Compounds > vitamin-k-semiquinone-radical

vitamin-k-semiquinone-radical and Lymphoma--T-Cell

vitamin-k-semiquinone-radical has been researched along with Lymphoma--T-Cell* in 1 studies

Other Studies

1 other study(ies) available for vitamin-k-semiquinone-radical and Lymphoma--T-Cell

ArticleYear
Molecular mechanisms of the antiproliferative effect of vitamin K3 on Jurkat cells.
    Biochemistry. Biokhimiia, 1999, Volume: 64, Issue:4

    Molecular mechanisms of the antiproliferative effect of vitamin K3 (sodium 2,3-dihydro-2-methyl-1,4-naphthoquinone-2-sulfonate) were studied on a human T-lymphoma model (Jurkat cell line). It is shown that a short-term treatment of the cells with vitamin K3 damages their genomic DNA. Further culturing of the cells in the presence of vitamin K3 decreases the expression of the c-myc gene, inhibits the activity of DNA-dependent DNA-polymerases, and leads to the subsequent development of apoptosis. Combined exposure to vitamin K3 and azidothymidine has a synergistic antiproliferative effect.

    Topics: Cell Division; DNA Fragmentation; Drug Synergism; Gene Expression Regulation, Neoplastic; Genes, myc; Humans; Jurkat Cells; Lymphoma, T-Cell; Vitamin K; Zidovudine

1999