vitamin-k-semiquinone-radical and Respiratory-Insufficiency

The objectives of this retrospective cohort study were to examine the effect of vitamin K administration on hemorrhagic and thrombotic complications, blood product utilization, and outcomes in neonatal extracorporeal membrane oxygenation (ECMO).. In the pilot study, complications, blood product use, and outcome data for neonates who received (. In the pilot study, vitamin K at ECMO initiation was associated with fewer thrombotic complications and similar hemorrhagic complications. The volume of fresh frozen plasma was higher in neonates who received vitamin K, but total blood product and other component volume did not differ between groups. ECMO run time, survival off ECMO, survival to discharge, and length of stay did not differ between cohorts. In the validation cohort, neonates who received additional vitamin K during ECMO had longer ECMO run time and length of stay, but no difference in mortality was observed. Further, thrombotic and hemorrhagic complications as well as blood product exposure were similar between cohorts.. These data suggest that routine vitamin K administration may have limited or no benefit during neonatal ECMO.

Topics: Extracorporeal Membrane Oxygenation; Humans; Hypoxia; Infant, Newborn; Pilot Projects; Respiratory Insufficiency; Retrospective Studies; Thrombosis; Treatment Outcome; Vitamin K

Antiphospholipid syndrome associate thromboembolic events (arterial or venous), and presence of antiphospholipid antibodies, and require anticoagulation. A catastrophic variant may develop, resulting in multiorgan failure, with high mortality rate. This article presented a patient with antiphospholipid syndrome presenting a catastrophic antiphospholipide syndrome after anticoagulation suspending for gastrointestinal bleeding. Multidisciplinary management in intensive care unit and aggressive therapies (corticosteroids, anticoagulation, plasma exchange) were essential to rescue the patient.

Topics: Anemia; Anticoagulants; Antiphospholipid Syndrome; Biopsy; Catastrophic Illness; Gastrointestinal Hemorrhage; Hemoglobins; Hemostatics; Heparin; Humans; Male; Middle Aged; Platelet Count; Respiratory Insufficiency; Vitamin K

Topics: Analgesics; Analgesics, Non-Narcotic; Anticoagulants; Antipyretics; Atropine; Bandages; Citrates; Dexamethasone; Diuretics; Endopeptidases; Germany; Germany, West; Khellin; Lactates; Muscle Relaxants, Central; Phenytoin; Plants, Medicinal; Prednisolone; Respiratory Insufficiency; Sulfonamides; Suppositories; Tartrates; Theophylline; Vitamin K; Vitamins