vitamin-k-semiquinone-radical and Infertility--Male

vitamin-k-semiquinone-radical has been researched along with Infertility--Male* in 2 studies

Other Studies

2 other study(ies) available for vitamin-k-semiquinone-radical and Infertility--Male

ArticleYear
Vitamin K-Dependent γ-Glutamyl Carboxylase in Sertoli Cells Is Essential for Male Fertility in Mice.
    Molecular and cellular biology, 2021, 03-24, Volume: 41, Issue:4

    γ-Glutamyl carboxylase (GGCX) is a vitamin K (VK)-dependent enzyme that catalyzes the γ-carboxylation of glutamic acid residues in VK-dependent proteins. The anticoagulant warfarin is known to reduce GGCX activity by inhibiting the VK cycle and was recently shown to disrupt spermatogenesis. To explore GGCX function in the testis, here, we generated Sertoli cell-specific

    Topics: Animals; Carbon-Carbon Ligases; Connexin 43; Germ Cells; Infertility, Male; Male; Mice; Sertoli Cells; Spermatogenesis; Vitamin K

2021
Warfarin-induced vitamin K deficiency affects spermatogenesis in Sprague-Dawley rats.
    Andrologia, 2019, Volume: 51, Issue:10

    Vitamin K is present in the testes though its actual function in male reproduction is poorly understood. This study investigated the harmful effect of extrahepatic vitamin K insufficiency on the testicular structure. Sprague-Dawley rats were fed with a diet containing warfarin for 2, 4 and 8 weeks; control animals received a standard diet without warfarin. It was found that extrahepatic vitamin K deficiency that is induced by warfarin results in histopathological features that range from delayed spermiation, presence of multinucleated giant cells in the seminiferous tubules, germ cells degeneration, asthenozoospermia, oligozoospermia and increase in the percentage of abnormal sperm morphology when compared to the controls. Data obtained from the two groups were analysed using the Student t test. It is concluded that warfarin-induced vitamin K deficiency has a negative impact on spermatogenesis.

    Topics: Administration, Oral; Animals; Disease Models, Animal; Humans; Infertility, Male; Male; Rats; Rats, Sprague-Dawley; Seminiferous Tubules; Spermatogenesis; Spermatozoa; Vitamin K; Vitamin K Deficiency; Warfarin

2019
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