vitamin-u and Duodenal-Ulcer

This prospective randomized double-blind study examined whether sulphydryl-containing agents stimulate the healing and prevent the recurrence of duodenal ulceration in man. To this end, DL-methionine methyl sulphonium chloride (MMSC, 500 mg four times daily) or DL-cysteine (200 mg four times daily) were orally administered with cimetidine. Symptomatic endoscopy-proven duodenal ulcer patients who were smokers and social drinkers were randomized to receive for 8 weeks cimetidine (400 mg b.d.), cimetidine (400 mg b.d.) with MMSC, or cimetidine (400 mg b.d.) with cysteine. These patients were then kept on their respective oral regimens (except for cimetidine which was changed to 400 mg at bedtime) for 1 year (maintenance) and followed up for another. After 8 weeks of treatment, the ulceration healed in 65 patients (74%) given cimetidine alone but in all the patients given MMSC (n = 87) or cysteine (n = 86) with cimetidine (p less than 0.01). During the maintenance year, 15 patients (29%) given cimetidine at night relapsed. Addition of MMSC or cysteine to cimetidine incurred a significantly (p less than 0.001) lower relapse rate. During the year following maintenance therapy, the relapse rate in the group that had been previously treated with cimetidine alone (63%, n = 51) was significantly (p less than 0.001) higher than that in the groups previously treated with MMSC and cimetidine (6%, n = 67) or cysteine with cimetidine (6%, n = 64). The results suggest that sulphydryl-containing agents stimulate the healing and protect against the recurrence of duodenal ulceration.

Topics: Adolescent; Adult; Aged; Cimetidine; Cysteine; Double-Blind Method; Drug Therapy, Combination; Duodenal Ulcer; Female; Humans; Male; Middle Aged; Prospective Studies; Recurrence; Sulfhydryl Compounds; Vitamin U; Wound Healing

This study employed the oxygen-derived free radical removing agents DL-cysteine, methyl-methionine sulfonium bromide (MMSB), dimethyl sulfoxide (DMSO), and allopurinol to examine the role of oxyradicals in the mechanism of acute and chronic duodenal ulceration in the rat. These agents were administered by gavage under light ether anesthesia. All rats infused subcutaneously for 24 hr with pentagastrin (4 micrograms/kg/min) and carbachol (0.8 microgram/kg/min) developed acute duodenal ulceration and hyperchlorhydria (68 +/- 6.1 mumol vs 12.5 +/- 0.3 mumol, mean +/- SEM, N = 10, P less than 0.001). Pretreatment with DL-cysteine, MMSB, DMSO, or allopurinol provided dose-dependent protection against this ulceration without significantly influencing the hyperchlorhydria. One percent solutions of these agents protected at least 20% of rats against ulceration. Five or 10% solutions of DL-cysteine, MMSB, or DMSO protected at least 70% of rats against ulceration and similar concentrations of allopurinol protected all animals. All rats having intramuscular reserpine (0.1 mg/kg) every day for six weeks developed chronic duodenal ulceration and hyperchlorhydria (52 +/- 3.1 mumol vs 13.1 +/- 0.7 mumol, mean +/- SEM, N = 10, P less than 0.001). Pretreatment with DL-cysteine, MMSB, DMSO, or allopurinol achieved dose-dependent protection against ulceration without significantly influencing the hyperchlorhydria. One percent solutions of DL-cysteine, MMSB, or DMSO protected at least 60% of rats against ulceration; however, a similar concentration of allopurinol protected 80% of animals. Five or 10% solutions of DL-cysteine, MMSB, or DMSO protected at least 80% of rats against ulceration and similar concentrations of allopurinol protected all rats.(ABSTRACT TRUNCATED AT 250 WORDS)

Topics: Allopurinol; Animals; Cysteine; Dimethyl Sulfoxide; Duodenal Ulcer; Female; Free Radicals; Male; Oxygen; Rats; Rats, Inbred Strains; Vitamin U

Topics: Anti-Ulcer Agents; Duodenal Ulcer; Female; Humans; Male; Plant Oils; Stomach Ulcer; Vitamin U; Vitamins

Topics: Adult; Chronic Disease; Drug Evaluation; Drug Therapy, Combination; Duodenal Ulcer; Female; Gastric Mucosa; Humans; Male; Middle Aged; Peptic Ulcer; Stomach Ulcer; Time Factors; Vitamin U; Vitamins