vitamin-k-semiquinone-radical and Postpartum-Hemorrhage

Topics: Abnormalities, Drug-Induced; Anticoagulants; Blood Coagulation Disorders; Blood Coagulation Factors; Coumarins; Embolism; Female; Fetus; Heart Valve Prosthesis; Hemorrhage; Heparin; Humans; Infant, Newborn; Maternal-Fetal Exchange; Postpartum Hemorrhage; Pregnancy; Pregnancy Complications, Cardiovascular; Thrombophlebitis; Uterus; Vitamin K

Guidelines for women with epilepsy (WWE) are advising those on enzyme inducing drugs EIAEDs to take vitamin K the last month of pregnancy. The primary aim of this study was to investigate whether WWE have a higher frequency of large post partum hemorrhage. Secondary we wanted to see if this was more severe in women taking EIAEDs, and also to evaluate whether those receiving prenatal vitamin K supplementation have a less pronounced risk.. All patients (n=109), with the diagnosis of epilepsy giving birth at OUS Rikshospitalet from 2006 to 2011 were selected to be in the epilepsy group. They were compared to controls with regard to the amount of post partum hemorrhage, gestational age for the mother, birth weight and APGAR score in the newborns.. No significant difference between the groups regarding post partum hemorrhage, gestational age, birthweight or APGAR score in the newborn was found. Also, comparing the WWE using EIAED who received prenatal vitamin K with those who did not receive vitamin K, no significant difference in post partum hemorrhage could be demonstrated.. In this study, WWE was not found to have increased risk of post partum hemmorrhage including those using EIAED with/without vitamin K supplementation.

Topics: Anticonvulsants; Dietary Supplements; Epilepsy; Female; Humans; Infant; Male; Postpartum Hemorrhage; Pregnancy; Pregnancy Complications; Retrospective Studies; Treatment Outcome; Vitamin K

Pregnancies and deliveries represent important hemostatic challenges for congenital coagulation disorders. The same is true for the assumption of oral contraceptives. Available information mainly deals with von Willebrand's disease, factor XI (FXI) deficiency and carriers of hemophilia A. Data concerning patients with congenital prothrombin complex factor deficiencies are very scanty. In the present study, data of a total of 27 women are presented, 11 patients with homozygous or double heterozygous deficiencies of FII, FVII and FX, together with 16 cases of hemophilia B carriers. The patients with FII, FVII or FX defects had a total of 14 pregnancies and often needed transfusion therapy. Proper management resulted in a decrease in postpartum bleeding and satisfactory fetal outcome. Elective cesarean delivery seems indicated only in recent years. Carriers of hemophilia B had a total of 19 pregnancies but showed no bleeding and needed no substitutive therapy. Searching the literature, we discovered only 9 additional patients with prothrombin deficiency or FX deficiency, having a total of 16 pregnancies. On the contrary, there were at least 17 additional patients with FVII deficiency, with a total of 21 pregnancies. The management of the diseases has been variable, but in substantial agreement with the personal observations. Oral contraceptive therapy was administered in some of our patients and in a few additional cases described in the literature. Medication was always well tolerated and patients who took it for a long period of time showed a decrease in menometrorrhagia and an improvement in hematocrit levels. This led to a decrease in transfusional needs and to improved general conditions.

Topics: Adult; Coagulation Protein Disorders; Contraceptives, Oral; Female; Follow-Up Studies; Humans; Menorrhagia; Metrorrhagia; Postpartum Hemorrhage; Pregnancy; Pregnancy Complications, Hematologic; Pregnancy Outcome; Retrospective Studies; Vitamin K

(1) Erroneous administration to an infant of methylergometrine intended to treat postpartum haemorrhage in the mother can have severe repercussions for the child. (2) The risk is particularly high when the mother and newborn are being treated simultaneously immediately after delivery or in the postpartum period.

Topics: Administration, Intranasal; Administration, Oral; Child; Female; Humans; Infant, Newborn; Injections, Intramuscular; Medication Errors; Methylergonovine; Mothers; Oxytocics; Postpartum Hemorrhage; Pregnancy; Vitamin K

Oxytocin has been used for several decades in close proximity to newborns, yet no published information is available regarding complications associated with its accidental administration to a newborn. We describe a case where oxytocin instead of vitamin K was accidentally administered intramuscularly to a premature infant shortly after birth. The patient described remained hemodynamically stable but developed transient hyponatremia as the sole biochemical abnormality.

Topics: Apnea; Bradycardia; Female; Humans; Hyponatremia; Infant, Newborn; Infant, Premature; Injections, Intramuscular; Medication Errors; Oxytocin; Postpartum Hemorrhage; Vitamin K; Vitamin K Deficiency

Topics: Abortion, Spontaneous; Adult; Aminobenzoates; Echinococcosis; Factor V Deficiency; Female; Humans; Hypoprothrombinemias; Obstetric Labor Complications; Postpartum Hemorrhage; Pregnancy; Pregnancy Complications; Uterine Hemorrhage; Vitamin K