vitamin-k-semiquinone-radical has been researched along with Insulinoma* in 1 studies
1 other study(ies) available for vitamin-k-semiquinone-radical and Insulinoma
Article | Year |
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Synthesis of gamma-carboxylated polypeptides by alpha-cells of the pancreatic islets.
gamma-Carboxylated proteins were detected in normal human pancreas by immunohistochemistry with a monoclonal antibody (M3B) specific for gamma-carboxyglutamyl residues. Staining appeared to be localized to the glucagon-secreting alpha-cells in the islets of Langerhans. Consistent with this, sections from a glucagonoma were stained much more intensely with the M3B antibody than those from an insulinoma. A murine alpha-cell line (alphaTC1 Clone 9) was cultured and gamma-carboxylated polypeptides, identified immunologically as prothrombin, protein S and (tentatively) Gas6, were isolated from the intracellular compartment by chromatography on an M3B-coupled resin. As in liver, prothrombin is synthesized by alpha-cells as a gamma-carboxylated zymogen that can be cleaved by ecarin to form an active serine protease that is inhibited by hirudin. The pancreas thus appears to be a novel site of synthesis for certain vitamin K-dependent proteins. Topics: 1-Carboxyglutamic Acid; Animals; Antibodies, Monoclonal; Clone Cells; Glucagonoma; Humans; Immunohistochemistry; Insulinoma; Islets of Langerhans; Mice; Pancreatic Neoplasms; Protein Biosynthesis; Protein S; Proteins; Prothrombin; Vitamin K | 2001 |