vitamin-u and Hyperlipidemias

The hypolipidemic and anti-atheromatous effect of S-methylmethionine sulfonium chloride (Vitamin U, MMSC) were investigated using various experimental procedures. In the results, orally administered MMSC markedly normalized dietary-induced hyperlipidemia in rats and rabbits, demonstrating the lowering effects on plasma total cholesterol, beta-lipoprotein and phospholipids, and no appreciable effect on plasma triglycerides. In normolipidemic and a surfactant-induced hyperlipidemic rats, MMSC did not decrease plasma lipids level, nor MMSC-affected plasma lipoprotein lipase and liver catalase activities. In contrast, clofibrate showed little or no effect on plasma lipids level of dietary-induced hyperlipidemic rats, with exception of plasma triglycerides, whereas clofibrate lowered plasma lipids level in normolipidemic and surfactant-induced hyperlipidemic rats, and enhanced liver catalase activity. From the results, the lipids lowering effects of MMSC using various procedures were clearly differentiated from those of clofibrate. Additionally, the anti-atheromatous effect of MMSC was histopathologically demonstrated in dietary-induced ahteromatous rabbits. A unique hypolipidemic effect of MMSC is discussed from therapeutic viewpoint.

Topics: Animals; Catalase; Clofibrate; Diet; Hyperlipidemias; Hypolipidemic Agents; Lipoprotein Lipase; Liver; Male; Rabbits; Rats; Sex Factors; Species Specificity; Vitamin U; Vitamins

The effects of S-methylmethionine sulfonium chloride (MMSC, vitamin U) on aminonucleoside-induced nephrotic hyperlipidemia in rats were investigated. We found that repeated oral administration of MMSC (dose: daily 1000 mg/kg) exhibited significant amelioration of plasma chloresterol and phospholipids levels. Also, the treatment improved nephrotic syndrome itself by producing an increase of urinary volume and a decrease of urinary protein excretion. The results suggest that MMSC may be useful as single or combined therapy for human nephrotic syndrome and its related hyperlipidemia as a safety drug.

Topics: Animals; Body Weight; Cholesterol; Drinking Behavior; Feeding Behavior; Hyperlipidemias; Male; Nephrosis; Organ Size; Phospholipids; Purine Nucleosides; Rats; Vitamin U; Vitamins

Hypolipidemic effects of S-methylmethionine (MMSC) were compared with clofibrate in 3 experimental procedures. In results, the characteristic effect of MMSC is discussed from therapeutic viewpoint.

Topics: Animals; Cholesterol; Clofibrate; Dietary Fats; Hyperlipidemias; Lipid Metabolism; Lipids; Rabbits; Rats; Vitamin U; Vitamins