unless the slight ulcer score improvement observed could be translated to some commercial production advantage such as a reduction in pig mortalities due to oesophagogastric ulcers. This study has further confirmed the benefit of endoscopy as a tool to enable objective assessment of oesophageal gastric health.

Topics: Animal Feed; Animals; Anti-Ulcer Agents; Esophageal Diseases; Severity of Illness Index; Stomach Ulcer; Sulfonium Compounds; Swine; Swine Diseases; Treatment Outcome; Vitamin U; Weight Gain

Reserpine (intraperitoneal, 5 mg/kg every day for 5 days) produced chronic ulceration of the rat stomach 2 weeks postdose. Gavage with 1% DL-cysteine or DL-methionine-S-methylsulfonium chloride at 1 mL/day for 2 weeks and 5 days protected against ulceration in 30% of the rats, and this protection extended to 80% of cases with 2% solutions. Similar gavage with 5% solutions protected all rats against ulceration without significantly influencing the basal H+ output [13.1 +/- 0.3 and 14.2 +/- 0.2 mumol for DL-cysteine and DL-methionine-S-methylsulfonium chloride, respectively, versus 15.1 +/- 0.4 mumol (mean +/- standard error of the mean; n = 10)]; that is, cytoprotection was achieved.

Topics: Animals; Cysteine; Female; Male; Rats; Rats, Inbred Strains; Reserpine; Stomach Ulcer; Vitamin U

One milliliter of 1, 2, or 5% DL-cysteine (cysteine) or DL-methionine methylsulfonium chloride (MMSC) was instilled into the rat stomach 1, 24, and 48 h after giving ethanol (1 mL of 40% solution) by gavage. One hour following the administration of ethanol, gastric mucosal injury was seen in all the animals (22.6 +/- 1.1 mm2, mean +/- SEM; n = 10). Twenty-four hours after giving the ethanol, all the rats treated with cysteine or MMSC still had the mucosal injury. Treatment with 2% cysteine or MMSC significantly (p less than 0.01) reduced the extent of this injury (10.2 +/- 0.6 and 10.1 +/- 0.5 mm2, respectively, versus 20.7 +/- 1.2 mm2, mean +/- SEM; n = 10), an action that was similarly achieved by the 5% solutions (10.1 +/- 0.5 and 9.9 +/- 0.3 mm2, respectively, versus 20.7 +/- 1.2 mm2, mean +/- SEM; n = 10). Forty-eight hours following the administration of ethanol, 30% of the animals given 1% cysteine or MMSC still had gastric mucosal injury, which was significantly (p less than 0.001) less extensive than that seen with ethanol alone (3.8 +/- 0.3 and 4.1 +/- 0.3 mm2, respectively, versus 13.1 +/- 0.8 mm2, mean +/- SEM; n = 10). At this time period, however, none of the animals treated with 2 or 5% solutions of cysteine or MMSC still had any injury. Healing of the ethanol-induced injury was confirmed microscopically and was achieved by regeneration.(ABSTRACT TRUNCATED AT 250 WORDS)

Topics: Animals; Cysteine; Dose-Response Relationship, Drug; Ethanol; Female; Gastric Mucosa; Gastritis; Male; Rats; Rats, Inbred Strains; Reserpine; Stomach Ulcer; Vitamin U

Topics: Anti-Ulcer Agents; Duodenal Ulcer; Female; Humans; Male; Plant Oils; Stomach Ulcer; Vitamin U; Vitamins

Topics: Animals; Esophageal Diseases; Stomach Ulcer; Swine; Swine Diseases; Vitamin U; Vitamins

Topics: Animals; Esophageal Diseases; Stomach Ulcer; Swine; Swine Diseases; Vitamin U; Vitamins

Topics: Animals; Gastric Juice; Guanidines; Guinea Pigs; Histamine H2 Antagonists; Mice; Panax; Plants, Medicinal; Rats; Saponins; Stomach Ulcer; Vitamin U

Topics: Animals; Avitaminosis; Cross-Sectional Studies; Esophageal Diseases; Esophagogastric Junction; Hungary; Stomach Ulcer; Swine; Swine Diseases; Vitamin U

Topics: Animals; Esophageal Diseases; Esophagogastric Junction; Stomach Ulcer; Swine; Swine Diseases; Vitamin U; Vitamins

Topics: Adult; Chronic Disease; Drug Evaluation; Drug Therapy, Combination; Duodenal Ulcer; Female; Gastric Mucosa; Humans; Male; Middle Aged; Peptic Ulcer; Stomach Ulcer; Time Factors; Vitamin U; Vitamins

Topics: Disease Management; Humans; Peptic Ulcer; Stomach Ulcer; Vitamin A; Vitamin K; Vitamin U; Vitamins