vitamin-k-semiquinone-radical and von-Willebrand-Diseases

Our understanding of haemostatic mechanisms has increased in the last decades. This knowledge at the cellular and molecular levels has helped us to appreciate the complexity of haemostatic mechanisms and their disturbance in various disorders. The advance in techniques to measure early activation of coagulation and platelets opens hope of treating acquired bleeding disorders e.g., disseminated intravascular coagulation before the full blown picture. More study needs to be done to define what constitutes normal haemostasis in newborns. The better understanding of control mechanisms of haemostasis will help us in diagnosis and treatment.

Topics: Antithrombin III; Blood Coagulation; Blood Coagulation Disorders; Blood Coagulation Factors; Blood Platelet Disorders; Blood Platelets; Blood Vessels; Child; Factor VIII; Fibrinolysis; Glycoproteins; Hemophilia A; Hemostasis; Humans; Infant, Newborn; Platelet Storage Pool Deficiency; Prostaglandins; Protein C; Vitamin K; von Willebrand Diseases; von Willebrand Factor

Topics: Afibrinogenemia; Antigens; Blood Coagulation; Blood Coagulation Disorders; Blood Coagulation Factors; Blood Sedimentation; Blood Transfusion; Factor VII Deficiency; Factor XIII Deficiency; Fibrinogen; Hemophilia A; Hemophilia B; Humans; Vitamin K; von Willebrand Diseases

Topics: Asphyxia Neonatorum; Autoantibodies; Blood Coagulation Tests; Blood Platelets; Blood Transfusion; Capillary Fragility; Capillary Permeability; Cerebral Hemorrhage; Disseminated Intravascular Coagulation; Exchange Transfusion, Whole Blood; Female; Hemophilia A; Hemorrhage; Hemorrhagic Disorders; Heparin; Humans; Infant, Newborn; Infant, Newborn, Diseases; Lung; Maternal-Fetal Exchange; Pregnancy; Thrombocytopenia; Vitamin K; Vitamin K Deficiency; von Willebrand Diseases

Topics: Ascorbic Acid; Blood Transfusion; Female; Humans; Infant; Vitamin K; von Willebrand Diseases