vitamin-u and Body-Weight

The insulinomimetic activity of a Zn(ii) complex is reported. The effects of the Zn(ii) complex with ascorbic acid (Vitamin C; VC), methylmethionine sulfonium chloride (Vitamin U; VU) and l-carnitine were assessed in diet-induced metabolic syndrome model rats. Zn(VU)(2)Cl(2) and Zn(VC)Cl(2) were suggested to be useful supplementary materials for preventing metabolic syndrome by reducing visceral adipose tissues or accelerating blood fluidity.

Topics: Adipocytes; Adipose Tissue; Animals; Ascorbic Acid; Body Weight; Carnitine; Cell Separation; Diet; Disease Models, Animal; Fatty Acids; Feeding Behavior; Glucose; Inhibitory Concentration 50; Insulin; Metabolic Syndrome; Rats; Vitamin U; Zinc

The effect of L-form S-methylmethionine sulfonium chloride (L-MMSC) was studied in 26 patients with hypercholesterolemia during the oral administration period for 8 weeks (daily dose 1500 mg). The oral administration of L-MMSC resulted in the statistically significant decrease of serum total cholesterol (9.7%, P less than 0.001), but not of serum triglycerides. In addition, the statistically significant increases in serum high-density lipoprotein-cholesterol (HDL-cholesterol) and in the ratios of HDL-cholesterol/(total cholesterol) -- (HDL-cholesterol) and HDL-cholesterol/(total cholesterol) + (triglycerides) were observed by the administration of L-MMSC. The therapeutic effects in in-patients were more remarkable than those in outpatients.

Topics: Adult; Body Weight; Cholesterol; Female; Humans; Hypolipidemic Agents; Lipoproteins, HDL; Male; Middle Aged; Triglycerides; Vitamin U; Vitamins

A pharmacological difference between S-methylmethionine (MMSC) and methionine (Met) at higher dose p.o. was tested on the fatty liver in choline-deficient rats. MMSC normalized the fatty liver. In contrast, Met accelerated the syndrome accompanying with increased liver weight.

Topics: Animals; Body Weight; Choline Deficiency; Diet; Fatty Liver; Male; Methionine; Organ Size; Rats; Time Factors; Vitamin U; Vitamins

Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Female; Fetal Diseases; Glucosinolates; Kidney; Lethal Dose 50; Liver; Male; Organ Size; Pregnancy; Rats; Thioglycosides; Thyroid Gland; Vitamin U; Vitamins

The effects of S-methylmethionine sulfonium chloride (MMSC, vitamin U) on aminonucleoside-induced nephrotic hyperlipidemia in rats were investigated. We found that repeated oral administration of MMSC (dose: daily 1000 mg/kg) exhibited significant amelioration of plasma chloresterol and phospholipids levels. Also, the treatment improved nephrotic syndrome itself by producing an increase of urinary volume and a decrease of urinary protein excretion. The results suggest that MMSC may be useful as single or combined therapy for human nephrotic syndrome and its related hyperlipidemia as a safety drug.

Topics: Animals; Body Weight; Cholesterol; Drinking Behavior; Feeding Behavior; Hyperlipidemias; Male; Nephrosis; Organ Size; Phospholipids; Purine Nucleosides; Rats; Vitamin U; Vitamins