Compounds > vitamin-k-semiquinone-radical

vitamin-k-semiquinone-radical and Mitochondrial-Myopathies

vitamin-k-semiquinone-radical has been researched along with Mitochondrial-Myopathies* in 2 studies

Trials

1 trial(s) available for vitamin-k-semiquinone-radical and Mitochondrial-Myopathies

ArticleYear
The treatment of mitochondrial myopathies and encephalomyopathies.
    Biochimica et biophysica acta, 1995, May-24, Volume: 1271, Issue:1

    This paper briefly summarizes the results of a long-term, open pharmacotherapy trial in 16 patients with well-characterized mitochondrial disease. Outcome measures included repeated clinical evaluation, 31P-NMR spectroscopy and near-infrared spectroscopy. Treated patients appeared to survive longer with less functional disability and medical complications than typically seen in clinical practice.

    Topics: Adolescent; Adult; Age of Onset; Antioxidants; Ascorbic Acid; Child; Coenzymes; Female; Humans; Kearns-Sayre Syndrome; Male; MELAS Syndrome; MERRF Syndrome; Methylprednisolone; Middle Aged; Mitochondrial Myopathies; Oxidative Phosphorylation; Oxygen Consumption; Treatment Outcome; Ubiquinone; Vitamin E; Vitamin K; Vitamins

1995

Other Studies

1 other study(ies) available for vitamin-k-semiquinone-radical and Mitochondrial-Myopathies

ArticleYear
Treatment of experimental NADH ubiquinone reductase deficiency with menadione.
    Brain : a journal of neurology, 1992, Volume: 115 ( Pt 4)

    Chronic administration of diphenylene iodonium (DPI) to rats has been shown to model the characteristics of mitochondrial myopathy. Using this model the efficacy of menadione therapy has been assessed. Menadione treatment of rats injected with DPI was associated with improved weight gain and increased survival rate. This was accompanied by an improvement in muscle function as judged by analysis of isometric twitch tension of the gastrocnemius muscle (1 Hz for 20 min). The decline in phosphocreatine (PCr) levels in the gastrocnemius muscle during stimulation and delayed recovery in PCr after stimulation were similar in the menadione treated and untreated models. Menadione treatment of the DPI model resulted in a resting intramuscular pH significantly lower than control or untreated DPI rats, but a similar decline in intramuscular pH to the DPI rats during stimulation. The changes in metabolite levels were broadly similar in both the menadione treated and untreated DPI models following stimulation, although the changes, except for increased lactate concentration, were generally less marked in the menadione-treated DPI model.

    Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Biphenyl Compounds; Drug Therapy, Combination; Electron Transport; Electron Transport Complex I; Hindlimb; Magnetic Resonance Spectroscopy; Male; Mitochondrial Myopathies; Muscles; NADH, NADPH Oxidoreductases; Onium Compounds; Phosphates; Phosphocreatine; Rats; Rats, Wistar; Vitamin K

1992