vitamin-k-semiquinone-radical and Intestinal-Obstruction

Fetal brain hemorrhage is rare. It is caused mainly by maternal trauma or fetal coagulation disorder, but in some cases, vitamin K deficiency may be the cause.. We describe the case of a pregnant woman with bowel obstruction who was susceptible to vitamin K deficiency due to oral diet restriction, decreased intestinal absorption, and limited intravenous vitamin K supplementation.. After 18 days of intermittent total parenteral nutrition, acute onset of severe fetal brain hemorrhage developed.. After acute onset of fetal brain hemorrhage, the patient underwent an emergency cesarean section at 25 + 3 weeks of gestation due to fetal non-reassuring fetal monitoring.. The Apgar score at birth was 0/0, and despite cardiopulmonary resuscitation, neonatal death was confirmed. After the baby was delivered, we checked the maternal upper abdominal cavity and found a massive adhesion in the small bowel to the abdominal wall near the liver and stomach with an adhesion band. The adhesion band, presumably a complication of previous hepatobiliary surgery, appeared to have caused small bowel obstruction. Adhesiolysis between the small bowel and abdominal wall was performed.. This case demonstrates that even relatively short-term total parenteral nutrition can cause severe fetal brain hemorrhage. Vitamin K supplementation is required for mothers who are expected to be vitamin K deficient, especially if they are on total parenteral nutrition for more than 3 weeks.

Topics: Adult; Cesarean Section; Female; Fetal Diseases; Humans; Infant, Newborn; Intestinal Obstruction; Intracranial Hemorrhages; Parenteral Nutrition, Total; Pregnancy; Vitamin K; Vitamin K Deficiency

Topics: Gastrointestinal Hemorrhage; Humans; Intestinal Obstruction; Male; Middle Aged; Tomography, X-Ray Computed; Treatment Outcome; Vitamin K

Topics: 4-Hydroxycoumarins; Adult; Anticoagulants; Biopsy; Blood Coagulation; Blood Component Transfusion; Duodenal Diseases; Hematoma; Humans; Intestinal Obstruction; Jejunal Diseases; Male; Risk Factors; Rodenticides; Tomography, X-Ray Computed; Treatment Outcome; Vitamin K

The correlation between the dose of menatetrenone and the incidence of post-laparotomy peritoneal adhesion in Ryan's model was investigated with the use of rats. In the menatetrenone treated group, the menatetrenone was intramuscularly given in a dosage of 10 mg immediately after closure of the abdominal wound and every 24 hours for two days. In this group, the incidence of ceco-colonic adhesion was 54% (20/37), whereas the incidence in non-treated group was 26% (10/39) (p less than 0.012). Especially in cases with an air-drying time of 1-2 minutes, the difference between incidences of ceco-colonic adhesion in the menatetrenone and that of the non-treated group was high. The former incidence was 61% (17/28) and that of the latter was 21% (6/29) (p less than 0.01). In addition, the incidence of peritoneal adhesion was proportionally dose-dependent to the menatetrenone. In our clinical retrospective study, the incidence of post-gastrectomy adhesive ileus increased with menatetrenone treatment to a significant degree. It is concluded that prophylactic administration of a large dose of menatetrenone should be avoided, because the incidence of post-laparotomy peritoneal adhesion could be increased.

Topics: Animals; Hemostatics; Intestinal Diseases; Intestinal Obstruction; Male; Peritoneal Diseases; Postoperative Complications; Rats; Rats, Inbred Strains; Tissue Adhesions; Vitamin K; Vitamin K 2

Topics: Aged; Colonic Diseases; Coumarins; Gastrointestinal Hemorrhage; Hematoma; Humans; Intestinal Obstruction; Intestine, Small; Male; Middle Aged; Radiography; Vitamin K

Topics: Amino Acids; Body Weight; Bronchial Fistula; Enteral Nutrition; Esophageal Atresia; Female; Gastrostomy; Humans; Infant Food; Infant, Newborn; Infant, Newborn, Diseases; Intestinal Obstruction; Lipids; Liver Function Tests; Male; Osmolar Concentration; Postoperative Care; Radiography; Sucrose; Tracheoesophageal Fistula; Vitamin K

Topics: Adult; Aged; Anti-Bacterial Agents; Anticoagulants; Female; Gastrointestinal Hemorrhage; Hematoma; Humans; Intestinal Diseases; Intestinal Obstruction; Intestine, Small; Male; Middle Aged; Radiography; Vitamin K

Topics: Diet Therapy; Ethyl Biscoumacetate; Hematoma; Hemoperitoneum; Humans; Intestinal Obstruction; Jejunum; Male; Middle Aged; Prothrombin; Thrombosis; Vitamin K

Topics: Aged; Electrocardiography; Hemoperitoneum; Humans; Intestinal Obstruction; Male; Mesenteric Vascular Occlusion; Middle Aged; Myocardial Infarction; Vitamin K; Warfarin

Topics: Barium Sulfate; Celiac Disease; Colonic Diseases; Congenital Abnormalities; Constriction, Pathologic; Dietary Fats; Ecchymosis; Glucose Tolerance Test; Humans; Infant; Intestinal Obstruction; Jejunum; Malabsorption Syndromes; Pathology; Rotation; Surgical Procedures, Operative; Vitamin A; Vitamin K; Xylose

Topics: Congenital Abnormalities; Diarrhea; Dietary Fats; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Intestinal Absorption; Intestinal Obstruction; Intestine, Small; Intestines; Iron; Prothrombin; Surgical Procedures, Operative; Vitamin B 12; Vitamin K

Topics: Anticoagulants; Antifibrinolytic Agents; Hematoma; Heparin Antagonists; Humans; Intestinal Obstruction; Vitamin K

Topics: Humans; Intestinal Obstruction; Vitamin A; Vitamin K; Vitamins